Facile Green Synthesis of Ni(OH)<sub>2</sub>@Mn<sub>3</sub>O<sub>4</sub> Cactus-Type Nanocomposite: Characterization and Cytotoxicity Properties

Facile Green Synthesis of Ni(OH)<sub>2</sub>@Mn<sub>3</sub>O<sub>4</sub> Cactus-Type Nanocomposite: Characterization and Cytotoxicity Properties

In the present work, the facile eco-friendly synthesis and evaluation of the anti-tumor activity of Ni(OH)<sub>2</sub>@Mn<sub>3</sub>O<sub>4</sub> nanocomposite were carried out. The synthesis of Ni(OH)<sub>2</sub>@Mn<sub>3</sub>O<sub>...

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Main Authors: Amel Taha, Hanaa A. Hassanin
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Molecules
Subjects:
Ni(OH)<sub>2</sub>@Mn<sub>3</sub>O<sub>4</sub>
nanocomposite
antitumor
chia seeds
MCF-7
Online Access:https://www.mdpi.com/1420-3049/27/24/8703
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author Amel Taha
Hanaa A. Hassanin
author_facet Amel Taha
Hanaa A. Hassanin
author_sort Amel Taha
collection DOAJ
description In the present work, the facile eco-friendly synthesis and evaluation of the anti-tumor activity of Ni(OH)<sub>2</sub>@Mn<sub>3</sub>O<sub>4</sub> nanocomposite were carried out. The synthesis of Ni(OH)<sub>2</sub>@Mn<sub>3</sub>O<sub>4</sub> nanocomposite from chia-seed extract was mediated by sonication. The obtained materials were characterized by different spectroscopic techniques such as transmission electron microscopy (TEM), scanning electron microscope (SEM), energy-dispersive X-ray spectroscopy (EDS), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), ultraviolet-visible (UV-Vis), and Fourier transform infrared (FT-IR) spectroscopies. The results of XRD, SEM, EDS, TEM, FT-IR, and UV-Vis analysis indicate the successful manufacturing of a crystalline, cactus-type Ni(OH)<sub>2</sub>@Mn<sub>3</sub>O<sub>4</sub> nanocomposite of 10.10 nm average particle size. XPS analysis confirms that the synthesized materials consist mainly of Ni<sup>2+</sup>, Mn<sup>2+</sup>, and Mn<sup>3+</sup>. The antitumor activity of the nanocomposite was tested against a breast cancer (MCF-7) cell line. The results showed Ni(OH)<sub>2</sub>@Mn<sub>3</sub>O<sub>4</sub> nanocomposite possesses insignificant cytotoxicity. The cell-death percentage was 34% at a 100 ppm concentration of Ni(OH)<sub>2</sub>@Mn<sub>3</sub>O<sub>4</sub> nanocomposite. The obtained results imply that the synthesized nanocomposite could be suitable and safe for drug delivery and water treatment.
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spelling doaj.art-bd331e83f4544dd8aee5f457a86cad372023-11-24T16:56:00ZengMDPI AGMolecules1420-30492022-12-012724870310.3390/molecules27248703Facile Green Synthesis of Ni(OH)<sub>2</sub>@Mn<sub>3</sub>O<sub>4</sub> Cactus-Type Nanocomposite: Characterization and Cytotoxicity PropertiesAmel Taha0Hanaa A. Hassanin1Department of Chemistry, College of Science, King Faisal University, P.O. Box 400, Al-Ahsa 31982, Saudi ArabiaDepartment of Chemistry, College of Science, King Faisal University, P.O. Box 400, Al-Ahsa 31982, Saudi ArabiaIn the present work, the facile eco-friendly synthesis and evaluation of the anti-tumor activity of Ni(OH)<sub>2</sub>@Mn<sub>3</sub>O<sub>4</sub> nanocomposite were carried out. The synthesis of Ni(OH)<sub>2</sub>@Mn<sub>3</sub>O<sub>4</sub> nanocomposite from chia-seed extract was mediated by sonication. The obtained materials were characterized by different spectroscopic techniques such as transmission electron microscopy (TEM), scanning electron microscope (SEM), energy-dispersive X-ray spectroscopy (EDS), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), ultraviolet-visible (UV-Vis), and Fourier transform infrared (FT-IR) spectroscopies. The results of XRD, SEM, EDS, TEM, FT-IR, and UV-Vis analysis indicate the successful manufacturing of a crystalline, cactus-type Ni(OH)<sub>2</sub>@Mn<sub>3</sub>O<sub>4</sub> nanocomposite of 10.10 nm average particle size. XPS analysis confirms that the synthesized materials consist mainly of Ni<sup>2+</sup>, Mn<sup>2+</sup>, and Mn<sup>3+</sup>. The antitumor activity of the nanocomposite was tested against a breast cancer (MCF-7) cell line. The results showed Ni(OH)<sub>2</sub>@Mn<sub>3</sub>O<sub>4</sub> nanocomposite possesses insignificant cytotoxicity. The cell-death percentage was 34% at a 100 ppm concentration of Ni(OH)<sub>2</sub>@Mn<sub>3</sub>O<sub>4</sub> nanocomposite. The obtained results imply that the synthesized nanocomposite could be suitable and safe for drug delivery and water treatment.https://www.mdpi.com/1420-3049/27/24/8703Ni(OH)<sub>2</sub>@Mn<sub>3</sub>O<sub>4</sub>nanocompositeantitumorchia seedsMCF-7
spellingShingle Amel Taha
Hanaa A. Hassanin
Facile Green Synthesis of Ni(OH)<sub>2</sub>@Mn<sub>3</sub>O<sub>4</sub> Cactus-Type Nanocomposite: Characterization and Cytotoxicity Properties
Molecules
Ni(OH)<sub>2</sub>@Mn<sub>3</sub>O<sub>4</sub>
nanocomposite
antitumor
chia seeds
MCF-7
title Facile Green Synthesis of Ni(OH)<sub>2</sub>@Mn<sub>3</sub>O<sub>4</sub> Cactus-Type Nanocomposite: Characterization and Cytotoxicity Properties
title_full Facile Green Synthesis of Ni(OH)<sub>2</sub>@Mn<sub>3</sub>O<sub>4</sub> Cactus-Type Nanocomposite: Characterization and Cytotoxicity Properties
title_fullStr Facile Green Synthesis of Ni(OH)<sub>2</sub>@Mn<sub>3</sub>O<sub>4</sub> Cactus-Type Nanocomposite: Characterization and Cytotoxicity Properties
title_full_unstemmed Facile Green Synthesis of Ni(OH)<sub>2</sub>@Mn<sub>3</sub>O<sub>4</sub> Cactus-Type Nanocomposite: Characterization and Cytotoxicity Properties
title_short Facile Green Synthesis of Ni(OH)<sub>2</sub>@Mn<sub>3</sub>O<sub>4</sub> Cactus-Type Nanocomposite: Characterization and Cytotoxicity Properties
title_sort facile green synthesis of ni oh sub 2 sub mn sub 3 sub o sub 4 sub cactus type nanocomposite characterization and cytotoxicity properties
topic Ni(OH)<sub>2</sub>@Mn<sub>3</sub>O<sub>4</sub>
nanocomposite
antitumor
chia seeds
MCF-7
url https://www.mdpi.com/1420-3049/27/24/8703
work_keys_str_mv AT ameltaha facilegreensynthesisofniohsub2submnsub3subosub4subcactustypenanocompositecharacterizationandcytotoxicityproperties
AT hanaaahassanin facilegreensynthesisofniohsub2submnsub3subosub4subcactustypenanocompositecharacterizationandcytotoxicityproperties

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