Inhibition of SAT1 alleviates chondrocyte inflammation and ferroptosis by repressing ALOX15 expression and activating the Nrf2 pathway

Inhibition of SAT1 alleviates chondrocyte inflammation and ferroptosis by repressing ALOX15 expression and activating the Nrf2 pathway

Aims: Osteoarthritis (OA) is the most common chronic pathema of human joints. The pathogenesis is complex, involving physiological and mechanical factors. In previous studies, we found that ferroptosis is intimately related to OA, while the role of Sat1 in chondrocyte ferroptosis and OA, as well as...

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Bibliographic Details
Main Authors: Jingting Xu, Zhaoxuan Ruan, Zhou Guo, Liangcai Hou, Genchun Wang, Zehang Zheng, Xiong Zhang, Haigang Liu, Kai Sun, Fengjing Guo
Format: Article
Language:English
Published: The British Editorial Society of Bone & Joint Surgery 2024-03-01
Series:Bone & Joint Research
Subjects:
osteoarthritis
chondrocyte
ferroptosis
inflammation
chondrocytes
collagen ii
intra-articular injection
lipid
collagen
interleukin-1β
rna
reactive oxygen species
destabilization of the medial meniscus (dmm) surgery
Online Access:https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.133.BJR-2023-0250.R1

Internet

https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.133.BJR-2023-0250.R1

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