Heterogeneity and function of cancer-associated fibroblasts in renal cell carcinoma
With the advancement of anticancer therapy, there is increasing interest in understanding the tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs) play a pivotal role in the TME and have been the focus of much research in recent years. CAFs play an active role in cancer progression thr...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Journal of the National Cancer Center |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S266700542300025X |
| _version_ | 1797798561131266048 |
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| author | Haijia Tang Wenhao Xu Jiahe Lu Aihetaimujiang Anwaier Dingwei Ye Hailiang Zhang |
| author_facet | Haijia Tang Wenhao Xu Jiahe Lu Aihetaimujiang Anwaier Dingwei Ye Hailiang Zhang |
| author_sort | Haijia Tang |
| collection | DOAJ |
| description | With the advancement of anticancer therapy, there is increasing interest in understanding the tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs) play a pivotal role in the TME and have been the focus of much research in recent years. CAFs play an active role in cancer progression through complex interactions with other cells in the TME, releasing regulatory factors, synthesizing and remodeling the extracellular matrix. However, research on the role of CAFs in renal cell carcinoma (RCC) is still in its nascent stages. Here, we describe the origins and subgroups of CAFs, the roles of CAFs in the development and progression of RCC, the impact of CAFs on RCC prognosis, and the potential of CAFs as treatment targets in RCC. By analyzing CAF subsets, biomarkers, and targeted therapies, we present the significance and contribution of CAFs in RCC research. Furthermore, we highlight the distinct contribution of CAFs in advanced RCC through horizontal comparison with other cancers. This paper provides a comprehensive perspective of recent and foundational studies on the role of CAFs in RCC and other types of cancers and new insights for further study of CAFs in RCC. |
| first_indexed | 2024-03-13T04:06:39Z |
| format | Article |
| id | doaj.art-bd37e0bb025a47d09ef4a33af9709f4f |
| institution | Directory Open Access Journal |
| issn | 2667-0054 |
| language | English |
| last_indexed | 2024-03-13T04:06:39Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the National Cancer Center |
| spelling | doaj.art-bd37e0bb025a47d09ef4a33af9709f4f2023-06-21T07:01:14ZengElsevierJournal of the National Cancer Center2667-00542023-06-0132100105Heterogeneity and function of cancer-associated fibroblasts in renal cell carcinomaHaijia Tang0Wenhao Xu1Jiahe Lu2Aihetaimujiang Anwaier3Dingwei Ye4Hailiang Zhang5Department of Urology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China; Shanghai Genitourinary Cancer Institute, Shanghai, China; Nanjing University of Chinese Medicine, Nanjing, ChinaDepartment of Urology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China; Shanghai Genitourinary Cancer Institute, Shanghai, China; Corresponding authors.Department of Urology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China; Shanghai Genitourinary Cancer Institute, Shanghai, China; School of Cellular and Molecular Medicine, University of Bristol, Bristol, United KingdomDepartment of Urology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China; Shanghai Genitourinary Cancer Institute, Shanghai, ChinaDepartment of Urology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China; Shanghai Genitourinary Cancer Institute, Shanghai, China; Corresponding authors.Department of Urology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China; Shanghai Genitourinary Cancer Institute, Shanghai, China; Corresponding authors.With the advancement of anticancer therapy, there is increasing interest in understanding the tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs) play a pivotal role in the TME and have been the focus of much research in recent years. CAFs play an active role in cancer progression through complex interactions with other cells in the TME, releasing regulatory factors, synthesizing and remodeling the extracellular matrix. However, research on the role of CAFs in renal cell carcinoma (RCC) is still in its nascent stages. Here, we describe the origins and subgroups of CAFs, the roles of CAFs in the development and progression of RCC, the impact of CAFs on RCC prognosis, and the potential of CAFs as treatment targets in RCC. By analyzing CAF subsets, biomarkers, and targeted therapies, we present the significance and contribution of CAFs in RCC research. Furthermore, we highlight the distinct contribution of CAFs in advanced RCC through horizontal comparison with other cancers. This paper provides a comprehensive perspective of recent and foundational studies on the role of CAFs in RCC and other types of cancers and new insights for further study of CAFs in RCC.http://www.sciencedirect.com/science/article/pii/S266700542300025XCancer-associated fibroblastsRenal cell carcinomaTumor microenvironmentTumor heterogeneity |
| spellingShingle | Haijia Tang Wenhao Xu Jiahe Lu Aihetaimujiang Anwaier Dingwei Ye Hailiang Zhang Heterogeneity and function of cancer-associated fibroblasts in renal cell carcinoma Journal of the National Cancer Center Cancer-associated fibroblasts Renal cell carcinoma Tumor microenvironment Tumor heterogeneity |
| title | Heterogeneity and function of cancer-associated fibroblasts in renal cell carcinoma |
| title_full | Heterogeneity and function of cancer-associated fibroblasts in renal cell carcinoma |
| title_fullStr | Heterogeneity and function of cancer-associated fibroblasts in renal cell carcinoma |
| title_full_unstemmed | Heterogeneity and function of cancer-associated fibroblasts in renal cell carcinoma |
| title_short | Heterogeneity and function of cancer-associated fibroblasts in renal cell carcinoma |
| title_sort | heterogeneity and function of cancer associated fibroblasts in renal cell carcinoma |
| topic | Cancer-associated fibroblasts Renal cell carcinoma Tumor microenvironment Tumor heterogeneity |
| url | http://www.sciencedirect.com/science/article/pii/S266700542300025X |
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