Regulation of cholesterol-7α-hydroxylase: BAREly missing a SHP

Regulation of cholesterol-7α-hydroxylase: BAREly missing a SHP

Cholesterol-7α-hydroxylase (CYP7A1) regulates the pathway through which cholesterol is converted into bile acids. The unique detergent properties of bile acids are essential for the digestion and intestinal absorption of hydrophobic nutrients. Bile acids have potent toxic properties (e.g., membrane...

Full description

Bibliographic Details
Main Authors:	Roger A. Davis, Jon H. Miyake, To Yuen Hui, Nathanael J. Spann
Format:	Article
Language:	English
Published:	Elsevier 2002-04-01
Series:	Journal of Lipid Research
Subjects:	bile acid biosynthesis FXR cytokines
Online Access:	http://www.sciencedirect.com/science/article/pii/S0022227520314826

Similar Items

A putative role of micro RNA in regulation of cholesterol 7α-hydroxylase expression in human hepatocytes[S]
by: Kwang-Hoon Song, et al.
Published: (2010-08-01)

Muricholic Acids Promote Resistance to Hypercholesterolemia in Cholesterol-Fed Mice
by: Dany Gaillard, et al.
Published: (2021-07-01)

Effects of cholesterol-lowering probiotics on non-alcoholic fatty liver disease in FXR gene knockout mice
by: Minghua Yang, et al.
Published: (2023-07-01)

Expression of cholesterol-7α-hydroxylase in murine macrophages prevents cholesterol loading by acetyl-LDL
by: Gina L. Moore, et al.
Published: (2002-04-01)

Up to date on cholesterol 7 alpha-hydroxylase (CYP7A1) in bile acid synthesis
by: John Y.L. Chiang, et al.
Published: (2020-06-01)

Alterations in the gut microbiota and serum metabolomics of spontaneous cholestasis caused by loss of FXR signal in mice
by: Shizhang Wei, et al.
Published: (2023-05-01)

FXR Signaling-Mediated Bile Acid Metabolism Is Critical for Alleviation of Cholesterol Gallstones by Lactobacillus Strains
by: Xin Ye, et al.
Published: (2022-10-01)

Cholecystectomy prevents expansion of the bile acid pool and inhibition of cholesterol 7α-hydroxylase in rabbits fed cholesterol
by: Guorong Xu, et al.
Published: (2001-09-01)

Intratracheal exposure to polyhexamethylene guanidine phosphate disrupts coordinate regulation of FXR-SHP-mediated cholesterol and bile acid homeostasis in mouse liver
by: You-Jin Choi, et al.
Published: (2022-12-01)

Improvement of NASH and liver fibrosis through modulation of the gut-liver axis by a novel intestinal FXR agonist
by: An-Na Moon, et al.
Published: (2024-04-01)

Bile Acids Induce Neurite Outgrowth in Nsc-34 Cells via TGR5 and a Distinct Transcriptional Profile
by: Hayley D. Ackerman, et al.
Published: (2023-01-01)

Commentary: Can FXR serve as a potential target for COVID-19 prevention?
by: Juan Pang, et al.
Published: (2023-04-01)

Dietary acetic acid suppress high-fat diet-induced obesity in mice by altering taurine conjugated bile acids metabolism
by: Rui Wang, et al.
Published: (2022-01-01)

Bile Acids and Cancer: Direct and Environmental-Dependent Effects
by: Agostino Di Ciaula, et al.
Published: (2017-11-01)

FXR activation promotes intestinal cholesterol excretion and attenuates hyperlipidemia in SR‐B1‐deficient mice fed a high‐fat and high‐cholesterol diet
by: Amar B. Singh, et al.
Published: (2020-03-01)

Functional and Phylogenetic Diversity of BSH and PVA Enzymes
by: Jack W. Daly, et al.
Published: (2021-03-01)

Alternate pathways of bile acid synthesis in the cholesterol 7α-hydroxylase knockout mouse are not upregulated by either cholesterol or cholestyramine feeding
by: Margrit Schwarz, et al.
Published: (2001-10-01)

Aspirin Caused Intestinal Damage through FXR and ET-1 Signaling Pathways
by: Qiuxia Lin, et al.
Published: (2024-03-01)

