Clinical improvements in temporospatial gait variables after a spinal tap test in individuals with idiopathic normal pressure hydrocephalus
Abstract Idiopathic Normal Pressure Hydrocephalus (iNPH) is a neurological condition that often presents gait disturbance in the early stages of the disease and affects other motor activities. This study investigated changes in temporospatial gait variables after cerebrospinal fluid (CSF) removal us...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-52516-3 |
| _version_ | 1797276632203919360 |
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| author | Sunee Bovonsunthonchai Theerapol Witthiwej Roongtiwa Vachalathiti Pichaya Hengsomboon Suthasinee Thong-On Sith Sathornsumetee Chanon Ngamsombat Orasa Chawalparit Weerasak Muangpaisan Jim Richards |
| author_facet | Sunee Bovonsunthonchai Theerapol Witthiwej Roongtiwa Vachalathiti Pichaya Hengsomboon Suthasinee Thong-On Sith Sathornsumetee Chanon Ngamsombat Orasa Chawalparit Weerasak Muangpaisan Jim Richards |
| author_sort | Sunee Bovonsunthonchai |
| collection | DOAJ |
| description | Abstract Idiopathic Normal Pressure Hydrocephalus (iNPH) is a neurological condition that often presents gait disturbance in the early stages of the disease and affects other motor activities. This study investigated changes in temporospatial gait variables after cerebrospinal fluid (CSF) removal using a spinal tap test in individuals with idiopathic normal pressure hydrocephalus (iNPH), and explored if the tap test responders and non-responders could be clinically identified from temporospatial gait variables. Sixty-two individuals with iNPH were recruited from an outpatient clinic, eleven were excluded, leaving a total of 51 who were included in the analysis. Temporospatial gait variables at self-selected speed were recorded at pre- and 24-h post-tap tests which were compared using Paired t-tests, Cohen’s d effect size, and percentage change. A previously defined minimal clinical important change (MCIC) for gait speed was used to determine the changes and to classify tap test responders and non-responders. A mixed model ANOVA was used to determine the within-group, between-group, and interaction effects. Comparisons of the data between pre- and post-tap tests showed significant improvements with small to medium effect sizes for left step length, right step time, stride length and time, cadence, and gait speed. Gait speed showed the largest percentage change among temporospatial gait variables. Within-group and interaction effects were found in some variables but no between-group effect was found. Tap test responders showed significant improvements in right step length and time, stride length and time, cadence, and gait speed while non-responders did not. Some individuals with iNPH showed clinically important improvements in temporospatial gait variables after the tap test, particularly in step/stride length and time, cadence, who could be classified by gait speed. However, gait-related balance variables did not change. Therefore, additional treatments should focus on improving such variables. |
| first_indexed | 2024-03-07T15:31:01Z |
| format | Article |
| id | doaj.art-bd0f3845a4a44755b147d6f4ed98c72c |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-07T15:31:01Z |
| publishDate | 2024-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-bd0f3845a4a44755b147d6f4ed98c72c2024-03-05T16:26:18ZengNature PortfolioScientific Reports2045-23222024-01-0114111010.1038/s41598-024-52516-3Clinical improvements in temporospatial gait variables after a spinal tap test in individuals with idiopathic normal pressure hydrocephalusSunee Bovonsunthonchai0Theerapol Witthiwej1Roongtiwa Vachalathiti2Pichaya Hengsomboon3Suthasinee Thong-On4Sith Sathornsumetee5Chanon Ngamsombat6Orasa Chawalparit7Weerasak Muangpaisan8Jim Richards9Faculty of Physical Therapy, Mahidol UniversityDivision of Neurosurgery, Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol UniversityFaculty of Physical Therapy, Mahidol UniversityFaculty of Physical Therapy, Mahidol UniversityFaculty of Physical Therapy, Mahidol UniversityDivision of Neurology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol UniversityDepartment of Radiology, Faculty of Medicine Siriraj Hospital, Mahidol UniversityDepartment of Radiology, Faculty of Medicine Siriraj Hospital, Mahidol UniversityDepartment of Preventive and Social Medicine, Faculty of Medicine Siriraj Hospital, Mahidol UniversityAllied Health Research Unit, University of Central LancashireAbstract Idiopathic Normal Pressure Hydrocephalus (iNPH) is a neurological condition that often presents gait disturbance in the early stages of the disease and affects other motor activities. This study investigated changes in temporospatial gait variables after cerebrospinal fluid (CSF) removal using a spinal tap test in individuals with idiopathic normal pressure hydrocephalus (iNPH), and explored if the tap test responders and non-responders could be clinically identified from temporospatial gait variables. Sixty-two individuals with iNPH were recruited from an outpatient clinic, eleven were excluded, leaving a total of 51 who were included in the analysis. Temporospatial gait variables at self-selected speed were recorded at pre- and 24-h post-tap tests which were compared using Paired t-tests, Cohen’s d effect size, and percentage change. A previously defined minimal clinical important change (MCIC) for gait speed was used to determine the changes and to classify tap test responders and non-responders. A mixed model ANOVA was used to determine the within-group, between-group, and interaction effects. Comparisons of the data between pre- and post-tap tests showed significant improvements with small to medium effect sizes for left step length, right step time, stride length and time, cadence, and gait speed. Gait speed showed the largest percentage change among temporospatial gait variables. Within-group and interaction effects were found in some variables but no between-group effect was found. Tap test responders showed significant improvements in right step length and time, stride length and time, cadence, and gait speed while non-responders did not. Some individuals with iNPH showed clinically important improvements in temporospatial gait variables after the tap test, particularly in step/stride length and time, cadence, who could be classified by gait speed. However, gait-related balance variables did not change. Therefore, additional treatments should focus on improving such variables.https://doi.org/10.1038/s41598-024-52516-3 |
| spellingShingle | Sunee Bovonsunthonchai Theerapol Witthiwej Roongtiwa Vachalathiti Pichaya Hengsomboon Suthasinee Thong-On Sith Sathornsumetee Chanon Ngamsombat Orasa Chawalparit Weerasak Muangpaisan Jim Richards Clinical improvements in temporospatial gait variables after a spinal tap test in individuals with idiopathic normal pressure hydrocephalus Scientific Reports |
| title | Clinical improvements in temporospatial gait variables after a spinal tap test in individuals with idiopathic normal pressure hydrocephalus |
| title_full | Clinical improvements in temporospatial gait variables after a spinal tap test in individuals with idiopathic normal pressure hydrocephalus |
| title_fullStr | Clinical improvements in temporospatial gait variables after a spinal tap test in individuals with idiopathic normal pressure hydrocephalus |
| title_full_unstemmed | Clinical improvements in temporospatial gait variables after a spinal tap test in individuals with idiopathic normal pressure hydrocephalus |
| title_short | Clinical improvements in temporospatial gait variables after a spinal tap test in individuals with idiopathic normal pressure hydrocephalus |
| title_sort | clinical improvements in temporospatial gait variables after a spinal tap test in individuals with idiopathic normal pressure hydrocephalus |
| url | https://doi.org/10.1038/s41598-024-52516-3 |
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