Cognitive performance in bipolar disorder: Comparison between individuals with and without suicide attempts and healthy controls
Introduction: Bipolar disorder (BD) presents an elevated risk of suicide. One hypothesis for this is that cognitive impairments contribute to suicidal behavior. However, the relationship between cognition and suicidal behavior in BD remains unclear. Objective: To compare cognitive performance in ind...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | Journal of Affective Disorders Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666915324000593 |
| _version_ | 1797234288160145408 |
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| author | Mathias Hasse-Sousa Dayane Santos Martins Carolina Petry-Perin Maria Julia Silva de Britto Denise Bisolo Scheibe Joana Bücker Clarissa Severino Gama Letícia Sanguinetti Czepielewski |
| author_facet | Mathias Hasse-Sousa Dayane Santos Martins Carolina Petry-Perin Maria Julia Silva de Britto Denise Bisolo Scheibe Joana Bücker Clarissa Severino Gama Letícia Sanguinetti Czepielewski |
| author_sort | Mathias Hasse-Sousa |
| collection | DOAJ |
| description | Introduction: Bipolar disorder (BD) presents an elevated risk of suicide. One hypothesis for this is that cognitive impairments contribute to suicidal behavior. However, the relationship between cognition and suicidal behavior in BD remains unclear. Objective: To compare cognitive performance in individuals with BD with previous suicide attempts vs no attempt vs healthy controls (HC). Methods: We included 306 participants: 101 individuals with BD (49 with previous suicide attempts and 52 without attempts) and 205 HC. Participants underwent a clinical interview and neuropsychological evaluation. We assessed cognitive performance in social cognition, episodic verbal memory, working memory, processing speed, executive functioning, sustained attention, and intelligence. Afterwards, individuals with BD were separated between groups with and without suicide attempts. We then compared cognitive performance and clinical characteritics between groups. Results: Individuals with BD who attempted suicide had more hospitalizations, higher prevalence of psychiatric family history, and overall greater functional impairment. Regarding cognition, HC outperformed both BD groups, with the exception of social cognition and Stroop Color-Word and interference weighted score. However, there were no significant differences in cognitive performance among both BD groups. Limitations: Cross-sectional design and dichotomization between suicide attempt vs. no attempt Conclusions: BD with previous suicide attempt present worse clinical outcomes and higher illness severity. Nevertheless, there were no cognitive differences among individuals with BD with and without suicide attempts. Both BD groups may share a vulnerability for cognitive impairment, but not for clinical and functional outcomes. Our results point to significant heterogeneity among clinical and functioning areas of BD. |
| first_indexed | 2024-04-24T16:29:41Z |
| format | Article |
| id | doaj.art-bd0b6c19765b4cd8ae4217114778544c |
| institution | Directory Open Access Journal |
| issn | 2666-9153 |
| language | English |
| last_indexed | 2024-04-24T16:29:41Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Affective Disorders Reports |
| spelling | doaj.art-bd0b6c19765b4cd8ae4217114778544c2024-03-30T04:40:16ZengElsevierJournal of Affective Disorders Reports2666-91532024-04-0116100773Cognitive performance in bipolar disorder: Comparison between individuals with and without suicide attempts and healthy controlsMathias Hasse-Sousa0Dayane Santos Martins1Carolina Petry-Perin2Maria Julia Silva de Britto3Denise Bisolo Scheibe4Joana Bücker5Clarissa Severino Gama6Letícia Sanguinetti Czepielewski7Departamento de Psicologia do Desenvolvimento e da Personalidade, Instituto de Psicologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Programa de Pós Graduação em Psiquiatria e Ciências do Comportamento, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Corresponding author at. Rua Ramiro Barcelos, 2600, 90035003, Porto Alegre, Brazil.Departamento de Psicologia do Desenvolvimento e da Personalidade, Instituto de Psicologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, BrazilDepartamento de Psicologia do Desenvolvimento e da Personalidade, Instituto de Psicologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, BrazilDepartamento de Psicologia do Desenvolvimento e da Personalidade, Instituto de Psicologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, BrazilPrograma de Pós-Graduação em Ciências Médicas (PPGCM), Universidade do Vale do Taquari, Lajeado, BrazilPrograma de Pós-Graduação em Ciências Médicas (PPGCM), Universidade do Vale do Taquari, Lajeado, BrazilPrograma de Pós Graduação em Psiquiatria e Ciências do Comportamento, Universidade Federal do Rio Grande do Sul, Porto Alegre, BrazilDepartamento de Psicologia do Desenvolvimento e da Personalidade, Instituto de Psicologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Programa de Pós Graduação em Psiquiatria e Ciências do Comportamento, Universidade Federal do Rio Grande do Sul, Porto Alegre, BrazilIntroduction: Bipolar disorder (BD) presents an elevated risk of suicide. One hypothesis for this is that cognitive impairments contribute to suicidal behavior. However, the relationship between cognition and suicidal behavior in BD remains unclear. Objective: To compare cognitive performance in individuals with BD with previous suicide attempts vs no attempt vs healthy controls (HC). Methods: We included 306 participants: 101 individuals with BD (49 with previous suicide attempts and 52 without attempts) and 205 HC. Participants underwent a clinical interview and neuropsychological evaluation. We assessed cognitive performance in social cognition, episodic verbal memory, working memory, processing speed, executive functioning, sustained attention, and intelligence. Afterwards, individuals with BD were separated between groups with and without suicide attempts. We then compared cognitive performance and clinical characteritics between groups. Results: Individuals with BD who attempted suicide had more hospitalizations, higher prevalence of psychiatric family history, and overall greater functional impairment. Regarding cognition, HC outperformed both BD groups, with the exception of social cognition and Stroop Color-Word and interference weighted score. However, there were no significant differences in cognitive performance among both BD groups. Limitations: Cross-sectional design and dichotomization between suicide attempt vs. no attempt Conclusions: BD with previous suicide attempt present worse clinical outcomes and higher illness severity. Nevertheless, there were no cognitive differences among individuals with BD with and without suicide attempts. Both BD groups may share a vulnerability for cognitive impairment, but not for clinical and functional outcomes. Our results point to significant heterogeneity among clinical and functioning areas of BD.http://www.sciencedirect.com/science/article/pii/S2666915324000593Bipolar disorderCognitionSuicide |
| spellingShingle | Mathias Hasse-Sousa Dayane Santos Martins Carolina Petry-Perin Maria Julia Silva de Britto Denise Bisolo Scheibe Joana Bücker Clarissa Severino Gama Letícia Sanguinetti Czepielewski Cognitive performance in bipolar disorder: Comparison between individuals with and without suicide attempts and healthy controls Journal of Affective Disorders Reports Bipolar disorder Cognition Suicide |
| title | Cognitive performance in bipolar disorder: Comparison between individuals with and without suicide attempts and healthy controls |
| title_full | Cognitive performance in bipolar disorder: Comparison between individuals with and without suicide attempts and healthy controls |
| title_fullStr | Cognitive performance in bipolar disorder: Comparison between individuals with and without suicide attempts and healthy controls |
| title_full_unstemmed | Cognitive performance in bipolar disorder: Comparison between individuals with and without suicide attempts and healthy controls |
| title_short | Cognitive performance in bipolar disorder: Comparison between individuals with and without suicide attempts and healthy controls |
| title_sort | cognitive performance in bipolar disorder comparison between individuals with and without suicide attempts and healthy controls |
| topic | Bipolar disorder Cognition Suicide |
| url | http://www.sciencedirect.com/science/article/pii/S2666915324000593 |
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