| Summary: | Abstract In the context of the COVID-19 pandemic, global vaccine campaigns are a mass vaccination intervention conducted through routine service provision for individuals who have reached a specified age. However, obtaining a high uptake rate to reach herd immunity may be undermined by various social motivations. To scrutinize the practical and dynamic strategies for a successful vaccination campaign, we map out the determinants that exacerbate vaccine hesitancy by leveraging the capacity of rich metadata from Twitter. Here, we uncover the collective propensities underlying dynamic social motivations and the uneven distribution of vaccines across the globe. Our findings suggest that profiling the status quo of public perceptions and engaging in introspection about vaccine-promoting policies in due course are integral components of preparedness against the ongoing pandemic. Simultaneously, we propose several recommendations to remind governments of the importance of building confidence in vaccination in a targeted way, and we assert that national barriers should be abandoned and that international responsibility should be assumed.
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