The growth-promoting and lipid-lowering effects of berberine are associated with the regulation of intestinal bacteria and bile acid profiles in yellow catfish (Pelteobagrus fulvidraco)
by: Lei Wang, et al.
Published: (2023-12-01)

Bile Acids in Autoimmune Liver Disease: Unveiling the Nexus of Inflammation, Inflammatory Cells, and Treatment Strategies
by: Tianhao Zhou, et al.
Published: (2023-11-01)

Dietary bile acids improve breast muscle growth in chickens through FXR/IGF2 pathway
by: Liang Chen, et al.
Published: (2024-02-01)

Linking Nonalcoholic Fatty Liver Disease and Brain Disease: Focusing on Bile Acid Signaling
by: Zi-Lin Ren, et al.
Published: (2022-10-01)

Geniposide plus chlorogenic acid reverses non-alcoholic steatohepatitis via regulation of gut microbiota and bile acid signaling in a mouse model in vivo
by: Hongshan Li, et al.
Published: (2023-04-01)

Gardenia Iridoid Glucosides Protect Against α-Naphthalene Isothiocya-Nate-Induced Cholestatic Rats Through Activation of the FXR-SHP Signaling Pathway
by: Xu M, et al.
Published: (2023-12-01)

Cholesterol 7α-hydroxylase-deficient mice are protected from high-fat/high-cholesterol diet-induced metabolic disorders[S]
by: Jessica M. Ferrell, et al.
Published: (2016-07-01)

Non-steroidal FXR agonist cilofexor improves cholestatic liver injury in the Mdr2-/- mouse model of sclerosing cholangitis
by: Claudia D. Fuchs, et al.
Published: (2023-11-01)

Bile acid-mediated signaling in cholestatic liver diseases
by: Jing Zeng, et al.
Published: (2023-04-01)

Intestinal Farnesoid X Receptor Activation by Pharmacologic Inhibition of the Organic Solute Transporter α-β
by: Sandra M.W. van de Wiel, et al.
Published: (2018-01-01)

The Role of Gut Microbiota-Derived Lithocholic Acid, Deoxycholic Acid and Their Derivatives on the Function and Differentiation of Immune Cells
by: Yoshimitsu Kiriyama, et al.
Published: (2023-11-01)

Dietary Resistant Starch Regulates Bile Acid Metabolism by Modulating the FXR/LRH-1 Signaling Pathway in Broilers
by: Zhenxin Wang, et al.
Published: (2023-11-01)

HuangQi ChiFeng decoction maintains gut microbiota and bile acid homeostasis through FXR signaling to improve atherosclerosis
by: Jiaqi Fu, et al.
Published: (2023-11-01)

Bile Acids and GPBAR-1: Dynamic Interaction Involving Genes, Environment and Gut Microbiome
by: Piero Portincasa, et al.
Published: (2020-11-01)

Maternal and Fetal Bile Acid Homeostasis Regulated by Sulfated Progesterone Metabolites through FXR Signaling Pathway in a Pregnant Sow Model
by: Peng Wang, et al.
Published: (2022-06-01)

Physiological Role of Bile Acids Modified by the Gut Microbiome
by: Yoshimitsu Kiriyama, et al.
Published: (2021-12-01)

Small intestinal taurochenodeoxycholic acid-FXR axis alters local nutrient-sensing glucoregulatory pathways in rats
by: T.M. Zaved Waise, et al.
Published: (2021-02-01)

Bile Acid Signaling Pathways from the Enterohepatic Circulation to the Central Nervous System
by: Kim L. Mertens, et al.
Published: (2017-11-01)

Recent Advances in the Digestive, Metabolic and Therapeutic Effects of Farnesoid X Receptor and Fibroblast Growth Factor 19: From Cholesterol to Bile Acid Signaling
by: Agostino Di Ciaula, et al.
Published: (2022-11-01)

Nuclear receptor-mediated repression of human cholesterol 7α-hydroxylase gene transcription by bile acids
by: Wenling Chen, et al.
Published: (2001-09-01)

The regulatory role of bile acid microbiota in the progression of liver cirrhosis
by: Feng Zhu, et al.
Published: (2023-06-01)

The Cerebrospinal Fluid Profile of Cholesterol Metabolites in Parkinson’s Disease and Their Association With Disease State and Clinical Features
by: William J. Griffiths, et al.
Published: (2021-08-01)