Therapeutic and immunomodulatory potential of pazopanib in malignant phyllodes tumor

Therapeutic and immunomodulatory potential of pazopanib in malignant phyllodes tumor

Abstract Malignant phyllodes tumors (PT) are rare aggressive fibroepithelial neoplasms with high metastatic potential and lack effective therapy. We established a patient-derived xenograft (PDX) and cell line model (designated MPT-S1) of malignant PT which demonstrated clinical response to pazopanib...

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Bibliographic Details
Main Authors: Dave Yong Xiang Ng, Zhimei Li, Elizabeth Lee, Jessica Sook Ting Kok, Jing Yi Lee, Joanna Koh, Cedric Chuan-Young Ng, Abner Herbert Lim, Wei Liu, Sheng Rong Ng, Kah Suan Lim, Xi Xiao Huang, Jing Han Hong, Peiyong Guan, Yirong Sim, Aye Aye Thike, Nur Diyana Md Nasir, Shang Li, Puay Hoon Tan, Bin Tean Teh, Jason Yongsheng Chan
Format: Article
Language:English
Published: Nature Portfolio 2022-04-01
Series:npj Breast Cancer
Online Access:https://doi.org/10.1038/s41523-022-00413-1

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