Evaluation and characterization of 125 patients with a history of reaction to beta-lactams
Background: Reactions to beta-lactams are frequent and it is difficult to establish the relationship between the drug and symptoms. Objective: To describe the clinical characteristics and explore the immunological mechanisms of patients with suspected adverse reaction to beta-lactams. Methods: Ret...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Colegio Mexicano de Inmunología Clínica y Alergia, A.C.
2016-08-01
|
| Series: | Revista Alergia México |
| Subjects: | |
| Online Access: | http://revistaalergia.mx/ojs/index.php/ram/article/view/115 |
| _version_ | 1827842281396240384 |
|---|---|
| author | Kaddy Juliana Beltrán-Sierra Jorge Sánchez Ricardo Cardona |
| author_facet | Kaddy Juliana Beltrán-Sierra Jorge Sánchez Ricardo Cardona |
| author_sort | Kaddy Juliana Beltrán-Sierra |
| collection | DOAJ |
| description | Background: Reactions to beta-lactams are frequent and it is difficult to establish the relationship between the drug and symptoms.
Objective: To describe the clinical characteristics and explore the immunological mechanisms of patients with suspected adverse reaction to beta-lactams.
Methods: Retrospective study of patients with a history of beta-lactam reaction and tests for reactions to drugs.
Results: Out of 125 patients, 71 were women (56.8%); 73 had a history of immediate reaction and 52 delayed reaction; 590 allergy tests were done: specific IgE measurement, skin prick, patch, and provocation tests. The drugs most often related were amoxycillin, in 62 patients (49.6%), crystalline penicillin in 17 (13.6%), benzathine penicillin in 15 (12%), and cefalexin in 13 (10.4%). The severity of the reaction was mild in the majority (82%). 7.7% had a history of anaphylaxis and 10.8% sought care for a positive penicillin skin test, without history of reaction. Only 6.7% resulted in a positive test. More than 62% began testing two years after the reaction for which they sought care.
Conclusions: The clinical history is insufficient to determine allergy to beta-lactams. In our sample, few patients with a history of beta-lactam reaction had evidence of immune-mediated reactions. |
| first_indexed | 2024-03-12T08:07:11Z |
| format | Article |
| id | doaj.art-bd077f9020f2495a8c6d2938a46a64cd |
| institution | Directory Open Access Journal |
| issn | 0002-5151 2448-9190 |
| language | English |
| last_indexed | 2024-03-12T08:07:11Z |
| publishDate | 2016-08-01 |
| publisher | Colegio Mexicano de Inmunología Clínica y Alergia, A.C. |
| record_format | Article |
| series | Revista Alergia México |
| spelling | doaj.art-bd077f9020f2495a8c6d2938a46a64cd2023-09-02T19:26:46ZengColegio Mexicano de Inmunología Clínica y Alergia, A.C.Revista Alergia México0002-51512448-91902016-08-0163322723610.29262/ram.v63i3.115133Evaluation and characterization of 125 patients with a history of reaction to beta-lactamsKaddy Juliana Beltrán-Sierra0Jorge Sánchez1Ricardo Cardona2Universidad de Antioquia, Grupo de Alergología Clínica y Experimental, MedellínUniversidad de Antioquia, Grupo de Alergología Clínica y Experimental, MedellínUniversidad de Antioquia, Grupo de Alergología Clínica y Experimental, MedellínBackground: Reactions to beta-lactams are frequent and it is difficult to establish the relationship between the drug and symptoms. Objective: To describe the clinical characteristics and explore the immunological mechanisms of patients with suspected adverse reaction to beta-lactams. Methods: Retrospective study of patients with a history of beta-lactam reaction and tests for reactions to drugs. Results: Out of 125 patients, 71 were women (56.8%); 73 had a history of immediate reaction and 52 delayed reaction; 590 allergy tests were done: specific IgE measurement, skin prick, patch, and provocation tests. The drugs most often related were amoxycillin, in 62 patients (49.6%), crystalline penicillin in 17 (13.6%), benzathine penicillin in 15 (12%), and cefalexin in 13 (10.4%). The severity of the reaction was mild in the majority (82%). 7.7% had a history of anaphylaxis and 10.8% sought care for a positive penicillin skin test, without history of reaction. Only 6.7% resulted in a positive test. More than 62% began testing two years after the reaction for which they sought care. Conclusions: The clinical history is insufficient to determine allergy to beta-lactams. In our sample, few patients with a history of beta-lactam reaction had evidence of immune-mediated reactions.http://revistaalergia.mx/ojs/index.php/ram/article/view/115AlergiaBetalactámicosAnafilaxiaAngioedema |
| spellingShingle | Kaddy Juliana Beltrán-Sierra Jorge Sánchez Ricardo Cardona Evaluation and characterization of 125 patients with a history of reaction to beta-lactams Revista Alergia México Alergia Betalactámicos Anafilaxia Angioedema |
| title | Evaluation and characterization of 125 patients with a history of reaction to beta-lactams |
| title_full | Evaluation and characterization of 125 patients with a history of reaction to beta-lactams |
| title_fullStr | Evaluation and characterization of 125 patients with a history of reaction to beta-lactams |
| title_full_unstemmed | Evaluation and characterization of 125 patients with a history of reaction to beta-lactams |
| title_short | Evaluation and characterization of 125 patients with a history of reaction to beta-lactams |
| title_sort | evaluation and characterization of 125 patients with a history of reaction to beta lactams |
| topic | Alergia Betalactámicos Anafilaxia Angioedema |
| url | http://revistaalergia.mx/ojs/index.php/ram/article/view/115 |
| work_keys_str_mv | AT kaddyjulianabeltransierra evaluationandcharacterizationof125patientswithahistoryofreactiontobetalactams AT jorgesanchez evaluationandcharacterizationof125patientswithahistoryofreactiontobetalactams AT ricardocardona evaluationandcharacterizationof125patientswithahistoryofreactiontobetalactams |