Dynamic MAIT cell response with progressively enhanced innateness during acute HIV-1 infection
Here, using longitudinal pre- and post-infection samples from the RV217 Early Capture HIV Cohort Study, the authors show that mucosa-associated invariant T (MAIT) cells become activated and expand during the early acute phase of HIV infection, with subsequent reprogramming towards innate-like functi...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-01-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-13975-9 |
| _version_ | 1818400486526550016 |
|---|---|
| author | Kerri G. Lal Dohoon Kim Margaret C. Costanzo Matthew Creegan Edwin Leeansyah Joana Dias Dominic Paquin-Proulx Leigh Anne Eller Alexandra Schuetz Yuwadee Phuang-ngern Shelly J. Krebs Bonnie M. Slike Hannah Kibuuka Lucas Maganga Sorachai Nitayaphan Josphat Kosgei Carlo Sacdalan Jintanat Ananworanich Diane L. Bolton Nelson L. Michael Barbara L. Shacklett Merlin L. Robb Michael A. Eller Johan K. Sandberg |
| author_facet | Kerri G. Lal Dohoon Kim Margaret C. Costanzo Matthew Creegan Edwin Leeansyah Joana Dias Dominic Paquin-Proulx Leigh Anne Eller Alexandra Schuetz Yuwadee Phuang-ngern Shelly J. Krebs Bonnie M. Slike Hannah Kibuuka Lucas Maganga Sorachai Nitayaphan Josphat Kosgei Carlo Sacdalan Jintanat Ananworanich Diane L. Bolton Nelson L. Michael Barbara L. Shacklett Merlin L. Robb Michael A. Eller Johan K. Sandberg |
| author_sort | Kerri G. Lal |
| collection | DOAJ |
| description | Here, using longitudinal pre- and post-infection samples from the RV217 Early Capture HIV Cohort Study, the authors show that mucosa-associated invariant T (MAIT) cells become activated and expand during the early acute phase of HIV infection, with subsequent reprogramming towards innate-like functionality. |
| first_indexed | 2024-12-14T07:37:20Z |
| format | Article |
| id | doaj.art-bd358f6fc61c41148394e312726032c9 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T07:37:20Z |
| publishDate | 2020-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-bd358f6fc61c41148394e312726032c92022-12-21T23:11:09ZengNature PortfolioNature Communications2041-17232020-01-0111111310.1038/s41467-019-13975-9Dynamic MAIT cell response with progressively enhanced innateness during acute HIV-1 infectionKerri G. Lal0Dohoon Kim1Margaret C. Costanzo2Matthew Creegan3Edwin Leeansyah4Joana Dias5Dominic Paquin-Proulx6Leigh Anne Eller7Alexandra Schuetz8Yuwadee Phuang-ngern9Shelly J. Krebs10Bonnie M. Slike11Hannah Kibuuka12Lucas Maganga13Sorachai Nitayaphan14Josphat Kosgei15Carlo Sacdalan16Jintanat Ananworanich17Diane L. Bolton18Nelson L. Michael19Barbara L. Shacklett20Merlin L. Robb21Michael A. Eller22Johan K. Sandberg23U.S. Military HIV Research Program, Walter Reed Army Institute of ResearchU.S. Military HIV Research Program, Walter Reed Army Institute of ResearchU.S. Military HIV Research Program, Walter Reed Army Institute of ResearchU.S. Military HIV Research Program, Walter Reed Army Institute of ResearchCenter for Infectious Medicine, Department of Medicine, Karolinska InstitutetCenter for Infectious Medicine, Department of Medicine, Karolinska InstitutetU.S. Military HIV Research Program, Walter Reed Army Institute of ResearchU.S. Military HIV Research Program, Walter Reed Army Institute of ResearchU.S. Military HIV Research Program, Walter Reed Army Institute of ResearchDepartment of Retrovirology, Armed Forces Research Institute of Medical SciencesU.S. Military HIV Research Program, Walter Reed Army Institute of ResearchU.S. Military HIV Research Program, Walter Reed Army Institute of ResearchMakerere University Walter Reed ProjectNational Institute for Medical Research-Mbeya Medical Research CenterRoyal Thai Army Component, Armed Forces Research Institute of Medical SciencesKenya Medical Research Institute/U.S. Army Medical Research Directorate-Africa/KenyaSEARCH, The Thai Red Cross AIDS Research CentreU.S. Military HIV Research Program, Walter Reed Army Institute of ResearchU.S. Military HIV Research Program, Walter Reed Army Institute of ResearchU.S. Military HIV Research Program, Walter Reed Army Institute of ResearchDepartment of Medical Microbiology and Immunology, School of Medicine, University of California DavisU.S. Military HIV Research Program, Walter Reed Army Institute of ResearchU.S. Military HIV Research Program, Walter Reed Army Institute of ResearchCenter for Infectious Medicine, Department of Medicine, Karolinska InstitutetHere, using longitudinal pre- and post-infection samples from the RV217 Early Capture HIV Cohort Study, the authors show that mucosa-associated invariant T (MAIT) cells become activated and expand during the early acute phase of HIV infection, with subsequent reprogramming towards innate-like functionality.https://doi.org/10.1038/s41467-019-13975-9 |
