Summary of biological research on hepatoblastoma: a scoping review
BackgroundHepatoblastoma is the most prevalent primary hepatic malignancy in children, comprising 80% of pediatric hepatic malignancies and 1% of all pediatric malignancies. However, traditional treatments have proven inadequate in effectively curing hepatoblastoma, leading to a poor prognosis.Metho...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-02-01
|
| Series: | Frontiers in Pediatrics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2024.1309693/full |
| _version_ | 1797321052585459712 |
|---|---|
| author | Huan-sheng Wang Jing Lao Ren-sen Jiang Bin Wang Xiao-peng Ma Jian-yao Wang |
| author_facet | Huan-sheng Wang Jing Lao Ren-sen Jiang Bin Wang Xiao-peng Ma Jian-yao Wang |
| author_sort | Huan-sheng Wang |
| collection | DOAJ |
| description | BackgroundHepatoblastoma is the most prevalent primary hepatic malignancy in children, comprising 80% of pediatric hepatic malignancies and 1% of all pediatric malignancies. However, traditional treatments have proven inadequate in effectively curing hepatoblastoma, leading to a poor prognosis.MethodsA literature search was conducted on multiple electronic databases (PubMed and Google Scholar). A total of 86 articles were eligible for inclusion in this review.ResultThis review aims to consolidate recent developments in hepatoblastoma research, focusing on the latest advances in cancer-associated genomics, epigenetic studies, transcriptional programs and molecular subtypes. We also discuss the current treatment approaches and forthcoming strategies to address cancer-associated biological challenges.ConclusionTo provide a comprehensive summary of the molecular mechanisms associated with hepatoblastoma occurrence, this review highlights three key aspects: genomics, epigenetics, and transcriptomics. Our review aims to facilitate the exploration of novel molecular mechanisms and the development of innovative clinical treatment strategies for hepatoblastoma. |
| first_indexed | 2024-03-08T04:51:57Z |
| format | Article |
| id | doaj.art-bd047a8133fd464c9dbed98d11069767 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-03-08T04:51:57Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-bd047a8133fd464c9dbed98d110697672024-02-08T04:59:15ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602024-02-011210.3389/fped.2024.13096931309693Summary of biological research on hepatoblastoma: a scoping reviewHuan-sheng Wang0Jing Lao1Ren-sen Jiang2Bin Wang3Xiao-peng Ma4Jian-yao Wang5Department of General Surgery, Shenzhen Children’s Hospital of China Medical University, Shenzhen, Guangdong Province, ChinaDepartment of General Surgery, Shenzhen Children’s Hospital of China Medical University, Shenzhen, Guangdong Province, ChinaDepartment of General Surgery, Shenzhen Children’s Hospital of ShanTou University, Shenzhen, Guangdong Province, ChinaDepartment of General Surgery, Shenzhen Children’s Hospital, Shenzhen, Guangdong Province, ChinaDepartment of General Surgery, Shenzhen Children’s Hospital, Shenzhen, Guangdong Province, ChinaDepartment of General Surgery, Shenzhen Children’s Hospital, Shenzhen, Guangdong Province, ChinaBackgroundHepatoblastoma is the most prevalent primary hepatic malignancy in children, comprising 80% of pediatric hepatic malignancies and 1% of all pediatric malignancies. However, traditional treatments have proven inadequate in effectively curing hepatoblastoma, leading to a poor prognosis.MethodsA literature search was conducted on multiple electronic databases (PubMed and Google Scholar). A total of 86 articles were eligible for inclusion in this review.ResultThis review aims to consolidate recent developments in hepatoblastoma research, focusing on the latest advances in cancer-associated genomics, epigenetic studies, transcriptional programs and molecular subtypes. We also discuss the current treatment approaches and forthcoming strategies to address cancer-associated biological challenges.ConclusionTo provide a comprehensive summary of the molecular mechanisms associated with hepatoblastoma occurrence, this review highlights three key aspects: genomics, epigenetics, and transcriptomics. Our review aims to facilitate the exploration of novel molecular mechanisms and the development of innovative clinical treatment strategies for hepatoblastoma.https://www.frontiersin.org/articles/10.3389/fped.2024.1309693/fullhepatoblastoma (HB)genomicsβ-catenintranscriptomicsepigenetic |
| spellingShingle | Huan-sheng Wang Jing Lao Ren-sen Jiang Bin Wang Xiao-peng Ma Jian-yao Wang Summary of biological research on hepatoblastoma: a scoping review Frontiers in Pediatrics hepatoblastoma (HB) genomics β-catenin transcriptomics epigenetic |
| title | Summary of biological research on hepatoblastoma: a scoping review |
| title_full | Summary of biological research on hepatoblastoma: a scoping review |
| title_fullStr | Summary of biological research on hepatoblastoma: a scoping review |
| title_full_unstemmed | Summary of biological research on hepatoblastoma: a scoping review |
| title_short | Summary of biological research on hepatoblastoma: a scoping review |
| title_sort | summary of biological research on hepatoblastoma a scoping review |
| topic | hepatoblastoma (HB) genomics β-catenin transcriptomics epigenetic |
| url | https://www.frontiersin.org/articles/10.3389/fped.2024.1309693/full |
| work_keys_str_mv | AT huanshengwang summaryofbiologicalresearchonhepatoblastomaascopingreview AT jinglao summaryofbiologicalresearchonhepatoblastomaascopingreview AT rensenjiang summaryofbiologicalresearchonhepatoblastomaascopingreview AT binwang summaryofbiologicalresearchonhepatoblastomaascopingreview AT xiaopengma summaryofbiologicalresearchonhepatoblastomaascopingreview AT jianyaowang summaryofbiologicalresearchonhepatoblastomaascopingreview |