Variants in RETN gene are associated with steroid-induced osteonecrosis of the femoral head risk among Han Chinese people
Abstract Background Gene polymorphism has an important influence on RETN gene expression level, and the increased level of resistin encoded in RETN will lead to metabolic disorder, especially lipid metabolism. Moreover, steroid-induced osteonecrosis of the femoral head (steroid-induced ONFH) is clos...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-03-01
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| Series: | Journal of Orthopaedic Surgery and Research |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13018-020-1557-3 |
| _version_ | 1811262681519226880 |
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| author | Feimeng An Litian Zhang Hongyan Gao Jiaqi Wang Chang Liu Ye Tian Chao Ma Jian Zhao Kunzheng Wang Jianzhong Wang |
| author_facet | Feimeng An Litian Zhang Hongyan Gao Jiaqi Wang Chang Liu Ye Tian Chao Ma Jian Zhao Kunzheng Wang Jianzhong Wang |
| author_sort | Feimeng An |
| collection | DOAJ |
| description | Abstract Background Gene polymorphism has an important influence on RETN gene expression level, and the increased level of resistin encoded in RETN will lead to metabolic disorder, especially lipid metabolism. Moreover, steroid-induced osteonecrosis of the femoral head (steroid-induced ONFH) is closely related to lipid metabolism level, so this study is intended to explore the relationship of RETN polymorphisms with susceptibility to steroid-induced ONFH in the Chinese Han population. Methods In this case-control study, eight single-nucleotide polymorphisms (SNPs) of RETN were genotyped by the Agena MassARRAY system in 199 steroid-induced ONFH patients and 200 healthy controls. The relationship between RETN polymorphisms and steroid-induced ONFH risk was assessed using genetic models and haplotype analyses. Odds ratio (OR) and 95% confidence intervals (CIs) were obtained by logistic regression adjusted for age. Results We found significant differences in the distribution of HDL-C, TG/HDL-C, and LDL-C/HDL-C between the patients and the control group (p < 0.05). In allele model and genotype model analysis, rs34861192, rs3219175, rs3745368, and rs1477341 could reduce the risk of steroid-induced ONFH. Further stratified analysis showed that rs3745367 was related to the clinical stage of patients, and rs1477341 was significantly correlated with an increased TG level and a decreased TC/HDL-C level. The linkage analysis showed that two SNPs (rs34861192 and rs3219175) in RETN even significant linkage disequilibrium. Conclusions Our results provide the firstly evidence that RETN gene polymorphisms were associated with a reduced risk of steroid-induced ONFH in Chinese Han population. |
| first_indexed | 2024-04-12T19:30:03Z |
| format | Article |
| id | doaj.art-bd1d7ce4c1864ef59380c1c6f38a6a34 |
| institution | Directory Open Access Journal |
| issn | 1749-799X |
| language | English |
| last_indexed | 2024-04-12T19:30:03Z |
| publishDate | 2020-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj.art-bd1d7ce4c1864ef59380c1c6f38a6a342022-12-22T03:19:22ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2020-03-011511810.1186/s13018-020-1557-3Variants in RETN gene are associated with steroid-induced osteonecrosis of the femoral head risk among Han Chinese peopleFeimeng An0Litian Zhang1Hongyan Gao2Jiaqi Wang3Chang Liu4Ye Tian5Chao Ma6Jian Zhao7Kunzheng Wang8Jianzhong Wang9Inner Mongolia Medical UniversityInner Mongolia Medical UniversityInner Mongolia Medical UniversityInner Mongolia Medical UniversityInner Mongolia Medical UniversityInner Mongolia Medical UniversityInner Mongolia Medical UniversityInner Mongolia Medical UniversityThe Second Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Trauma Orthopedics, The Second Affiliated Hospital of Inner Mongolia Medical UniversityAbstract Background Gene polymorphism has an important influence on RETN gene expression level, and the increased level of resistin encoded in RETN will lead to metabolic disorder, especially lipid metabolism. Moreover, steroid-induced osteonecrosis of the femoral head (steroid-induced ONFH) is closely related to lipid metabolism level, so this study is intended to explore the relationship of RETN polymorphisms with susceptibility to steroid-induced ONFH in the Chinese Han population. Methods In this case-control study, eight single-nucleotide polymorphisms (SNPs) of RETN were genotyped by the Agena MassARRAY system in 199 steroid-induced ONFH patients and 200 healthy controls. The relationship between RETN polymorphisms and steroid-induced ONFH risk was assessed using genetic models and haplotype analyses. Odds ratio (OR) and 95% confidence intervals (CIs) were obtained by logistic regression adjusted for age. Results We found significant differences in the distribution of HDL-C, TG/HDL-C, and LDL-C/HDL-C between the patients and the control group (p < 0.05). In allele model and genotype model analysis, rs34861192, rs3219175, rs3745368, and rs1477341 could reduce the risk of steroid-induced ONFH. Further stratified analysis showed that rs3745367 was related to the clinical stage of patients, and rs1477341 was significantly correlated with an increased TG level and a decreased TC/HDL-C level. The linkage analysis showed that two SNPs (rs34861192 and rs3219175) in RETN even significant linkage disequilibrium. Conclusions Our results provide the firstly evidence that RETN gene polymorphisms were associated with a reduced risk of steroid-induced ONFH in Chinese Han population.http://link.springer.com/article/10.1186/s13018-020-1557-3Steroid-induced osteonecrosis of the femoral head (steroid-induced ONFH)Resistin (RETN)Genetic polymorphismsCase-control study |
| spellingShingle | Feimeng An Litian Zhang Hongyan Gao Jiaqi Wang Chang Liu Ye Tian Chao Ma Jian Zhao Kunzheng Wang Jianzhong Wang Variants in RETN gene are associated with steroid-induced osteonecrosis of the femoral head risk among Han Chinese people Journal of Orthopaedic Surgery and Research Steroid-induced osteonecrosis of the femoral head (steroid-induced ONFH) Resistin (RETN) Genetic polymorphisms Case-control study |
| title | Variants in RETN gene are associated with steroid-induced osteonecrosis of the femoral head risk among Han Chinese people |
| title_full | Variants in RETN gene are associated with steroid-induced osteonecrosis of the femoral head risk among Han Chinese people |
| title_fullStr | Variants in RETN gene are associated with steroid-induced osteonecrosis of the femoral head risk among Han Chinese people |
| title_full_unstemmed | Variants in RETN gene are associated with steroid-induced osteonecrosis of the femoral head risk among Han Chinese people |
| title_short | Variants in RETN gene are associated with steroid-induced osteonecrosis of the femoral head risk among Han Chinese people |
| title_sort | variants in retn gene are associated with steroid induced osteonecrosis of the femoral head risk among han chinese people |
| topic | Steroid-induced osteonecrosis of the femoral head (steroid-induced ONFH) Resistin (RETN) Genetic polymorphisms Case-control study |
| url | http://link.springer.com/article/10.1186/s13018-020-1557-3 |
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