Amlodipine Ameliorates Up-Regulation of ET-1 in Left Ventricle of Hypercholesterolemia Rabbits
Objective(s)In addition to antihypertensive effects, amlodipine may exhibit cardiovascular protective effects in heart tissue. The aim of this study was to evaluate the effects of amlodipine and/or high cholesterol diet on blood, heart tissue concentration and mRNA expression of endothelin-1 (ET-1)...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2010-09-01
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| Series: | Iranian Journal of Basic Medical Sciences |
| Subjects: | |
| Online Access: | http://www.mums.ac.ir/shares/basic_medical/basicmedjou/89/fall/a11.pdf |
| _version_ | 1828290926133379072 |
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| author | Iraj Salehi Safar Farajnia Mustafa Mohammadi Masoud Sabouri Ghannad |
| author_facet | Iraj Salehi Safar Farajnia Mustafa Mohammadi Masoud Sabouri Ghannad |
| author_sort | Iraj Salehi |
| collection | DOAJ |
| description | Objective(s)In addition to antihypertensive effects, amlodipine may exhibit cardiovascular protective effects in heart tissue. The aim of this study was to evaluate the effects of amlodipine and/or high cholesterol diet on blood, heart tissue concentration and mRNA expression of endothelin-1 (ET-1) in male New Zealand white rabbits.Materials and MethodsA total of 40 male New Zealand rabbits were divided into four groups: the normal control group, normal group receiving amlodipine, high-cholesterol diet group and high-cholesterol diet with amlodipine group. After 8 weeks, all the animals anesthetized and blood or tissues samples were collected.ResultsAfter 8 weeks of a high cholesterol diet, the group with such a diet had a significantly higher ratio of left ventricle (LV) weight to body weight than the control group (P= 0.0001). After treatment with amlodipine for 8 weeks, ET-1 level was reduced considerably in comparison with the control (P= 0.01) and high-cholesterol diet groupes (P= 0.01). Amlodipine consumption caused significant reduction (P= 0.01) in the level of ET-1 in heart tissues of high-cholesterol diet group but it had no remarkable effect on the reduction of heart tissue ET-1 in amlodipine group compared with the control group. ConclusionThe present study demonstrates that ventricular prepro-ET-1 mRNA quantitatively increases in the high-cholesterol diet rabbits which results in development of ventricular hypertrophy. It seems that the treatment with amlodipine retards the progression of LV hypertrophy through attenuation of ET-1 levels independent of lipid changes. |
| first_indexed | 2024-04-13T10:43:51Z |
| format | Article |
| id | doaj.art-bd2533ee3829499191261b040665701c |
| institution | Directory Open Access Journal |
| issn | 2008-3866 2008-3874 |
| language | English |
| last_indexed | 2024-04-13T10:43:51Z |
| publishDate | 2010-09-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Basic Medical Sciences |
| spelling | doaj.art-bd2533ee3829499191261b040665701c2022-12-22T02:49:51ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742010-09-011347Amlodipine Ameliorates Up-Regulation of ET-1 in Left Ventricle of Hypercholesterolemia RabbitsIraj SalehiSafar FarajniaMustafa MohammadiMasoud Sabouri GhannadObjective(s)In addition to antihypertensive effects, amlodipine may exhibit cardiovascular protective effects in heart tissue. The aim of this study was to evaluate the effects of amlodipine and/or high cholesterol diet on blood, heart tissue concentration and mRNA expression of endothelin-1 (ET-1) in male New Zealand white rabbits.Materials and MethodsA total of 40 male New Zealand rabbits were divided into four groups: the normal control group, normal group receiving amlodipine, high-cholesterol diet group and high-cholesterol diet with amlodipine group. After 8 weeks, all the animals anesthetized and blood or tissues samples were collected.ResultsAfter 8 weeks of a high cholesterol diet, the group with such a diet had a significantly higher ratio of left ventricle (LV) weight to body weight than the control group (P= 0.0001). After treatment with amlodipine for 8 weeks, ET-1 level was reduced considerably in comparison with the control (P= 0.01) and high-cholesterol diet groupes (P= 0.01). Amlodipine consumption caused significant reduction (P= 0.01) in the level of ET-1 in heart tissues of high-cholesterol diet group but it had no remarkable effect on the reduction of heart tissue ET-1 in amlodipine group compared with the control group. ConclusionThe present study demonstrates that ventricular prepro-ET-1 mRNA quantitatively increases in the high-cholesterol diet rabbits which results in development of ventricular hypertrophy. It seems that the treatment with amlodipine retards the progression of LV hypertrophy through attenuation of ET-1 levels independent of lipid changes.http://www.mums.ac.ir/shares/basic_medical/basicmedjou/89/fall/a11.pdfAmlodipineEndothelin-1HyperlipidemiasHypertrophyRabbits |
| spellingShingle | Iraj Salehi Safar Farajnia Mustafa Mohammadi Masoud Sabouri Ghannad Amlodipine Ameliorates Up-Regulation of ET-1 in Left Ventricle of Hypercholesterolemia Rabbits Iranian Journal of Basic Medical Sciences Amlodipine Endothelin-1 Hyperlipidemias Hypertrophy Rabbits |
| title | Amlodipine Ameliorates Up-Regulation of ET-1 in Left Ventricle of Hypercholesterolemia Rabbits |
| title_full | Amlodipine Ameliorates Up-Regulation of ET-1 in Left Ventricle of Hypercholesterolemia Rabbits |
| title_fullStr | Amlodipine Ameliorates Up-Regulation of ET-1 in Left Ventricle of Hypercholesterolemia Rabbits |
| title_full_unstemmed | Amlodipine Ameliorates Up-Regulation of ET-1 in Left Ventricle of Hypercholesterolemia Rabbits |
| title_short | Amlodipine Ameliorates Up-Regulation of ET-1 in Left Ventricle of Hypercholesterolemia Rabbits |
| title_sort | amlodipine ameliorates up regulation of et 1 in left ventricle of hypercholesterolemia rabbits |
| topic | Amlodipine Endothelin-1 Hyperlipidemias Hypertrophy Rabbits |
| url | http://www.mums.ac.ir/shares/basic_medical/basicmedjou/89/fall/a11.pdf |
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