The Role of the Gut Microbiome in Psychiatric Disorders
The role of the gut microbiome in mental health has been of great interest in the past years, with several breakthroughs happening in the last decade. Its implications in several psychiatric disorders, namely anxiety, depression, autism and schizophrenia, are highlighted. In this review were include...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Microorganisms |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-2607/10/12/2436 |
| _version_ | 1827637700370366464 |
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| author | Ioana-Maria Andrioaie Alexandru Duhaniuc Eduard Vasile Nastase Luminița Smaranda Iancu Cătălina Luncă Felicia Trofin Dana-Teodora Anton-Păduraru Olivia-Simona Dorneanu |
| author_facet | Ioana-Maria Andrioaie Alexandru Duhaniuc Eduard Vasile Nastase Luminița Smaranda Iancu Cătălina Luncă Felicia Trofin Dana-Teodora Anton-Păduraru Olivia-Simona Dorneanu |
| author_sort | Ioana-Maria Andrioaie |
| collection | DOAJ |
| description | The role of the gut microbiome in mental health has been of great interest in the past years, with several breakthroughs happening in the last decade. Its implications in several psychiatric disorders, namely anxiety, depression, autism and schizophrenia, are highlighted. In this review were included relevant studies on rodents, as well as human studies. There seems to be a connection between the gut microbiome and these pathologies, the link being emphasized both in rodents and humans. The results obtained in murine models align with the results acquired from patients; however, fewer studies regarding anxiety were conducted on humans. The process of sequencing and analyzing the microbiome has been conducted in humans for several other pathologies mentioned above. Additionally, the possible beneficial role of probiotics and postbiotics administered as an aid to the psychiatric medication was analyzed. |
| first_indexed | 2024-03-09T16:04:32Z |
| format | Article |
| id | doaj.art-bd387fe72d0f4b189337f8109ce67907 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-09T16:04:32Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-bd387fe72d0f4b189337f8109ce679072023-11-24T16:49:04ZengMDPI AGMicroorganisms2076-26072022-12-011012243610.3390/microorganisms10122436The Role of the Gut Microbiome in Psychiatric DisordersIoana-Maria Andrioaie0Alexandru Duhaniuc1Eduard Vasile Nastase2Luminița Smaranda Iancu3Cătălina Luncă4Felicia Trofin5Dana-Teodora Anton-Păduraru6Olivia-Simona Dorneanu7Microbiology Department, University of Medicine and Pharmacy “Grigore T. Popa”, 700115 Iasi, RomaniaMicrobiology Department, University of Medicine and Pharmacy “Grigore T. Popa”, 700115 Iasi, RomaniaClinical Hospital of Infectious Diseases “Sf. Parascheva”, 700116 Iasi, RomaniaMicrobiology Department, University of Medicine and Pharmacy “Grigore T. Popa”, 700115 Iasi, RomaniaMicrobiology Department, University of Medicine and Pharmacy “Grigore T. Popa”, 700115 Iasi, RomaniaMicrobiology Department, University of Medicine and Pharmacy “Grigore T. Popa”, 700115 Iasi, RomaniaEmergency Clinical Hospital for Children “Sf. Maria”, 700309 Iasi, RomaniaMicrobiology Department, University of Medicine and Pharmacy “Grigore T. Popa”, 700115 Iasi, RomaniaThe role of the gut microbiome in mental health has been of great interest in the past years, with several breakthroughs happening in the last decade. Its implications in several psychiatric disorders, namely anxiety, depression, autism and schizophrenia, are highlighted. In this review were included relevant studies on rodents, as well as human studies. There seems to be a connection between the gut microbiome and these pathologies, the link being emphasized both in rodents and humans. The results obtained in murine models align with the results acquired from patients; however, fewer studies regarding anxiety were conducted on humans. The process of sequencing and analyzing the microbiome has been conducted in humans for several other pathologies mentioned above. Additionally, the possible beneficial role of probiotics and postbiotics administered as an aid to the psychiatric medication was analyzed.https://www.mdpi.com/2076-2607/10/12/2436gut microbiomemicrobiota–gut–brain axispsychiatric disordersdepressionanxietyautism |
| spellingShingle | Ioana-Maria Andrioaie Alexandru Duhaniuc Eduard Vasile Nastase Luminița Smaranda Iancu Cătălina Luncă Felicia Trofin Dana-Teodora Anton-Păduraru Olivia-Simona Dorneanu The Role of the Gut Microbiome in Psychiatric Disorders Microorganisms gut microbiome microbiota–gut–brain axis psychiatric disorders depression anxiety autism |
| title | The Role of the Gut Microbiome in Psychiatric Disorders |
| title_full | The Role of the Gut Microbiome in Psychiatric Disorders |
| title_fullStr | The Role of the Gut Microbiome in Psychiatric Disorders |
| title_full_unstemmed | The Role of the Gut Microbiome in Psychiatric Disorders |
| title_short | The Role of the Gut Microbiome in Psychiatric Disorders |
| title_sort | role of the gut microbiome in psychiatric disorders |
| topic | gut microbiome microbiota–gut–brain axis psychiatric disorders depression anxiety autism |
| url | https://www.mdpi.com/2076-2607/10/12/2436 |
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