Mineral-Enriched Deep-Sea Water Modulates Lactate Metabolism via PGC-1α-Mediated Metabolic Reprogramming
Metabolic disorders such as diabetes and obesity are serious global health issues. These diseases are accelerated by mineral deficiencies, emphasizing the importance of addressing these deficiencies in disease management plans. Lactate metabolism is fundamentally linked to glucose metabolism, and se...
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MDPI AG
2019-10-01
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Series: | Marine Drugs |
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Online Access: | https://www.mdpi.com/1660-3397/17/11/611 |
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author | Byung Geun Ha Sung Suk Jung You Kyung Jang Byong Yeob Jeon Yun Hee Shon |
author_facet | Byung Geun Ha Sung Suk Jung You Kyung Jang Byong Yeob Jeon Yun Hee Shon |
author_sort | Byung Geun Ha |
collection | DOAJ |
description | Metabolic disorders such as diabetes and obesity are serious global health issues. These diseases are accelerated by mineral deficiencies, emphasizing the importance of addressing these deficiencies in disease management plans. Lactate metabolism is fundamentally linked to glucose metabolism, and several clinical studies have reported that blood lactate levels are higher in obese and diabetic patients than in healthy subjects. Balanced deep-sea water contains various minerals and exhibits antiobesity and antidiabetic activities in mice; however, the impact of balanced deep-sea water on lactate metabolism is unclear. Thus, we evaluated the effects of balanced deep-sea water on lactate metabolism in C2C12 myotubes, and found that balanced deep-sea water mediated lactate metabolism by regulating the gene expression levels of lactate dehydrogenases A and B, a monocarboxylate transporter, and a mitochondrial pyruvate carrier. The activities of peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) and signaling molecules involved in PGC-1α activation were also upregulated by treatment with balanced deep-sea water. These results suggest that balanced deep-sea water, which can mediate lactate metabolism, may be used to prevent or treat obesity and diabetes mellitus. |
first_indexed | 2024-04-11T14:00:49Z |
format | Article |
id | doaj.art-bd1670ead6814bd8969e62775fe8f56c |
institution | Directory Open Access Journal |
issn | 1660-3397 |
language | English |
last_indexed | 2024-04-11T14:00:49Z |
publishDate | 2019-10-01 |
publisher | MDPI AG |
record_format | Article |
series | Marine Drugs |
spelling | doaj.art-bd1670ead6814bd8969e62775fe8f56c2022-12-22T04:20:08ZengMDPI AGMarine Drugs1660-33972019-10-01171161110.3390/md17110611md17110611Mineral-Enriched Deep-Sea Water Modulates Lactate Metabolism via PGC-1α-Mediated Metabolic ReprogrammingByung Geun Ha0Sung Suk Jung1You Kyung Jang2Byong Yeob Jeon3Yun Hee Shon4Biomedical Research Institute, Kyungpook National University Hospital, 50 Samduk 2ga Jung-gu, Daegu 41944, KoreaBiomedical Research Institute, Kyungpook National University Hospital, 50 Samduk 2ga Jung-gu, Daegu 41944, KoreaQBM Co., Ltd., Seoul 06752, KoreaQBM Co., Ltd., Seoul 06752, KoreaBiomedical Research Institute, Kyungpook National University Hospital, 50 Samduk 2ga Jung-gu, Daegu 41944, KoreaMetabolic disorders such as diabetes and obesity are serious global health issues. These diseases are accelerated by mineral deficiencies, emphasizing the importance of addressing these deficiencies in disease management plans. Lactate metabolism is fundamentally linked to glucose metabolism, and several clinical studies have reported that blood lactate levels are higher in obese and diabetic patients than in healthy subjects. Balanced deep-sea water contains various minerals and exhibits antiobesity and antidiabetic activities in mice; however, the impact of balanced deep-sea water on lactate metabolism is unclear. Thus, we evaluated the effects of balanced deep-sea water on lactate metabolism in C2C12 myotubes, and found that balanced deep-sea water mediated lactate metabolism by regulating the gene expression levels of lactate dehydrogenases A and B, a monocarboxylate transporter, and a mitochondrial pyruvate carrier. The activities of peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) and signaling molecules involved in PGC-1α activation were also upregulated by treatment with balanced deep-sea water. These results suggest that balanced deep-sea water, which can mediate lactate metabolism, may be used to prevent or treat obesity and diabetes mellitus.https://www.mdpi.com/1660-3397/17/11/611c2c12 myotubesdeep-sea waterlactate metabolismmetabolic disordersmineral deficiencypgc-1α |
spellingShingle | Byung Geun Ha Sung Suk Jung You Kyung Jang Byong Yeob Jeon Yun Hee Shon Mineral-Enriched Deep-Sea Water Modulates Lactate Metabolism via PGC-1α-Mediated Metabolic Reprogramming Marine Drugs c2c12 myotubes deep-sea water lactate metabolism metabolic disorders mineral deficiency pgc-1α |
title | Mineral-Enriched Deep-Sea Water Modulates Lactate Metabolism via PGC-1α-Mediated Metabolic Reprogramming |
title_full | Mineral-Enriched Deep-Sea Water Modulates Lactate Metabolism via PGC-1α-Mediated Metabolic Reprogramming |
title_fullStr | Mineral-Enriched Deep-Sea Water Modulates Lactate Metabolism via PGC-1α-Mediated Metabolic Reprogramming |
title_full_unstemmed | Mineral-Enriched Deep-Sea Water Modulates Lactate Metabolism via PGC-1α-Mediated Metabolic Reprogramming |
title_short | Mineral-Enriched Deep-Sea Water Modulates Lactate Metabolism via PGC-1α-Mediated Metabolic Reprogramming |
title_sort | mineral enriched deep sea water modulates lactate metabolism via pgc 1α mediated metabolic reprogramming |
topic | c2c12 myotubes deep-sea water lactate metabolism metabolic disorders mineral deficiency pgc-1α |
url | https://www.mdpi.com/1660-3397/17/11/611 |
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