MicroRNA engineered umbilical cord stem cell-derived exosomes direct tendon regeneration by mTOR signaling

MicroRNA engineered umbilical cord stem cell-derived exosomes direct tendon regeneration by mTOR signaling

Abstract Background Exosomes are extracellular vesicles of nano-structures and represent an emerging nano-scale acellular therapy in recent years. Tendon regeneration is a sophisticated process in the field of microsurgery due to its poor natural healing ability. To date, no successful long-term sol...

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Bibliographic Details
Main Authors: Zhixiao Yao, Juehong Li, Hao Xiong, Haomin Cui, Jiexin Ning, Shikun Wang, Xingyu Ouyang, Yun Qian, Cunyi Fan
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Journal of Nanobiotechnology
Subjects:
Tendon repair
Human umbilical cord mesenchymal stem cell
Exosome
PTEN
mTOR
miR-29a-3p
Online Access:https://doi.org/10.1186/s12951-021-00906-4

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