Efficacy of intravenous acetaminophen in multimodal management for pain relief following total knee arthroplasty: a meta-analysis
Abstract Background The efficacy of intravenous acetaminophen in multimodal pain management in patients undergoing total knee arthroplasty (TKA) is controversial. The purpose of this meta-analysis was to compare the efficacy of intravenous acetaminophen versus placebo in TKA. Methods Randomized cont...
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| Format: | Article |
| Language: | English |
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BMC
2018-10-01
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| Series: | Journal of Orthopaedic Surgery and Research |
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| Online Access: | http://link.springer.com/article/10.1186/s13018-018-0950-7 |
| _version_ | 1798002723729178624 |
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| author | Song-bo Shi Xing-bo Wang Jian-min Song Shi-fang Guo Zhi-xin Chen Yin Wang |
| author_facet | Song-bo Shi Xing-bo Wang Jian-min Song Shi-fang Guo Zhi-xin Chen Yin Wang |
| author_sort | Song-bo Shi |
| collection | DOAJ |
| description | Abstract Background The efficacy of intravenous acetaminophen in multimodal pain management in patients undergoing total knee arthroplasty (TKA) is controversial. The purpose of this meta-analysis was to compare the efficacy of intravenous acetaminophen versus placebo in TKA. Methods Randomized controlled trials (RCTs) or retrospective cohort studies (RCSs) concerning related topics were retrieved from PubMed (1996–June 2018), Embase (1980–June 2018), and the Cochrane Library (CENTRAL June 2018). Any studies comparing intravenous acetaminophen with a placebo were included in this meta-analysis. Meta-analysis results were collected and analyzed by Stata 12.0. Subgroup analysis was performed according to the general characteristics of the patients. Results In total, the patients from six studies met the inclusion criteria. Our meta-analysis results indicated that compared with a control group, intravenous acetaminophen was associated with reductions in total morphine consumption and visual analogue scale (VAS) score at postoperative day (POD) 3. However, there was no significant difference in morphine consumption at POD 1 or in VAS at POD 1 or POD 2. Moreover, there was no significant difference in the length of hospital stay. Conclusions Based on our results, intravenous acetaminophen in multimodal management has shown better efficacy in pain relief at POD 3 and has morphine-sparing effects. High-quality studies with more patients are needed in the future. |
| first_indexed | 2024-04-11T11:56:50Z |
| format | Article |
| id | doaj.art-bd25895b796d43e78c92b76ebef78e34 |
| institution | Directory Open Access Journal |
| issn | 1749-799X |
| language | English |
| last_indexed | 2024-04-11T11:56:50Z |
| publishDate | 2018-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj.art-bd25895b796d43e78c92b76ebef78e342022-12-22T04:25:07ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2018-10-0113111110.1186/s13018-018-0950-7Efficacy of intravenous acetaminophen in multimodal management for pain relief following total knee arthroplasty: a meta-analysisSong-bo Shi0Xing-bo Wang1Jian-min Song2Shi-fang Guo3Zhi-xin Chen4Yin Wang5Orthopaedics Department, Gansu Provincial HospitalOrthopaedics Department, Gansu Provincial HospitalOrthopaedics Department, Gansu Provincial HospitalOrthopaedics Department, Gansu Provincial HospitalOrthopaedics Department, Gansu Provincial HospitalOrthopaedics Department, Gansu Provincial HospitalAbstract Background The efficacy of intravenous acetaminophen in multimodal pain management in patients undergoing total knee arthroplasty (TKA) is controversial. The purpose of this meta-analysis was to compare the efficacy of intravenous acetaminophen versus placebo in TKA. Methods Randomized controlled trials (RCTs) or retrospective cohort studies (RCSs) concerning related topics were retrieved from PubMed (1996–June 2018), Embase (1980–June 2018), and the Cochrane Library (CENTRAL June 2018). Any studies comparing intravenous acetaminophen with a placebo were included in this meta-analysis. Meta-analysis results were collected and analyzed by Stata 12.0. Subgroup analysis was performed according to the general characteristics of the patients. Results In total, the patients from six studies met the inclusion criteria. Our meta-analysis results indicated that compared with a control group, intravenous acetaminophen was associated with reductions in total morphine consumption and visual analogue scale (VAS) score at postoperative day (POD) 3. However, there was no significant difference in morphine consumption at POD 1 or in VAS at POD 1 or POD 2. Moreover, there was no significant difference in the length of hospital stay. Conclusions Based on our results, intravenous acetaminophen in multimodal management has shown better efficacy in pain relief at POD 3 and has morphine-sparing effects. High-quality studies with more patients are needed in the future.http://link.springer.com/article/10.1186/s13018-018-0950-7AcetaminophenPain controlTotal knee arthroplastyMeta-analysis |
| spellingShingle | Song-bo Shi Xing-bo Wang Jian-min Song Shi-fang Guo Zhi-xin Chen Yin Wang Efficacy of intravenous acetaminophen in multimodal management for pain relief following total knee arthroplasty: a meta-analysis Journal of Orthopaedic Surgery and Research Acetaminophen Pain control Total knee arthroplasty Meta-analysis |
| title | Efficacy of intravenous acetaminophen in multimodal management for pain relief following total knee arthroplasty: a meta-analysis |
| title_full | Efficacy of intravenous acetaminophen in multimodal management for pain relief following total knee arthroplasty: a meta-analysis |
| title_fullStr | Efficacy of intravenous acetaminophen in multimodal management for pain relief following total knee arthroplasty: a meta-analysis |
| title_full_unstemmed | Efficacy of intravenous acetaminophen in multimodal management for pain relief following total knee arthroplasty: a meta-analysis |
| title_short | Efficacy of intravenous acetaminophen in multimodal management for pain relief following total knee arthroplasty: a meta-analysis |
| title_sort | efficacy of intravenous acetaminophen in multimodal management for pain relief following total knee arthroplasty a meta analysis |
| topic | Acetaminophen Pain control Total knee arthroplasty Meta-analysis |
| url | http://link.springer.com/article/10.1186/s13018-018-0950-7 |
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