Label-Free Monitoring of Diffusion in Microfluidics
Label-free, real-time detection of concentration gradients is demonstrated in a microfluidic H-filter, using an integrated photonic crystal slab sensor to monitor sample refractive index with spatial resolution. The recorded diffusion profiles reveal root-mean-square diffusion lengths for non-fluore...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2017-11-01
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| Series: | Micromachines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-666X/8/11/329 |
| _version_ | 1811236771888889856 |
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| author | Kristian Tølbøl Sørensen Anders Kristensen |
| author_facet | Kristian Tølbøl Sørensen Anders Kristensen |
| author_sort | Kristian Tølbøl Sørensen |
| collection | DOAJ |
| description | Label-free, real-time detection of concentration gradients is demonstrated in a microfluidic H-filter, using an integrated photonic crystal slab sensor to monitor sample refractive index with spatial resolution. The recorded diffusion profiles reveal root-mean-square diffusion lengths for non-fluorescing and non-absorbing molecules, both small (glucose, 180 Da) and large (bovine serum albumin, 67 kDa). |
| first_indexed | 2024-04-12T12:13:53Z |
| format | Article |
| id | doaj.art-bd1c770eeb994e6296dd9d72a17bf387 |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-04-12T12:13:53Z |
| publishDate | 2017-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-bd1c770eeb994e6296dd9d72a17bf3872022-12-22T03:33:29ZengMDPI AGMicromachines2072-666X2017-11-0181132910.3390/mi8110329mi8110329Label-Free Monitoring of Diffusion in MicrofluidicsKristian Tølbøl Sørensen0Anders Kristensen1Department of Micro- and Nanotechnology, Technical University of Denmark, Kongens Lyngby 2800, DenmarkDepartment of Micro- and Nanotechnology, Technical University of Denmark, Kongens Lyngby 2800, DenmarkLabel-free, real-time detection of concentration gradients is demonstrated in a microfluidic H-filter, using an integrated photonic crystal slab sensor to monitor sample refractive index with spatial resolution. The recorded diffusion profiles reveal root-mean-square diffusion lengths for non-fluorescing and non-absorbing molecules, both small (glucose, 180 Da) and large (bovine serum albumin, 67 kDa).https://www.mdpi.com/2072-666X/8/11/329optofluidicsmicrofluidicsdiffusionconvectionmixingrefractive indexlabel-free |
| spellingShingle | Kristian Tølbøl Sørensen Anders Kristensen Label-Free Monitoring of Diffusion in Microfluidics Micromachines optofluidics microfluidics diffusion convection mixing refractive index label-free |
| title | Label-Free Monitoring of Diffusion in Microfluidics |
| title_full | Label-Free Monitoring of Diffusion in Microfluidics |
| title_fullStr | Label-Free Monitoring of Diffusion in Microfluidics |
| title_full_unstemmed | Label-Free Monitoring of Diffusion in Microfluidics |
| title_short | Label-Free Monitoring of Diffusion in Microfluidics |
| title_sort | label free monitoring of diffusion in microfluidics |
| topic | optofluidics microfluidics diffusion convection mixing refractive index label-free |
| url | https://www.mdpi.com/2072-666X/8/11/329 |
| work_keys_str_mv | AT kristiantølbølsørensen labelfreemonitoringofdiffusioninmicrofluidics AT anderskristensen labelfreemonitoringofdiffusioninmicrofluidics |