Therapeutic Effects of Stimulating the Melanocortin Pathway in Regulating Ocular Inflammation and Cell Death
Alpha-melanocyte-stimulating hormone (α-MSH) and its binding receptors (the melanocortin receptors) play important roles in maintaining ocular tissue integrity and immune homeostasis. Particularly extensive studies have demonstrated the biological functions of α-MSH in both immunoregulation and cyto...
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| Format: | Article |
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MDPI AG
2024-01-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/14/2/169 |
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| author | Shudan Wang Francesca Kahale Amirreza Naderi Pier Luigi Surico Jia Yin Thomas Dohlman Yihe Chen Reza Dana |
| author_facet | Shudan Wang Francesca Kahale Amirreza Naderi Pier Luigi Surico Jia Yin Thomas Dohlman Yihe Chen Reza Dana |
| author_sort | Shudan Wang |
| collection | DOAJ |
| description | Alpha-melanocyte-stimulating hormone (α-MSH) and its binding receptors (the melanocortin receptors) play important roles in maintaining ocular tissue integrity and immune homeostasis. Particularly extensive studies have demonstrated the biological functions of α-MSH in both immunoregulation and cyto-protection. This review summarizes the current knowledge of both the physiological and pathological roles of α-MSH and its receptors in the eye. We focus on recent developments in the biology of α-MSH and the relevant clinical implications in treating ocular diseases. |
| first_indexed | 2024-03-07T22:41:00Z |
| format | Article |
| id | doaj.art-bd11fcf64a794ccea5a931749d9ccd80 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-07T22:41:00Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-bd11fcf64a794ccea5a931749d9ccd802024-02-23T15:09:16ZengMDPI AGBiomolecules2218-273X2024-01-0114216910.3390/biom14020169Therapeutic Effects of Stimulating the Melanocortin Pathway in Regulating Ocular Inflammation and Cell DeathShudan Wang0Francesca Kahale1Amirreza Naderi2Pier Luigi Surico3Jia Yin4Thomas Dohlman5Yihe Chen6Reza Dana7Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USASchepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USASchepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USASchepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USASchepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USASchepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USASchepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USASchepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USAAlpha-melanocyte-stimulating hormone (α-MSH) and its binding receptors (the melanocortin receptors) play important roles in maintaining ocular tissue integrity and immune homeostasis. Particularly extensive studies have demonstrated the biological functions of α-MSH in both immunoregulation and cyto-protection. This review summarizes the current knowledge of both the physiological and pathological roles of α-MSH and its receptors in the eye. We focus on recent developments in the biology of α-MSH and the relevant clinical implications in treating ocular diseases.https://www.mdpi.com/2218-273X/14/2/169α-MSHcyto-protectionimmunoregulationmelanocortin receptorsocular immunityocular pathologies |
| spellingShingle | Shudan Wang Francesca Kahale Amirreza Naderi Pier Luigi Surico Jia Yin Thomas Dohlman Yihe Chen Reza Dana Therapeutic Effects of Stimulating the Melanocortin Pathway in Regulating Ocular Inflammation and Cell Death Biomolecules α-MSH cyto-protection immunoregulation melanocortin receptors ocular immunity ocular pathologies |
| title | Therapeutic Effects of Stimulating the Melanocortin Pathway in Regulating Ocular Inflammation and Cell Death |
| title_full | Therapeutic Effects of Stimulating the Melanocortin Pathway in Regulating Ocular Inflammation and Cell Death |
| title_fullStr | Therapeutic Effects of Stimulating the Melanocortin Pathway in Regulating Ocular Inflammation and Cell Death |
| title_full_unstemmed | Therapeutic Effects of Stimulating the Melanocortin Pathway in Regulating Ocular Inflammation and Cell Death |
| title_short | Therapeutic Effects of Stimulating the Melanocortin Pathway in Regulating Ocular Inflammation and Cell Death |
| title_sort | therapeutic effects of stimulating the melanocortin pathway in regulating ocular inflammation and cell death |
| topic | α-MSH cyto-protection immunoregulation melanocortin receptors ocular immunity ocular pathologies |
| url | https://www.mdpi.com/2218-273X/14/2/169 |
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