The predictive role of serum magnesium in prognosis of critically ill medical patients
Introduction: Magnesium deficiency is a common disorder, but easily ignored as compared to other electrolyte abnormalities. Other studies are showing varied prevalence and increased association with morbidity and mortality. Aims & Objectives: The aim of our study is to find out the prevalence of...
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Al Ameen Medical College
2023-07-01
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| Series: | Al Ameen Journal of Medical Sciences |
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| Online Access: | http://ajms.alameenmedical.org/ArticlePDFs/5%20AJMS%20V16.N3.2023%20p%20210-215.pdf |
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| author | M. Rasheed Khan S. Sheela Samini Seelan A.G. Thivyahprabha K. Durga Sowmithri |
| author_facet | M. Rasheed Khan S. Sheela Samini Seelan A.G. Thivyahprabha K. Durga Sowmithri |
| author_sort | M. Rasheed Khan |
| collection | DOAJ |
| description | Introduction: Magnesium deficiency is a common disorder, but easily ignored as compared to other electrolyte abnormalities. Other studies are showing varied prevalence and increased association with morbidity and mortality. Aims & Objectives: The aim of our study is to find out the prevalence of hypomagnesemia among the critically ill medical patients and to correlate the serum magnesium levels with the mortality and morbidity outcome considering the length of ICU stay, duration of ventilatory support, APACHE 2 score, SOFA score, primary medical conditions in critically ill patients in medical ICU. Methodology: This prospective observational study was conducted in Medical intensive care unit of a tertiary care hospital. After the approval from Institutional ethical committee patients admitted to the medical intensive care unit with age more than 12 years and admitted for more than 2 days were included in the study after obtaining written informed consent. Laboratory tests and radiological investigations were done. APACHE 2(acute physiology and chronic health evaluation) score, SOFA score, total ICU stay, hospital stay, need of mechanical ventilation, duration of ventilatory assistance and associated medical conditions like diabetes, sepsis and electrolyte abnormalities were followed up to assess the relation with mortality and morbidity. Results: Among total of 170 critically ill medical patients were included in the study, prevalence of hypomagnesemia was 56.8 %. The morbidity was higher in hypomagnesaemic patients (48.5% vs 23.4%), longer ICU stay (6.96 ± 3.85 vs 5.12 ± 1.31) and need of mechanical ventilation was also more (68.9% vs 40.4 % p value < 0.003). Sepsis and maximum SOFA score indicate being the predominant underlying factor for hypomagnesemia. Even though association was there between mortality and hypomagnesemia, mortality has not correlated significantly [beta -0.041, t -0.473, 95 % CI -0.219 and 0.138]. Conclusion: Hypomagnesemia is more prevalent among the critically ill medical patients. Hypomagnesemia was also associated with increased mortality, longer ICU stay, higher APACHE 2 score, SOFA score, frequent ventilatory support and significant electrolyte abnormalities also. |
| first_indexed | 2024-03-13T00:48:42Z |
| format | Article |
| id | doaj.art-bd226825965d43a48fe013f5ed1493c3 |
| institution | Directory Open Access Journal |
| issn | 0974-1143 |
| language | English |
| last_indexed | 2024-03-13T00:48:42Z |
| publishDate | 2023-07-01 |
| publisher | Al Ameen Medical College |
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| series | Al Ameen Journal of Medical Sciences |
| spelling | doaj.art-bd226825965d43a48fe013f5ed1493c32023-07-08T13:14:54ZengAl Ameen Medical CollegeAl Ameen Journal of Medical Sciences0974-11432023-07-011603210215The predictive role of serum magnesium in prognosis of critically ill medical patientsM. Rasheed Khan0S. Sheela Samini Seelan1A.G. Thivyahprabha2K. Durga Sowmithri3Department of Biochemistry, Srinivasan Medical College & Hospital, Dhanalakshmi Srinivasan University, Tiruchirappalli-621112, Tamil Nadu, IndiaDepartment of General Medicine, Trichy SRM Medical College Hospital & Research Centre, SRM Nagar, Trichy-621105, Tamil Nadu, IndiaDepartment of Biochemistry, St. Peter’s Medical College Hospital & Research Institute, Dr MGR Nagar, Near AERI Campus, Opp SIPCOT –II, Hosur-635130, Krishnagiri District, Tamil Nadu, IndiaDepartment of Biochemistry, Srinivasan Medical College & Hospital, Dhanalakshmi Srinivasan University, Tiruchirappalli-621112, Tamil Nadu, IndiaIntroduction: Magnesium deficiency is a common disorder, but easily ignored as compared to other electrolyte abnormalities. Other studies are showing varied prevalence and increased association with morbidity and mortality. Aims & Objectives: The aim of our study is to find out the prevalence of hypomagnesemia among the critically ill medical patients and to correlate the serum magnesium levels with the mortality and morbidity outcome considering the length of ICU stay, duration of ventilatory support, APACHE 2 score, SOFA score, primary medical conditions in critically ill patients in medical ICU. Methodology: This prospective observational study was conducted in Medical intensive care unit of a tertiary care hospital. After the approval from Institutional ethical committee patients admitted to the medical intensive care unit with age more than 12 years and admitted for more than 2 days were included in the study after obtaining written informed consent. Laboratory tests and radiological investigations were done. APACHE 2(acute physiology and chronic health evaluation) score, SOFA score, total ICU stay, hospital stay, need of mechanical ventilation, duration of ventilatory assistance and associated medical conditions like diabetes, sepsis and electrolyte abnormalities were followed up to assess the relation with mortality and morbidity. Results: Among total of 170 critically ill medical patients were included in the study, prevalence of hypomagnesemia was 56.8 %. The morbidity was higher in hypomagnesaemic patients (48.5% vs 23.4%), longer ICU stay (6.96 ± 3.85 vs 5.12 ± 1.31) and need of mechanical ventilation was also more (68.9% vs 40.4 % p value < 0.003). Sepsis and maximum SOFA score indicate being the predominant underlying factor for hypomagnesemia. Even though association was there between mortality and hypomagnesemia, mortality has not correlated significantly [beta -0.041, t -0.473, 95 % CI -0.219 and 0.138]. Conclusion: Hypomagnesemia is more prevalent among the critically ill medical patients. Hypomagnesemia was also associated with increased mortality, longer ICU stay, higher APACHE 2 score, SOFA score, frequent ventilatory support and significant electrolyte abnormalities also.http://ajms.alameenmedical.org/ArticlePDFs/5%20AJMS%20V16.N3.2023%20p%20210-215.pdfhypomagnesemiamortalitycriticallyill patientssepsisapache score |
| spellingShingle | M. Rasheed Khan S. Sheela Samini Seelan A.G. Thivyahprabha K. Durga Sowmithri The predictive role of serum magnesium in prognosis of critically ill medical patients Al Ameen Journal of Medical Sciences hypomagnesemia mortality criticallyill patients sepsis apache score |
| title | The predictive role of serum magnesium in prognosis of critically ill medical patients |
| title_full | The predictive role of serum magnesium in prognosis of critically ill medical patients |
| title_fullStr | The predictive role of serum magnesium in prognosis of critically ill medical patients |
| title_full_unstemmed | The predictive role of serum magnesium in prognosis of critically ill medical patients |
| title_short | The predictive role of serum magnesium in prognosis of critically ill medical patients |
| title_sort | predictive role of serum magnesium in prognosis of critically ill medical patients |
| topic | hypomagnesemia mortality criticallyill patients sepsis apache score |
| url | http://ajms.alameenmedical.org/ArticlePDFs/5%20AJMS%20V16.N3.2023%20p%20210-215.pdf |
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