Topical Intranasal Fluorescein to Diagnose and Localize Cerebrospinal Fluid Leak: A Systematic Review
Objective:This study evaluates the available evidence regarding using topical intranasal fluorescein (TINF) to diagnose and localize nasal cerebrospinal fluid (CSF) leak.Methods:A literature search was conducted through PubMed, the Cochrane Database, Scopus, and Ovid to identify the articles providi...
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| Format: | Article |
| Language: | English |
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Galenos Yayincilik
2021-09-01
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| Series: | Turkish Archives of Otorhinolaryngology |
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http://turkarchotolaryngol.net/archives/archive-detail/article-preview/topical-ntranasal-fluorescein-to-diagnose-and-loca/49286
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| _version_ | 1797911405861535744 |
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| author | Hussain Albaharna Mohammad Alshareef Saud Alromaih Mohammad Aloulah Saad Alsaleh Ahmad Alroqi |
| author_facet | Hussain Albaharna Mohammad Alshareef Saud Alromaih Mohammad Aloulah Saad Alsaleh Ahmad Alroqi |
| author_sort | Hussain Albaharna |
| collection | DOAJ |
| description | Objective:This study evaluates the available evidence regarding using topical intranasal fluorescein (TINF) to diagnose and localize nasal cerebrospinal fluid (CSF) leak.Methods:A literature search was conducted through PubMed, the Cochrane Database, Scopus, and Ovid to identify the articles providing insight into using TINF to diagnose CSF leak preoperatively or to localize the leak intraoperatively. The articles from the database were screened and filtered by two authors according to the selection criteria. A spreadsheet was created to collect the data including demographic characteristics, the sensitivity and specificity of TINF for diagnosing and localizing a CSF leak, the protocol of applying TINF, and the complications.Results:After excluding duplicates and articles that did not meet our selection criteria, we included five reports in the final analysis. The average age of the 94 participants was 39.5, and there was an equal distribution of males and females. The sensitivity of TINF to make a preoperative diagnosis of CSF leak was 100%, and it was 97% to localize the site intraoperatively. Complications associated with TINF were not reported in any of the reports. This review showed a grade C recommendation based on five case series.Conclusion:Based on the current evidence, TINF cannot be recommended for standard clinical practice. It can, however, be considered in situations where other gold standard tools are unavailable since it is feasible and easy to use. A standardized control trial should be conducted to yield additional unbiased evidence. |
| first_indexed | 2024-04-10T11:39:59Z |
| format | Article |
| id | doaj.art-bd131dfadf60406c96559649ef42dd65 |
| institution | Directory Open Access Journal |
| issn | 2667-7474 |
| language | English |
| last_indexed | 2024-04-10T11:39:59Z |
| publishDate | 2021-09-01 |
| publisher | Galenos Yayincilik |
| record_format | Article |
| series | Turkish Archives of Otorhinolaryngology |
| spelling | doaj.art-bd131dfadf60406c96559649ef42dd652023-02-15T16:17:34ZengGalenos YayincilikTurkish Archives of Otorhinolaryngology2667-74742021-09-0159322322910.4274/tao.2021.2021-3-1213049054Topical Intranasal Fluorescein to Diagnose and Localize Cerebrospinal Fluid Leak: A Systematic ReviewHussain Albaharna0Mohammad Alshareef1Saud Alromaih2Mohammad Aloulah3Saad Alsaleh4Ahmad Alroqi5 Department of Otolaryngology-Head and Neck surgery, Qatif Central Hospital, Qatif, Eastern province, Saudi Arabia Department of Otolaryngology-Head and Neck Surgery, Khamis Mushait General Hospital, Khamis Mushait City, Saudi Arabia Department of Otolaryngology–Head & Neck Surgery, King Saud University, Riyadh, Saudi Arabia Department of Otolaryngology–Head & Neck Surgery, King Saud University, Riyadh, Saudi Arabia Department of Otolaryngology–Head & Neck Surgery, King Saud University, Riyadh, Saudi Arabia Department of Otolaryngology–Head & Neck Surgery, King Saud University, Riyadh, Saudi Arabia Objective:This study evaluates the available evidence regarding using topical intranasal fluorescein (TINF) to diagnose and localize nasal cerebrospinal fluid (CSF) leak.Methods:A literature search was conducted through PubMed, the Cochrane Database, Scopus, and Ovid to identify the articles providing insight into using TINF to diagnose CSF leak preoperatively or to localize the leak intraoperatively. The articles from the database were screened and filtered by two authors according to the selection criteria. A spreadsheet was created to collect the data including demographic characteristics, the sensitivity and specificity of TINF for diagnosing and localizing a CSF leak, the protocol of applying TINF, and the complications.Results:After excluding duplicates and articles that did not meet our selection criteria, we included five reports in the final analysis. The average age of the 94 participants was 39.5, and there was an equal distribution of males and females. The sensitivity of TINF to make a preoperative diagnosis of CSF leak was 100%, and it was 97% to localize the site intraoperatively. Complications associated with TINF were not reported in any of the reports. This review showed a grade C recommendation based on five case series.Conclusion:Based on the current evidence, TINF cannot be recommended for standard clinical practice. It can, however, be considered in situations where other gold standard tools are unavailable since it is feasible and easy to use. A standardized control trial should be conducted to yield additional unbiased evidence. http://turkarchotolaryngol.net/archives/archive-detail/article-preview/topical-ntranasal-fluorescein-to-diagnose-and-loca/49286 cerebrospinal fluid rhinorrheaparanasal sinusesskull basespinal puncturetransferrinsystematic review |
| spellingShingle | Hussain Albaharna Mohammad Alshareef Saud Alromaih Mohammad Aloulah Saad Alsaleh Ahmad Alroqi Topical Intranasal Fluorescein to Diagnose and Localize Cerebrospinal Fluid Leak: A Systematic Review Turkish Archives of Otorhinolaryngology cerebrospinal fluid rhinorrhea paranasal sinuses skull base spinal puncture transferrin systematic review |
| title | Topical Intranasal Fluorescein to Diagnose and Localize Cerebrospinal Fluid Leak: A Systematic Review |
| title_full | Topical Intranasal Fluorescein to Diagnose and Localize Cerebrospinal Fluid Leak: A Systematic Review |
| title_fullStr | Topical Intranasal Fluorescein to Diagnose and Localize Cerebrospinal Fluid Leak: A Systematic Review |
| title_full_unstemmed | Topical Intranasal Fluorescein to Diagnose and Localize Cerebrospinal Fluid Leak: A Systematic Review |
| title_short | Topical Intranasal Fluorescein to Diagnose and Localize Cerebrospinal Fluid Leak: A Systematic Review |
| title_sort | topical intranasal fluorescein to diagnose and localize cerebrospinal fluid leak a systematic review |
| topic | cerebrospinal fluid rhinorrhea paranasal sinuses skull base spinal puncture transferrin systematic review |
| url |
http://turkarchotolaryngol.net/archives/archive-detail/article-preview/topical-ntranasal-fluorescein-to-diagnose-and-loca/49286
|
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