Metabolite Profiles of the Relationship between Body Mass Index (BMI) Milestones and Metabolic Risk during Early Adolescence
Early growth is associated with future metabolic risk; however, little is known of the underlying biological pathways. In this prospective study of 249 boys and 227 girls, we sought to identify sex-specific metabolite profiles that mark the relationship between age and magnitude of the infancy body...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-07-01
|
| Series: | Metabolites |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-1989/10/8/316 |
| _version_ | 1797560723390332928 |
|---|---|
| author | Wei Perng Mohammad L. Rahman Izzuddin M. Aris Gregory Michelotti Joanne E. Sordillo Jorge E. Chavarro Emily Oken Marie-France Hivert |
| author_facet | Wei Perng Mohammad L. Rahman Izzuddin M. Aris Gregory Michelotti Joanne E. Sordillo Jorge E. Chavarro Emily Oken Marie-France Hivert |
| author_sort | Wei Perng |
| collection | DOAJ |
| description | Early growth is associated with future metabolic risk; however, little is known of the underlying biological pathways. In this prospective study of 249 boys and 227 girls, we sought to identify sex-specific metabolite profiles that mark the relationship between age and magnitude of the infancy body mass index (BMI) peak, and the childhood BMI rebound with a metabolic syndrome z-score (MetS z-score) during early adolescence (median age 12.8 years). Thirteen consensus metabolite networks were generated between male and female adolescents using weighted correlation network analysis. In girls, none of the networks were related to BMI milestones after false discovery rate (FDR) correction at 5%. In boys, age and/or magnitude of BMI at rebound were associated with three metabolite eigenvector (ME) networks comprising androgen hormones (ME7), lysophospholipids (ME8), and diacylglycerols (ME11) after FDR correction. These networks were also associated with MetS z-score in boys after accounting for age and race/ethnicity: ME7 (1.43 [95% CI: 0.52, 2.34] units higher MetS z-score per 1 unit of ME7), ME8 (−1.01 [95% CI: −1.96, −0.07]), and ME11 (2.88 [95% CI: 2.06, 3.70]). These findings suggest that alterations in sex steroid hormone and lipid metabolism are involved in the relationship of early growth with future metabolic risk in males. |
| first_indexed | 2024-03-10T18:04:32Z |
| format | Article |
| id | doaj.art-bd291ed7e00047ad8eb91f708ce6203d |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-10T18:04:32Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-bd291ed7e00047ad8eb91f708ce6203d2023-11-20T08:39:42ZengMDPI AGMetabolites2218-19892020-07-0110831610.3390/metabo10080316Metabolite Profiles of the Relationship between Body Mass Index (BMI) Milestones and Metabolic Risk during Early AdolescenceWei Perng0Mohammad L. Rahman1Izzuddin M. Aris2Gregory Michelotti3Joanne E. Sordillo4Jorge E. Chavarro5Emily Oken6Marie-France Hivert7Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver Anschutz Medical Campus, Aurora, CO 80045, USADivision of Chronic Disease Research Across the Lifecourse (CoRAL), Department of Population Medicine, Harvard Medical School/Harvard Pilgrim Health Care Institute, Boston, MA 02215, USADivision of Chronic Disease Research Across the Lifecourse (CoRAL), Department of Population Medicine, Harvard Medical School/Harvard Pilgrim Health Care Institute, Boston, MA 02215, USAMetabolon Inc., Durham, NC 27560, USADivision of Chronic Disease Research Across the Lifecourse (CoRAL), Department of Population Medicine, Harvard Medical School/Harvard Pilgrim Health Care Institute, Boston, MA 02215, USADepartment of Nutrition, T. H. Chan Harvard School of Public Health, Boston, MA 02115, USADivision of Chronic Disease Research Across the Lifecourse (CoRAL), Department of Population Medicine, Harvard Medical School/Harvard Pilgrim Health Care Institute, Boston, MA 02215, USADivision of Chronic Disease