The autism-associated protein CHD8 is required for cerebellar development and motor function

The autism-associated protein CHD8 is required for cerebellar development and motor function

Summary: Mutations in the gene encoding the chromatin remodeler chromodomain helicase DNA-binding protein 8 (CHD8) are a highly penetrant risk factor for autism spectrum disorder (ASD). Although cerebellar abnormalities have long been thought to be related to ASD pathogenesis, it has remained largel...

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Bibliographic Details
Main Authors: Atsuki Kawamura, Yuta Katayama, Wataru Kakegawa, Daisuke Ino, Masaaki Nishiyama, Michisuke Yuzaki, Keiichi I. Nakayama
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Cell Reports
Subjects:
autism spectrum disorder
cerebellum
chromatin-remodeling factor
CHD8
granule neuron
Purkinje cell
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721002461

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