Nasal delivery of H5N1 avian influenza vaccine formulated with GenJet™ or in vivo-jetPEI® induces enhanced serological, cellular and protective immune responses

Nasal delivery of H5N1 avian influenza vaccine formulated with GenJet™ or in vivo-jetPEI® induces enhanced serological, cellular and protective immune responses

Avian influenza virus infection is a serious public health threat and preventive vaccination is the most cost-effective public health intervention strategy. Unfortunately, currently available unadjuvanted avian influenza vaccines are poorly immunogenic and alternative vaccine formulations and delive...

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Bibliographic Details
Main Authors: Weiping Cao, Margarita Mishina, Samuel Amoah, Wadzanai P. Mboko, Caitlin Bohannon, James McCoy, Suresh K. Mittal, Shivaprakash Gangappa, Suryaprakash Sambhara
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:Drug Delivery
Subjects:
cationic polymers
h5n1 vaccine
adaptive immunity
protective immunity
mouse model
influenza
Online Access:http://dx.doi.org/10.1080/10717544.2018.1450909

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