Interplay among differential exposure to Mycobacterium leprae and TLR4 polymorphism impacts the immune response in household contacts of leprosy patients

Interplay among differential exposure to Mycobacterium leprae and TLR4 polymorphism impacts the immune response in household contacts of leprosy patients

IntroductionThe aim of the present study was to investigate the association between the single nucleotide polymorphism (SNP) rs1927914 A/G in TLR4 gene and the immunological profile of household contacts (HHC) of leprosy patients. Leprosy classification is usually complex and requires the assessment...

Full description

Bibliographic Details
Main Authors: Eloisa Helena Medeiros Cunha, Pedro Henrique Ferreira Marçal, Rafael Silva Gama, Lorena Bruna Pereira de Oliveira, Roberta Olmo Pinheiro, Euzenir Nunes Sarno, Joaquim Pedro Brito-de-Sousa, Márcio Luís Moreira de Souza, Jessica Kathleen Fairley, Thaisa Netto Souza Valente, Cibele Velloso-Rodrigues, Olindo Assis Martins-Filho, Dirce Ribeiro de Oliveira, Lucia Alves de Oliveira Fraga
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Immunology
Subjects:
leprosy
chemokines and cytokines
immunological factors
genetic factors
TLR4 gene
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1130137/full

Similar Items

Similar Items