Vaccination with immune complexes modulates the elicitation of functional antibodies against HIV-1

Vaccination with immune complexes modulates the elicitation of functional antibodies against HIV-1

IntroductionNeutralizing antibodies (Abs) are one of the immune components required to protect against viral infections. However, developing vaccines capable of eliciting neutralizing Abs effective against a broad array of HIV-1 isolates has been an arduous challenge.ObjectiveThis study sought to te...

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Bibliographic Details
Main Authors: Catarina E. Hioe, Xiaomei Liu, Andrew N. Banin, Daniel W. Heindel, Jéromine Klingler, Priyanka G. Rao, Christina C. Luo, Xunqing Jiang, Shilpi Pandey, Tracy Ordonez, Philip Barnette, Maxim Totrov, Jiang Zhu, Arthur Nádas, Susan Zolla-Pazner, Chitra Upadhyay, Xiaoying Shen, Xiang-Peng Kong, Ann J. Hessell
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Immunology
Subjects:
HIV-1 vaccine
HIV-1 Env
antibody
immune complex (IC)
virus neutralization
ADCP
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1271686/full

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