Antibody gene transfer treatment drastically improves epidermal pathology in a keratitis ichthyosis deafness syndrome model using male miceResearch in context

Antibody gene transfer treatment drastically improves epidermal pathology in a keratitis ichthyosis deafness syndrome model using male miceResearch in context

Summary: Background: Keratitis ichthyosis deafness (KID) syndrome is a rare disorder caused by hemichannel (HC) activating gain-of-function mutations in the GJB2 gene encoding connexin (Cx) 26, for which there is no cure, or current treatments based upon the mechanism of disease causation. Methods:...

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Bibliographic Details
Main Authors: Chiara Peres, Caterina Sellitto, Chiara Nardin, Sabrina Putti, Tiziana Orsini, Chiara Di Pietro, Daniela Marazziti, Adriana Vitiello, Arianna Calistri, Mara Rigamonti, Ferdinando Scavizzi, Marcello Raspa, Francesco Zonta, Guang Yang, Thomas W. White, Fabio Mammano
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:EBioMedicine
Subjects:
Genodermatosis
Connexin 26
Adeno-associated viral vectors
In vivo preclinical study
Online Access:http://www.sciencedirect.com/science/article/pii/S235239642300018X

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http://www.sciencedirect.com/science/article/pii/S235239642300018X

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