Chromatin balances cell redox and energy homeostasis
Abstract Chromatin plays a central role in the conversion of energy in cells: alteration of chromatin structure to make DNA accessible consumes energy, and compaction of chromatin preserves energy. Alteration of chromatin structure uses energy sources derived from carbon metabolism such as ATP and a...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-11-01
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| Series: | Epigenetics & Chromatin |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13072-023-00520-8 |
| _version_ | 1797413998030749696 |
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| author | Tamaki Suganuma Jerry L. Workman |
| author_facet | Tamaki Suganuma Jerry L. Workman |
| author_sort | Tamaki Suganuma |
| collection | DOAJ |
| description | Abstract Chromatin plays a central role in the conversion of energy in cells: alteration of chromatin structure to make DNA accessible consumes energy, and compaction of chromatin preserves energy. Alteration of chromatin structure uses energy sources derived from carbon metabolism such as ATP and acetyl-CoA; conversely, chromatin compaction and epigenetic modification feedback to metabolism and energy homeostasis by controlling gene expression and storing metabolites. Coordination of these dual chromatin events must be flexibly modulated in response to environmental changes such as during development and exposure to stress. Aging also alters chromatin structure and the coordination of metabolism, chromatin dynamics, and other cell processes. Noncoding RNAs and other RNA species that associate directly with chromatin or with chromatin modifiers contribute to spatiotemporal control of transcription and energy conversion. The time required for generating the large amounts of RNAs and chromatin modifiers observed in super-enhancers may be critical for regulation of transcription and may be impacted by aging. Here, taking into account these factors, we review alterations of chromatin that are fundamental to cell responses to metabolic changes due to stress and aging to maintain redox and energy homeostasis. We discuss the relationship between spatiotemporal control of energy and chromatin function, as this emerging concept must be considered to understand how cell homeostasis is maintained. |
| first_indexed | 2024-03-09T05:26:37Z |
| format | Article |
| id | doaj.art-bd107260f30f4f38a81290c7d97be8f9 |
| institution | Directory Open Access Journal |
| issn | 1756-8935 |
| language | English |
| last_indexed | 2024-03-09T05:26:37Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Epigenetics & Chromatin |
| spelling | doaj.art-bd107260f30f4f38a81290c7d97be8f92023-12-03T12:36:45ZengBMCEpigenetics & Chromatin1756-89352023-11-0116111310.1186/s13072-023-00520-8Chromatin balances cell redox and energy homeostasisTamaki Suganuma0Jerry L. Workman1Stowers Institute for Medical ResearchStowers Institute for Medical ResearchAbstract Chromatin plays a central role in the conversion of energy in cells: alteration of chromatin structure to make DNA accessible consumes energy, and compaction of chromatin preserves energy. Alteration of chromatin structure uses energy sources derived from carbon metabolism such as ATP and acetyl-CoA; conversely, chromatin compaction and epigenetic modification feedback to metabolism and energy homeostasis by controlling gene expression and storing metabolites. Coordination of these dual chromatin events must be flexibly modulated in response to environmental changes such as during development and exposure to stress. Aging also alters chromatin structure and the coordination of metabolism, chromatin dynamics, and other cell processes. Noncoding RNAs and other RNA species that associate directly with chromatin or with chromatin modifiers contribute to spatiotemporal control of transcription and energy conversion. The time required for generating the large amounts of RNAs and chromatin modifiers observed in super-enhancers may be critical for regulation of transcription and may be impacted by aging. Here, taking into account these factors, we review alterations of chromatin that are fundamental to cell responses to metabolic changes due to stress and aging to maintain redox and energy homeostasis. We discuss the relationship between spatiotemporal control of energy and chromatin function, as this emerging concept must be considered to understand how cell homeostasis is maintained.https://doi.org/10.1186/s13072-023-00520-8Chromatin modificationCellular homeostasisEnergyMetabolismAging |
| spellingShingle | Tamaki Suganuma Jerry L. Workman Chromatin balances cell redox and energy homeostasis Epigenetics & Chromatin Chromatin modification Cellular homeostasis Energy Metabolism Aging |
| title | Chromatin balances cell redox and energy homeostasis |
| title_full | Chromatin balances cell redox and energy homeostasis |
| title_fullStr | Chromatin balances cell redox and energy homeostasis |
| title_full_unstemmed | Chromatin balances cell redox and energy homeostasis |
| title_short | Chromatin balances cell redox and energy homeostasis |
| title_sort | chromatin balances cell redox and energy homeostasis |
| topic | Chromatin modification Cellular homeostasis Energy Metabolism Aging |
| url | https://doi.org/10.1186/s13072-023-00520-8 |
| work_keys_str_mv | AT tamakisuganuma chromatinbalancescellredoxandenergyhomeostasis AT jerrylworkman chromatinbalancescellredoxandenergyhomeostasis |