Thrombosis in Chronic Kidney Disease in Children
Venous thromboembolism (VTE) in children is a rare condition. An increased incidence has been observed in the last few years due to several factors, such as increased survival in chronic conditions, especially chronic kidney disease (CKD), use of catheters, and increased sensitivity of diagnostic to...
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MDPI AG
2022-11-01
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author | Tudor Ilie Lazaruc Lavinia Bodescu Amancei Ionescu Vasile Valeriu Lupu Carmen Muntean (Duicu) Roxana Alexandra Bogos Anca Ivanov Georgiana Scurtu Iuliana Magdalena Starcea Ingrith Crenguta Miron Maria Adriana Mocanu |
author_facet | Tudor Ilie Lazaruc Lavinia Bodescu Amancei Ionescu Vasile Valeriu Lupu Carmen Muntean (Duicu) Roxana Alexandra Bogos Anca Ivanov Georgiana Scurtu Iuliana Magdalena Starcea Ingrith Crenguta Miron Maria Adriana Mocanu |
author_sort | Tudor Ilie Lazaruc |
collection | DOAJ |
description | Venous thromboembolism (VTE) in children is a rare condition. An increased incidence has been observed in the last few years due to several factors, such as increased survival in chronic conditions, especially chronic kidney disease (CKD), use of catheters, and increased sensitivity of diagnostic tools. VTE includes deep vein thrombosis (DVT) and pulmonary embolism (PE). VTE in children is associated with a two to six times higher mortality risk and a 5–10% prevalence of post-thrombotic syndrome. Overall, 5% of VTE episodes in children are associated with chronic kidney disease. The etiology of VTE in chronic kidney disease covers a wide range of pathologies. Various types of thrombotic complications may occur during long-term use of a chronic dialysis catheter. VTE occurs in 3% of children with nephrotic syndrome (NS). The risks for VTE and arterial thromboembolism (ATE) were particularly high in the first 6 months after the onset of NS. Other causes of VTE are graft rejection due to thrombosis of vascular anastomoses after kidney transplantation (3%) and autoimmune diseases (lupus nephritis, antiphospholipid syndrome). In this state-of-the-art overview, we have reviewed the physiologic and pathologic mechanisms underlying pediatric thrombosis and updated current diagnostic and treatment options, emphasizing personal experience as well. |
first_indexed | 2024-03-09T17:08:39Z |
format | Article |
id | doaj.art-bd10e83249494e6baef5928ef0fa8a13 |
institution | Directory Open Access Journal |
issn | 2075-4418 |
language | English |
last_indexed | 2024-03-09T17:08:39Z |
publishDate | 2022-11-01 |
publisher | MDPI AG |
record_format | Article |
series | Diagnostics |
spelling | doaj.art-bd10e83249494e6baef5928ef0fa8a132023-11-24T14:15:43ZengMDPI AGDiagnostics2075-44182022-11-011212293110.3390/diagnostics12122931Thrombosis in Chronic Kidney Disease in ChildrenTudor Ilie Lazaruc0Lavinia Bodescu Amancei Ionescu1Vasile Valeriu Lupu2Carmen Muntean (Duicu)3Roxana Alexandra Bogos4Anca Ivanov5Georgiana Scurtu6Iuliana Magdalena Starcea7Ingrith Crenguta Miron8Maria Adriana Mocanu9Department of Pediatrics, “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, RomaniaDepartment of Pediatrics, “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, RomaniaDepartment of Pediatrics, “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, RomaniaDepartment of Pediatrics I, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540088 Targu Mures, RomaniaDepartment of Pediatrics, “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, RomaniaDepartment of Pediatrics, “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, RomaniaDepartment of Pediatrics, “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, RomaniaDepartment of Pediatrics, “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, RomaniaDepartment of Pediatrics, “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, RomaniaDepartment of Pediatrics, “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, RomaniaVenous thromboembolism (VTE) in children is a rare condition. An increased incidence has been observed in the last few years due to several factors, such as increased survival in chronic conditions, especially chronic kidney disease (CKD), use of catheters, and increased sensitivity of diagnostic tools. VTE includes deep vein thrombosis (DVT) and pulmonary embolism (PE). VTE in children is associated with a two to six times higher mortality risk and a 5–10% prevalence of post-thrombotic syndrome. Overall, 5% of VTE episodes in children are associated with chronic kidney disease. The etiology of VTE in chronic kidney disease covers a wide range of pathologies. Various types of thrombotic complications may occur during long-term use of a chronic dialysis catheter. VTE occurs in 3% of children with nephrotic syndrome (NS). The risks for VTE and arterial thromboembolism (ATE) were particularly high in the first 6 months after the onset of NS. Other causes of VTE are graft rejection due to thrombosis of vascular anastomoses after kidney transplantation (3%) and autoimmune diseases (lupus nephritis, antiphospholipid syndrome). In this state-of-the-art overview, we have reviewed the physiologic and pathologic mechanisms underlying pediatric thrombosis and updated current diagnostic and treatment options, emphasizing personal experience as well.https://www.mdpi.com/2075-4418/12/12/2931venous thromboembolismchronic kidney diseasechild |
spellingShingle | Tudor Ilie Lazaruc Lavinia Bodescu Amancei Ionescu Vasile Valeriu Lupu Carmen Muntean (Duicu) Roxana Alexandra Bogos Anca Ivanov Georgiana Scurtu Iuliana Magdalena Starcea Ingrith Crenguta Miron Maria Adriana Mocanu Thrombosis in Chronic Kidney Disease in Children Diagnostics venous thromboembolism chronic kidney disease child |
title | Thrombosis in Chronic Kidney Disease in Children |
title_full | Thrombosis in Chronic Kidney Disease in Children |
title_fullStr | Thrombosis in Chronic Kidney Disease in Children |
title_full_unstemmed | Thrombosis in Chronic Kidney Disease in Children |
title_short | Thrombosis in Chronic Kidney Disease in Children |
title_sort | thrombosis in chronic kidney disease in children |
topic | venous thromboembolism chronic kidney disease child |
url | https://www.mdpi.com/2075-4418/12/12/2931 |
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