The association of vitamin D status with oxidative stress biomarkers and matrix metalloproteinases in patients with knee osteoarthritis
ObjectiveThe association of vitamin D status with osteoarthritis (OA) has been demonstrated previously. The current study was performed to examine the association of vitamin D status with oxidative stress markers and matrix metalloproteinases (MMPs) in patients with knee OA.MethodsThis case–control...
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1101516/full |
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| author | Farshad Amirkhizi Seyed Mojtaba Ghoreishy Emma Baker Soudabeh Hamedi-Shahraki Somayyeh Asghari |
| author_facet | Farshad Amirkhizi Seyed Mojtaba Ghoreishy Emma Baker Soudabeh Hamedi-Shahraki Somayyeh Asghari |
| author_sort | Farshad Amirkhizi |
| collection | DOAJ |
| description | ObjectiveThe association of vitamin D status with osteoarthritis (OA) has been demonstrated previously. The current study was performed to examine the association of vitamin D status with oxidative stress markers and matrix metalloproteinases (MMPs) in patients with knee OA.MethodsThis case–control study was conducted on 124 subjects with mild to moderate knee OA and 65 healthy controls. Demographic data was collected from all participants at baseline. Serum levels of vitamin D as well as markers of oxidative stress including malondialdehyde (MDA), total oxidant status (TOS), superoxide dismutase (SOD), oxidative stress index (OSI), paraoxonase-1 (PON-1), glutathione peroxidase (GPX), catalase (CAT), and total antioxidant capacity (TAC) were evaluated for each participant. Furthermore, serum concentrations of MMP-1, MMP-3, MMP-13, and cartilage oligomeric matrix protein (COMP) were measured.ResultsThe results of the present study indicated that individuals with vitamin D insufficiency had higher levels of MDA, TOS, SOD, and OSI as well as lower levels of PON-1 and TAC. Based on the linear regression analysis, serum vitamin D levels were inversely correlated with MDA, TOS, SOD, OSI, MMP-1, and MMP-13 and positively associated with TAC levels (p < 0.0001). Patients with sufficient vitamin D levels had lower MMP-1 and MMP-13 levels compared to patients with vitamin D insufficiency (p < 0.001 and p < 0.001, respectively).ConclusionFindings from this study showed a strong association between vitamin D deficiency and increased oxidative stress and MMPs activity in patients with knee OA. |
| first_indexed | 2024-04-10T16:42:30Z |
| format | Article |
| id | doaj.art-bd377bc774964373926ebca485495bbd |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-10T16:42:30Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-bd377bc774964373926ebca485495bbd2023-02-08T05:53:38ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-02-011010.3389/fnut.2023.11015161101516The association of vitamin D status with oxidative stress biomarkers and matrix metalloproteinases in patients with knee osteoarthritisFarshad Amirkhizi0Seyed Mojtaba Ghoreishy1Emma Baker2Soudabeh Hamedi-Shahraki3Somayyeh Asghari4Department of Nutrition, Faculty of Public Health, Zabol University of Medical Sciences, Zabol, IranDepartment of Clinical Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, IranCabrini Research, Malvern, VIC, AustraliaDepartment of Epidemiology and Biostatistics, Faculty of Public Health, Zabol University of Medical Sciences, Zabol, IranDepartment of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, IranObjectiveThe association of vitamin D status with osteoarthritis (OA) has been demonstrated previously. The current study was performed to examine the association of vitamin D status with oxidative stress markers and matrix metalloproteinases (MMPs) in patients with knee OA.MethodsThis case–control study was conducted on 124 subjects with mild to moderate knee OA and 65 healthy controls. Demographic data was collected from all participants at baseline. Serum levels of vitamin D as well as markers of oxidative stress including malondialdehyde (MDA), total oxidant status (TOS), superoxide dismutase (SOD), oxidative stress index (OSI), paraoxonase-1 (PON-1), glutathione peroxidase (GPX), catalase (CAT), and total antioxidant capacity (TAC) were evaluated for each participant. Furthermore, serum concentrations of MMP-1, MMP-3, MMP-13, and cartilage oligomeric matrix protein (COMP) were measured.ResultsThe results of the present study indicated that individuals with vitamin D insufficiency had higher levels of MDA, TOS, SOD, and OSI as well as lower levels of PON-1 and TAC. Based on the linear regression analysis, serum vitamin D levels were inversely correlated with MDA, TOS, SOD, OSI, MMP-1, and MMP-13 and positively associated with TAC levels (p < 0.0001). Patients with sufficient vitamin D levels had lower MMP-1 and MMP-13 levels compared to patients with vitamin D insufficiency (p < 0.001 and p < 0.001, respectively).ConclusionFindings from this study showed a strong association between vitamin D deficiency and increased oxidative stress and MMPs activity in patients with knee OA.https://www.frontiersin.org/articles/10.3389/fnut.2023.1101516/fullvitamin Doxidative stressknee osteoarthritisclinicalnutrition |
| spellingShingle | Farshad Amirkhizi Seyed Mojtaba Ghoreishy Emma Baker Soudabeh Hamedi-Shahraki Somayyeh Asghari The association of vitamin D status with oxidative stress biomarkers and matrix metalloproteinases in patients with knee osteoarthritis Frontiers in Nutrition vitamin D oxidative stress knee osteoarthritis clinical nutrition |
| title | The association of vitamin D status with oxidative stress biomarkers and matrix metalloproteinases in patients with knee osteoarthritis |
| title_full | The association of vitamin D status with oxidative stress biomarkers and matrix metalloproteinases in patients with knee osteoarthritis |
| title_fullStr | The association of vitamin D status with oxidative stress biomarkers and matrix metalloproteinases in patients with knee osteoarthritis |
| title_full_unstemmed | The association of vitamin D status with oxidative stress biomarkers and matrix metalloproteinases in patients with knee osteoarthritis |
| title_short | The association of vitamin D status with oxidative stress biomarkers and matrix metalloproteinases in patients with knee osteoarthritis |
| title_sort | association of vitamin d status with oxidative stress biomarkers and matrix metalloproteinases in patients with knee osteoarthritis |
| topic | vitamin D oxidative stress knee osteoarthritis clinical nutrition |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1101516/full |
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