The prognostic value of preoperative serum CA724 for CEA-normal colorectal cancer patients
Background and Purpose There had been no recognized serum tumor marker to predict the prognosis of colorectal cancer (CRC) patients with normal preoperative serum carcinoembryonic antigen (CEA) levels. The purpose of this study was to determine whether preoperative serum carbohydrate antigen 724 (CA...
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PeerJ Inc.
2020-04-01
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| author | Jiaan Kuang Yizhen Gong Hailun Xie Ling Yan Shizhen Huang Feng Gao Shuangyi Tang Jialiang Gan |
| author_facet | Jiaan Kuang Yizhen Gong Hailun Xie Ling Yan Shizhen Huang Feng Gao Shuangyi Tang Jialiang Gan |
| author_sort | Jiaan Kuang |
| collection | DOAJ |
| description | Background and Purpose There had been no recognized serum tumor marker to predict the prognosis of colorectal cancer (CRC) patients with normal preoperative serum carcinoembryonic antigen (CEA) levels. The purpose of this study was to determine whether preoperative serum carbohydrate antigen 724 (CA724) was of predictive function for the prognosis of CRC patients with normal CEA levels. Methods The medical records of 295 CRC patients with normal CEA levels who underwent surgery at the Department of Colorectal Anal Surgery of the First Affiliated Hospital of Guangxi Medical University (Guangxi, China) between September 2012 and September 2014 were retrospectively reviewed. The Chi-square test was used to test the correlation between preoperative serum CA724 levels and clinical features. Kaplan–Meier curves were conducted to calculate the overall survival (OS) rate and disease-free survival (DFS) of patients. Cox regression analysis was applied to conduct univariate and multivariate analysis of the following four preoperative serum tumor makers namely CA724, carbohydrate antigen 199 (CA199), carcinoembryonic antigen 125 (CA125), carcinoembryonic antigen 242 (CA242) and clinical features. Nomograms for prognostic parameter of OS and DFS were developed using R v3.2.5. Results In the Chi-square test, only pathological node stage (pN stage) (X2 = 14.514, P = 0.001) and differentiation (X2 = 10.712, P = 0.001) were associated with serum CA724 levels. In the Kaplan–Meier analysis, the results revealed that the OS and DFS in patients with high CA724 was poorer than those with normal. In the multivariate Cox regression analysis of OS and DFS, only pT stage, pN stage, metastasis and serum CA724 were independent prognostic risk factors for CRC patients with normal CEA levels. Conclusion Preoperative serum CA724 might serve as a potential prognostic factor for CRC patients with normal serum CEA levels. |
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| spelling | doaj.art-bd08d7fa70d5419f8413b7fbf7cc065b2023-12-03T11:21:13ZengPeerJ Inc.PeerJ2167-83592020-04-018e893610.7717/peerj.8936The prognostic value of preoperative serum CA724 for CEA-normal colorectal cancer patientsJiaan Kuang0Yizhen Gong1Hailun Xie2Ling Yan3Shizhen Huang4Feng Gao5Shuangyi Tang6Jialiang Gan7Department of Colorectal Anal Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, ChinaDepartment of Colorectal Anal Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, ChinaDepartment of Colorectal Anal Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, ChinaDepartment of Colorectal Anal Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, ChinaDepartment of Colorectal Anal Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, ChinaDepartment of Colorectal Anal Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, ChinaDepartment of Pharmacy, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, ChinaDepartment of Colorectal Anal Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, ChinaBackground and Purpose There had been no recognized serum tumor marker to predict the prognosis of colorectal cancer (CRC) patients with normal preoperative serum carcinoembryonic antigen (CEA) levels. The purpose of this study was to determine whether preoperative serum carbohydrate antigen 724 (CA724) was of predictive function for the prognosis of CRC patients with normal CEA levels. Methods The medical records of 295 CRC patients with normal CEA levels who underwent surgery at the Department of Colorectal Anal Surgery of the First Affiliated Hospital of Guangxi Medical University (Guangxi, China) between September 2012 and September 2014 were retrospectively reviewed. The Chi-square test was used to test the correlation between preoperative serum CA724 levels and clinical features. Kaplan–Meier curves were conducted to calculate the overall survival (OS) rate and disease-free survival (DFS) of patients. Cox regression analysis was applied to conduct univariate and multivariate analysis of the following four preoperative serum tumor makers namely CA724, carbohydrate antigen 199 (CA199), carcinoembryonic antigen 125 (CA125), carcinoembryonic antigen 242 (CA242) and clinical features. Nomograms for prognostic parameter of OS and DFS were developed using R v3.2.5. Results In the Chi-square test, only pathological node stage (pN stage) (X2 = 14.514, P = 0.001) and differentiation (X2 = 10.712, P = 0.001) were associated with serum CA724 levels. In the Kaplan–Meier analysis, the results revealed that the OS and DFS in patients with high CA724 was poorer than those with normal. In the multivariate Cox regression analysis of OS and DFS, only pT stage, pN stage, metastasis and serum CA724 were independent prognostic risk factors for CRC patients with normal CEA levels. Conclusion Preoperative serum CA724 might serve as a potential prognostic factor for CRC patients with normal serum CEA levels.https://peerj.com/articles/8936.pdfCA724Normal CEA levelsColorectal cancerPrognosis |
| spellingShingle | Jiaan Kuang Yizhen Gong Hailun Xie Ling Yan Shizhen Huang Feng Gao Shuangyi Tang Jialiang Gan The prognostic value of preoperative serum CA724 for CEA-normal colorectal cancer patients PeerJ CA724 Normal CEA levels Colorectal cancer Prognosis |
| title | The prognostic value of preoperative serum CA724 for CEA-normal colorectal cancer patients |
| title_full | The prognostic value of preoperative serum CA724 for CEA-normal colorectal cancer patients |
| title_fullStr | The prognostic value of preoperative serum CA724 for CEA-normal colorectal cancer patients |
| title_full_unstemmed | The prognostic value of preoperative serum CA724 for CEA-normal colorectal cancer patients |
| title_short | The prognostic value of preoperative serum CA724 for CEA-normal colorectal cancer patients |
| title_sort | prognostic value of preoperative serum ca724 for cea normal colorectal cancer patients |
| topic | CA724 Normal CEA levels Colorectal cancer Prognosis |
| url | https://peerj.com/articles/8936.pdf |
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