Flaxseed oil alleviates dextran sulphate sodium-induced ulcerative colitis in rats
Flaxseed oil is a type of herbal oil obtained from the ripened seeds of the flax plant (Linum usitatissimum L.) that is widely utilized for baked foods. The aim of present study was to investigate the effect of flaxseed oil on ulcerative colitis. The rats were gavaged daily with flaxseed oil at dose...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-01-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464619305262 |
| _version_ | 1818723491196698624 |
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| author | Qian Zhou Lei Ma Wenyang Zhao Wen Zhao Xue Han Jiahui Niu Rongbin Li Changhui Zhao |
| author_facet | Qian Zhou Lei Ma Wenyang Zhao Wen Zhao Xue Han Jiahui Niu Rongbin Li Changhui Zhao |
| author_sort | Qian Zhou |
| collection | DOAJ |
| description | Flaxseed oil is a type of herbal oil obtained from the ripened seeds of the flax plant (Linum usitatissimum L.) that is widely utilized for baked foods. The aim of present study was to investigate the effect of flaxseed oil on ulcerative colitis. The rats were gavaged daily with flaxseed oil at doses of 400, 800 and 1600 mg/kg b.w. for six weeks, while ulcerative colitis was induced by daily administrating with 3% (w/v) dextran sulfate sodium (DSS) on the sixth week. Results showed that the rats fed with flaxseed oil had less disease activity index, colon weight, colon weight/length ratio and colon cell damage. Flaxseed oil consumption relieved the oxidative condition, reduced colon inflammation and partly restored the microbiota change by DSS. Flaxseed oil (1600 mg/kg b.w.) has a great potential in prevention of ulcerative colitis possibly by regulating the oxidative condition, inflammatory factors and cecal microbiota. |
| first_indexed | 2024-12-17T21:11:22Z |
| format | Article |
| id | doaj.art-bd077929927149a183c5608bcea6fbaa |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-17T21:11:22Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-bd077929927149a183c5608bcea6fbaa2022-12-21T21:32:28ZengElsevierJournal of Functional Foods1756-46462020-01-0164103602Flaxseed oil alleviates dextran sulphate sodium-induced ulcerative colitis in ratsQian Zhou0Lei Ma1Wenyang Zhao2Wen Zhao3Xue Han4Jiahui Niu5Rongbin Li6Changhui Zhao7College of Food Science and Technology, Hebei Agricultural University, Baoding 071000, PR China; Engineering Technology Research Center for Agricultural Product Processing of Hebei, Baoding 071000, PR ChinaCollege of Food Science and Technology, Hebei Agricultural University, Baoding 071000, PR ChinaCollege of Food Science and Technology, Hebei Agricultural University, Baoding 071000, PR ChinaCollege of Food Science and Technology, Hebei Agricultural University, Baoding 071000, PR China; Engineering Technology Research Center for Agricultural Product Processing of Hebei, Baoding 071000, PR China; Corresponding author at: College of Food Science and Technology, Hebei Agricultural University, Baoding 071000, PR China.College of Food Science and Technology, Hebei Agricultural University, Baoding 071000, PR ChinaCollege of Food Science and Technology, Hebei Agricultural University, Baoding 071000, PR ChinaCollege of Food Science and Technology, Hebei Agricultural University, Baoding 071000, PR ChinaCollege of Food Science and Engineering, Jilin University, Changchun 130062, PR ChinaFlaxseed oil is a type of herbal oil obtained from the ripened seeds of the flax plant (Linum usitatissimum L.) that is widely utilized for baked foods. The aim of present study was to investigate the effect of flaxseed oil on ulcerative colitis. The rats were gavaged daily with flaxseed oil at doses of 400, 800 and 1600 mg/kg b.w. for six weeks, while ulcerative colitis was induced by daily administrating with 3% (w/v) dextran sulfate sodium (DSS) on the sixth week. Results showed that the rats fed with flaxseed oil had less disease activity index, colon weight, colon weight/length ratio and colon cell damage. Flaxseed oil consumption relieved the oxidative condition, reduced colon inflammation and partly restored the microbiota change by DSS. Flaxseed oil (1600 mg/kg b.w.) has a great potential in prevention of ulcerative colitis possibly by regulating the oxidative condition, inflammatory factors and cecal microbiota.http://www.sciencedirect.com/science/article/pii/S1756464619305262Flaxseed oilDextran sulfate sodium (DSS)Ulcerative colitisInflammatory cytokineGut microbiota |
| spellingShingle | Qian Zhou Lei Ma Wenyang Zhao Wen Zhao Xue Han Jiahui Niu Rongbin Li Changhui Zhao Flaxseed oil alleviates dextran sulphate sodium-induced ulcerative colitis in rats Journal of Functional Foods Flaxseed oil Dextran sulfate sodium (DSS) Ulcerative colitis Inflammatory cytokine Gut microbiota |
| title | Flaxseed oil alleviates dextran sulphate sodium-induced ulcerative colitis in rats |
| title_full | Flaxseed oil alleviates dextran sulphate sodium-induced ulcerative colitis in rats |
| title_fullStr | Flaxseed oil alleviates dextran sulphate sodium-induced ulcerative colitis in rats |
| title_full_unstemmed | Flaxseed oil alleviates dextran sulphate sodium-induced ulcerative colitis in rats |
| title_short | Flaxseed oil alleviates dextran sulphate sodium-induced ulcerative colitis in rats |
| title_sort | flaxseed oil alleviates dextran sulphate sodium induced ulcerative colitis in rats |
| topic | Flaxseed oil Dextran sulfate sodium (DSS) Ulcerative colitis Inflammatory cytokine Gut microbiota |
| url | http://www.sciencedirect.com/science/article/pii/S1756464619305262 |
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