Chlorproguanil-dapsone-artesunate versus artemether-lumefantrine: a randomized, double-blind phase III trial in African children and adolescents with uncomplicated Plasmodium falciparum malaria.

Chlorproguanil-dapsone-artesunate versus artemether-lumefantrine: a randomized, double-blind phase III trial in African children and adolescents with uncomplicated Plasmodium falciparum malaria.

BACKGROUND:Chlorproguanil-dapsone-artesunate (CDA) was developed as an affordable, simple, fixed-dose artemisinin-based combination therapy for use in Africa. This trial was a randomized parallel-group, double-blind, double-dummy study to compare CDA and artemether-lumefantrine (AL) efficacy in unco...

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Main Authors: Zul Premji, Rich E Umeh, Seth Owusu-Agyei, Fabian Esamai, Emmanuel U Ezedinachi, Stephen Oguche, Steffen Borrmann, Akintunde Sowunmi, Stephan Duparc, Paula L Kirby, Allan Pamba, Lynda Kellam, Robert Guiguemdé, Brian Greenwood, Stephen A Ward, Peter A Winstanley
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-08-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2724683?pdf=render

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