Acute myeloid leukemia with myelodysplasia-related changes and blasts of the mixed T/myeloid phenotype: a case report
A rare but clinically important diagnostic dilemma arises when cases meet the criteria for both acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) and mixed phenotype acute leukemia, especially those that evolve from myelodysplastic syndrome. We describe a 56-year-old male patient...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
SAGE Publishing
2022-09-01
|
Series: | Journal of International Medical Research |
Online Access: | https://doi.org/10.1177/03000605221122741 |
_version_ | 1798031435775344640 |
---|---|
author | Xian-Fu Sheng Li-Li Hong Fei-Yan Huang Hai-Feng Zhuang |
author_facet | Xian-Fu Sheng Li-Li Hong Fei-Yan Huang Hai-Feng Zhuang |
author_sort | Xian-Fu Sheng |
collection | DOAJ |
description | A rare but clinically important diagnostic dilemma arises when cases meet the criteria for both acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) and mixed phenotype acute leukemia, especially those that evolve from myelodysplastic syndrome. We describe a 56-year-old male patient who presented with cytopenias and was initially diagnosed with myelodysplastic syndrome with single lineage dysplasia. Nearly 1 year later, this patient progressed to acute leukemia, and his blast cells simultaneously expressed T-lymphoid and myeloid antigens. Cytogenetic analysis showed a 20q deletion, and next-generation sequencing showed mutations of ASXL1, NRAS, PHF6, RUNX1, TP53, and PIGA. He was diagnosed with AML-MRC with blasts of the mixed T/myeloid phenotype according to the latest World Health Organization guidelines. In accordance with the treatment principles of AML-MRC, we chose an AML-like regimen for four cycles, but the patient did not achieve remission. Finally, we adhered to the treatment principles of mixed phenotype acute leukemia, and he achieved remission after a course of ALL-like regimen chemotherapy. |
first_indexed | 2024-04-11T19:57:22Z |
format | Article |
id | doaj.art-bd332a02048143659e3705323fdbc514 |
institution | Directory Open Access Journal |
issn | 1473-2300 |
language | English |
last_indexed | 2024-04-11T19:57:22Z |
publishDate | 2022-09-01 |
publisher | SAGE Publishing |
record_format | Article |
series | Journal of International Medical Research |
spelling | doaj.art-bd332a02048143659e3705323fdbc5142022-12-22T04:05:59ZengSAGE PublishingJournal of International Medical Research1473-23002022-09-015010.1177/03000605221122741Acute myeloid leukemia with myelodysplasia-related changes and blasts of the mixed T/myeloid phenotype: a case reportXian-Fu ShengLi-Li HongFei-Yan HuangHai-Feng ZhuangA rare but clinically important diagnostic dilemma arises when cases meet the criteria for both acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) and mixed phenotype acute leukemia, especially those that evolve from myelodysplastic syndrome. We describe a 56-year-old male patient who presented with cytopenias and was initially diagnosed with myelodysplastic syndrome with single lineage dysplasia. Nearly 1 year later, this patient progressed to acute leukemia, and his blast cells simultaneously expressed T-lymphoid and myeloid antigens. Cytogenetic analysis showed a 20q deletion, and next-generation sequencing showed mutations of ASXL1, NRAS, PHF6, RUNX1, TP53, and PIGA. He was diagnosed with AML-MRC with blasts of the mixed T/myeloid phenotype according to the latest World Health Organization guidelines. In accordance with the treatment principles of AML-MRC, we chose an AML-like regimen for four cycles, but the patient did not achieve remission. Finally, we adhered to the treatment principles of mixed phenotype acute leukemia, and he achieved remission after a course of ALL-like regimen chemotherapy.https://doi.org/10.1177/03000605221122741 |
spellingShingle | Xian-Fu Sheng Li-Li Hong Fei-Yan Huang Hai-Feng Zhuang Acute myeloid leukemia with myelodysplasia-related changes and blasts of the mixed T/myeloid phenotype: a case report Journal of International Medical Research |
title | Acute myeloid leukemia with myelodysplasia-related changes and blasts of the mixed T/myeloid phenotype: a case report |
title_full | Acute myeloid leukemia with myelodysplasia-related changes and blasts of the mixed T/myeloid phenotype: a case report |
title_fullStr | Acute myeloid leukemia with myelodysplasia-related changes and blasts of the mixed T/myeloid phenotype: a case report |
title_full_unstemmed | Acute myeloid leukemia with myelodysplasia-related changes and blasts of the mixed T/myeloid phenotype: a case report |
title_short | Acute myeloid leukemia with myelodysplasia-related changes and blasts of the mixed T/myeloid phenotype: a case report |
title_sort | acute myeloid leukemia with myelodysplasia related changes and blasts of the mixed t myeloid phenotype a case report |
url | https://doi.org/10.1177/03000605221122741 |
work_keys_str_mv | AT xianfusheng acutemyeloidleukemiawithmyelodysplasiarelatedchangesandblastsofthemixedtmyeloidphenotypeacasereport AT lilihong acutemyeloidleukemiawithmyelodysplasiarelatedchangesandblastsofthemixedtmyeloidphenotypeacasereport AT feiyanhuang acutemyeloidleukemiawithmyelodysplasiarelatedchangesandblastsofthemixedtmyeloidphenotypeacasereport AT haifengzhuang acutemyeloidleukemiawithmyelodysplasiarelatedchangesandblastsofthemixedtmyeloidphenotypeacasereport |