Uric acid disrupts hypochlorous acid production and the bactericidal activity of HL-60 cells

Uric acid disrupts hypochlorous acid production and the bactericidal activity of HL-60 cells

Uric acid is the end product of purine metabolism in humans and is an alternative physiological substrate for myeloperoxidase. Oxidation of uric acid by this enzyme generates uric acid free radical and urate hydroperoxide, a strong oxidant and potentially bactericide agent. In this study, we investi...

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Bibliographic Details
Main Authors:	Larissa A.C. Carvalho, João P.P.B. Lopes, Gilberto H. Kaihami, Railmara P. Silva, Alexandre Bruni-Cardoso, Regina L. Baldini, Flavia C. Meotti
Format:	Article
Language:	English
Published:	Elsevier 2018-06-01
Series:	Redox Biology
Online Access:	http://www.sciencedirect.com/science/article/pii/S221323171830034X

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