| Summary: | In the present work, the facile eco-friendly synthesis and evaluation of the anti-tumor activity of Ni(OH)<sub>2</sub>@Mn<sub>3</sub>O<sub>4</sub> nanocomposite were carried out. The synthesis of Ni(OH)<sub>2</sub>@Mn<sub>3</sub>O<sub>4</sub> nanocomposite from chia-seed extract was mediated by sonication. The obtained materials were characterized by different spectroscopic techniques such as transmission electron microscopy (TEM), scanning electron microscope (SEM), energy-dispersive X-ray spectroscopy (EDS), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), ultraviolet-visible (UV-Vis), and Fourier transform infrared (FT-IR) spectroscopies. The results of XRD, SEM, EDS, TEM, FT-IR, and UV-Vis analysis indicate the successful manufacturing of a crystalline, cactus-type Ni(OH)<sub>2</sub>@Mn<sub>3</sub>O<sub>4</sub> nanocomposite of 10.10 nm average particle size. XPS analysis confirms that the synthesized materials consist mainly of Ni<sup>2+</sup>, Mn<sup>2+</sup>, and Mn<sup>3+</sup>. The antitumor activity of the nanocomposite was tested against a breast cancer (MCF-7) cell line. The results showed Ni(OH)<sub>2</sub>@Mn<sub>3</sub>O<sub>4</sub> nanocomposite possesses insignificant cytotoxicity. The cell-death percentage was 34% at a 100 ppm concentration of Ni(OH)<sub>2</sub>@Mn<sub>3</sub>O<sub>4</sub> nanocomposite. The obtained results imply that the synthesized nanocomposite could be suitable and safe for drug delivery and water treatment.
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