Research Across the Lifecourse (CoRAL), Department of Population Medicine, Harvard Medical School/Harvard Pilgrim Health Care Institute, Boston, MA 02215, USAEarly growth is associated with future metabolic risk; however, little is known of the underlying biological pathways. In this prospective study of 249 boys and 227 girls, we sought to identify sex-specific metabolite profiles that mark the relationship between age and magnitude of the infancy body mass index (BMI) peak, and the childhood BMI rebound with a metabolic syndrome z-score (MetS z-score) during early adolescence (median age 12.8 years). Thirteen consensus metabolite networks were generated between male and female adolescents using weighted correlation network analysis. In girls, none of the networks were related to BMI milestones after false discovery rate (FDR) correction at 5%. In boys, age and/or magnitude of BMI at rebound were associated with three metabolite eigenvector (ME) networks comprising androgen hormones (ME7), lysophospholipids (ME8), and diacylglycerols (ME11) after FDR correction. These networks were also associated with MetS z-score in boys after accounting for age and race/ethnicity: ME7 (1.43 [95% CI: 0.52, 2.34] units higher MetS z-score per 1 unit of ME7), ME8 (−1.01 [95% CI: −1.96, −0.07]), and ME11 (2.88 [95% CI: 2.06, 3.70]). These findings suggest that alterations in sex steroid hormone and lipid metabolism are involved in the relationship of early growth with future metabolic risk in males.https://www.mdpi.com/2218-1989/10/8/316metabolitesBMI milestonesgrowthmetabolic riskadolescents |
| spellingShingle | Wei Perng Mohammad L. Rahman Izzuddin M. Aris Gregory Michelotti Joanne E. Sordillo Jorge E. Chavarro Emily Oken Marie-France Hivert Metabolite Profiles of the Relationship between Body Mass Index (BMI) Milestones and Metabolic Risk during Early Adolescence Metabolites metabolites BMI milestones growth metabolic risk adolescents |
| title | Metabolite Profiles of the Relationship between Body Mass Index (BMI) Milestones and Metabolic Risk during Early Adolescence |
| title_full | Metabolite Profiles of the Relationship between Body Mass Index (BMI) Milestones and Metabolic Risk during Early Adolescence |
| title_fullStr | Metabolite Profiles of the Relationship between Body Mass Index (BMI) Milestones and Metabolic Risk during Early Adolescence |
| title_full_unstemmed | Metabolite Profiles of the Relationship between Body Mass Index (BMI) Milestones and Metabolic Risk during Early Adolescence |
| title_short | Metabolite Profiles of the Relationship between Body Mass Index (BMI) Milestones and Metabolic Risk during Early Adolescence |
| title_sort | metabolite profiles of the relationship between body mass index bmi milestones and metabolic risk during early adolescence |
| topic | metabolites BMI milestones growth metabolic risk adolescents |
| url | https://www.mdpi.com/2218-1989/10/8/316 |
| work_keys_str_mv | AT weiperng metaboliteprofilesoftherelationshipbetweenbodymassindexbmimilestonesandmetabolicriskduringearlyadolescence AT mohammadlrahman metaboliteprofilesoftherelationshipbetweenbodymassindexbmimilestonesandmetabolicriskduringearlyadolescence AT izzuddinmaris metaboliteprofilesoftherelationshipbetweenbodymassindexbmimilestonesandmetabolicriskduringearlyadolescence AT gregorymichelotti metaboliteprofilesoftherelationshipbetweenbodymassindexbmimilestonesandmetabolicriskduringearlyadolescence AT joanneesordillo metaboliteprofilesoftherelationshipbetweenbodymassindexbmimilestonesandmetabolicriskduringearlyadolescence AT jorgeechavarro metaboliteprofilesoftherelationshipbetweenbodymassindexbmimilestonesandmetabolicriskduringearlyadolescence AT emilyoken metaboliteprofilesoftherelationshipbetweenbodymassindexbmimilestonesandmetabolicriskduringearlyadolescence AT mariefrancehivert metaboliteprofilesoftherelationshipbetweenbodymassindexbmimilestonesandmetabolicriskduringearlyadolescence |