| spellingShingle | Kerri G. Lal Dohoon Kim Margaret C. Costanzo Matthew Creegan Edwin Leeansyah Joana Dias Dominic Paquin-Proulx Leigh Anne Eller Alexandra Schuetz Yuwadee Phuang-ngern Shelly J. Krebs Bonnie M. Slike Hannah Kibuuka Lucas Maganga Sorachai Nitayaphan Josphat Kosgei Carlo Sacdalan Jintanat Ananworanich Diane L. Bolton Nelson L. Michael Barbara L. Shacklett Merlin L. Robb Michael A. Eller Johan K. Sandberg Dynamic MAIT cell response with progressively enhanced innateness during acute HIV-1 infection Nature Communications |
| title | Dynamic MAIT cell response with progressively enhanced innateness during acute HIV-1 infection |
| title_full | Dynamic MAIT cell response with progressively enhanced innateness during acute HIV-1 infection |
| title_fullStr | Dynamic MAIT cell response with progressively enhanced innateness during acute HIV-1 infection |
| title_full_unstemmed | Dynamic MAIT cell response with progressively enhanced innateness during acute HIV-1 infection |
| title_short | Dynamic MAIT cell response with progressively enhanced innateness during acute HIV-1 infection |
| title_sort | dynamic mait cell response with progressively enhanced innateness during acute hiv 1 infection |
| url | https://doi.org/10.1038/s41467-019-13975-9 |
| work_keys_str_mv | AT kerriglal dynamicmaitcellresponsewithprogressivelyenhancedinnatenessduringacutehiv1infection AT dohoonkim dynamicmaitcellresponsewithprogressivelyenhancedinnatenessduringacutehiv1infection AT margaretccostanzo dynamicmaitcellresponsewithprogressivelyenhancedinnatenessduringacutehiv1infection AT matthewcreegan dynamicmaitcellresponsewithprogressivelyenhancedinnatenessduringacutehiv1infection AT edwinleeansyah dynamicmaitcellresponsewithprogressivelyenhancedinnatenessduringacutehiv1infection AT joanadias dynamicmaitcellresponsewithprogressivelyenhancedinnatenessduringacutehiv1infection AT dominicpaquinproulx dynamicmaitcellresponsewithprogressivelyenhancedinnatenessduringacutehiv1infection AT leighanneeller dynamicmaitcellresponsewithprogressivelyenhancedinnatenessduringacutehiv1infection AT alexandraschuetz dynamicmaitcellresponsewithprogressivelyenhancedinnatenessduringacutehiv1infection AT yuwadeephuangngern dynamicmaitcellresponsewithprogressivelyenhancedinnatenessduringacutehiv1infection AT shellyjkrebs dynamicmaitcellresponsewithprogressivelyenhancedinnatenessduringacutehiv1infection AT bonniemslike dynamicmaitcellresponsewithprogressivelyenhancedinnatenessduringacutehiv1infection AT hannahkibuuka dynamicmaitcellresponsewithprogressivelyenhancedinnatenessduringacutehiv1infection AT lucasmaganga dynamicmaitcellresponsewithprogressivelyenhancedinnatenessduringacutehiv1infection AT sorachainitayaphan dynamicmaitcellresponsewithprogressivelyenhancedinnatenessduringacutehiv1infection AT josphatkosgei dynamicmaitcellresponsewithprogressivelyenhancedinnatenessduringacutehiv1infection AT carlosacdalan dynamicmaitcellresponsewithprogressivelyenhancedinnatenessduringacutehiv1infection AT jintanatananworanich dynamicmaitcellresponsewithprogressivelyenhancedinnatenessduringacutehiv1infection AT dianelbolton dynamicmaitcellresponsewithprogressivelyenhancedinnatenessduringacutehiv1infection AT nelsonlmichael dynamicmaitcellresponsewithprogressivelyenhancedinnatenessduringacutehiv1infection AT barbaralshacklett dynamicmaitcellresponsewithprogressivelyenhancedinnatenessduringacutehiv1infection AT merlinlrobb dynamicmaitcellresponsewithprogressivelyenhancedinnatenessduringacutehiv1infection AT michaelaeller dynamicmaitcellresponsewithprogressivelyenhancedinnatenessduringacutehiv1infection AT johanksandberg dynamicmaitcellresponsewithprogressivelyenhancedinnatenessduringacutehiv1infection |