Pathological convergence of APP and SNCA deficiency in hippocampal degeneration of young rats

Pathological convergence of APP and SNCA deficiency in hippocampal degeneration of young rats

Abstract The common pathogenesis of Alzheimer’s disease (AD) and Parkinson’s disease (PD) has been supported by biochemical, genetic and molecular evidence. Mitochondrial dysfunction is considered to be the common pathology in early AD and PD. The physiological regulation of APP and α-synuclein on m...

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Bibliographic Details
Main Authors: Yajie Wang, Zhikang Miao, Chang Xu, Ying Cai, Yuting Yang, Yue Hu, Mengna Zhao, Yue Shao, Zhiqiang Li, Jincao Chen, Shi Chen, Lianrong Wang
Format: Article
Language:English
Published: Nature Publishing Group 2023-05-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-05846-5

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