PSAT1 positively regulates the osteogenic lineage differentiation of periodontal ligament stem cells through the ATF4/PSAT1/Akt/GSK3β/β-catenin axis

PSAT1 positively regulates the osteogenic lineage differentiation of periodontal ligament stem cells through the ATF4/PSAT1/Akt/GSK3β/β-catenin axis

Abstract Background Periodontal ligament stem cells (PDLSCs) are important seed cells for tissue engineering to realize the regeneration of alveolar bone. Understanding the gene regulatory mechanisms of osteogenic lineage differentiation in PDLSCs will facilitate PDLSC-based bone regeneration. Howev...

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Bibliographic Details
Main Authors:	Linglu Jia, Dongfang Li, Ya-Nan Wang, Dongjiao Zhang, Xin Xu
Format:	Article
Language:	English
Published:	BMC 2023-02-01
Series:	Journal of Translational Medicine
Subjects:	PSAT1 Periodontal ligament stem cells Osteogenic differentiation Microarray assay
Online Access:	https://doi.org/10.1186/s12967-022-03775-z

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