The relation between serum levels of epidermal growth factor and necrotizing enterocolitis in preterm neonates
Purpose Necrotizing enterocolitis (NEC) is one of the most serious complications of prematurity. Many risk factors can contribute to the development of NEC. The epidermal growth factor (EGF) plays a major role in intestinal barrier function, increases intestinal enzyme activity, and improves nutrien...
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| Format: | Article |
| Language: | English |
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Korean Pediatric Society
2019-08-01
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| Series: | Korean Journal of Pediatrics |
| Subjects: | |
| Online Access: | http://kjp.or.kr/upload/pdf/kjp-2018-07108.pdf |
| _version_ | 1818540424324710400 |
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| author | Heba Mostafa Ahmed Nsreen Mostafa Kamel |
| author_facet | Heba Mostafa Ahmed Nsreen Mostafa Kamel |
| author_sort | Heba Mostafa Ahmed |
| collection | DOAJ |
| description | Purpose Necrotizing enterocolitis (NEC) is one of the most serious complications of prematurity. Many risk factors can contribute to the development of NEC. The epidermal growth factor (EGF) plays a major role in intestinal barrier function, increases intestinal enzyme activity, and improves nutrient transport. The aim of this study was to assess the role of epidermal growth factor in the development of NEC in preterm neonates. Methods In this study, 130 preterm neonates were included and divided into 3 groups, as follows: group 1, 40 preterm neonates with NEC; group 2, 50 preterm neonates with sepsis; and group 3, 40 healthy preterm neonates as controls. The NEC group was then subdivided into medical and surgical NEC subgroups. The serum EGF level was measured using enzyme-linked immunosorbent assay. Results Serum EGF levels (pg/dL) were significantly lower in the NEC group (median [interquartile range, IQR], 9.6 [2–14]) than in the sepsis (10.1 [8–14]) and control groups (11.2 [8–14], P<0.001), with no significant difference between the sepsis and control groups, and were positively correlated with gestational age (r=0.7, P<0.001). A binary logistic regression test revealed that low EGF levels and gestational ages could significantly predict the development of NEC. The receiver-operating characteristic curve for EGF showed an optimal cutoff value of 8 pg/mL, with 73.3% sensitivity, 98% specificity, and an area under the curve of 0.92. Conclusion The patients with NEC in this study had significantly lower serum EGF levels (P<0.001), which indicated that EGF could be a reliable marker of NEC in preterm neonates. |
| first_indexed | 2024-12-11T21:55:10Z |
| format | Article |
| id | doaj.art-bd0fcbb678344f84acaea04a5e526203 |
| institution | Directory Open Access Journal |
| issn | 1738-1061 2092-7258 |
| language | English |
| last_indexed | 2024-12-11T21:55:10Z |
| publishDate | 2019-08-01 |
| publisher | Korean Pediatric Society |
| record_format | Article |
| series | Korean Journal of Pediatrics |
| spelling | doaj.art-bd0fcbb678344f84acaea04a5e5262032022-12-22T00:49:21ZengKorean Pediatric SocietyKorean Journal of Pediatrics1738-10612092-72582019-08-0162830731110.3345/kjp.2018.0710820125553525The relation between serum levels of epidermal growth factor and necrotizing enterocolitis in preterm neonatesHeba Mostafa Ahmed0Nsreen Mostafa Kamel1 Department of Pediatrics, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt Department of Clinical and Chemical Pathology, Faculty of Medicine, Beni-Suef University, Beni-Suef, EgyptPurpose Necrotizing enterocolitis (NEC) is one of the most serious complications of prematurity. Many risk factors can contribute to the development of NEC. The epidermal growth factor (EGF) plays a major role in intestinal barrier function, increases intestinal enzyme activity, and improves nutrient transport. The aim of this study was to assess the role of epidermal growth factor in the development of NEC in preterm neonates. Methods In this study, 130 preterm neonates were included and divided into 3 groups, as follows: group 1, 40 preterm neonates with NEC; group 2, 50 preterm neonates with sepsis; and group 3, 40 healthy preterm neonates as controls. The NEC group was then subdivided into medical and surgical NEC subgroups. The serum EGF level was measured using enzyme-linked immunosorbent assay. Results Serum EGF levels (pg/dL) were significantly lower in the NEC group (median [interquartile range, IQR], 9.6 [2–14]) than in the sepsis (10.1 [8–14]) and control groups (11.2 [8–14], P<0.001), with no significant difference between the sepsis and control groups, and were positively correlated with gestational age (r=0.7, P<0.001). A binary logistic regression test revealed that low EGF levels and gestational ages could significantly predict the development of NEC. The receiver-operating characteristic curve for EGF showed an optimal cutoff value of 8 pg/mL, with 73.3% sensitivity, 98% specificity, and an area under the curve of 0.92. Conclusion The patients with NEC in this study had significantly lower serum EGF levels (P<0.001), which indicated that EGF could be a reliable marker of NEC in preterm neonates.http://kjp.or.kr/upload/pdf/kjp-2018-07108.pdfEpidermal growth factorNeonatesNecrotizing enterocolitis |
| spellingShingle | Heba Mostafa Ahmed Nsreen Mostafa Kamel The relation between serum levels of epidermal growth factor and necrotizing enterocolitis in preterm neonates Korean Journal of Pediatrics Epidermal growth factor Neonates Necrotizing enterocolitis |
| title | The relation between serum levels of epidermal growth factor and necrotizing enterocolitis in preterm neonates |
| title_full | The relation between serum levels of epidermal growth factor and necrotizing enterocolitis in preterm neonates |
| title_fullStr | The relation between serum levels of epidermal growth factor and necrotizing enterocolitis in preterm neonates |
| title_full_unstemmed | The relation between serum levels of epidermal growth factor and necrotizing enterocolitis in preterm neonates |
| title_short | The relation between serum levels of epidermal growth factor and necrotizing enterocolitis in preterm neonates |
| title_sort | relation between serum levels of epidermal growth factor and necrotizing enterocolitis in preterm neonates |
| topic | Epidermal growth factor Neonates Necrotizing enterocolitis |
| url | http://kjp.or.kr/upload/pdf/kjp-2018-07108.pdf |
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