By integrating single-cell RNA-seq and bulk RNA-seq in sphingolipid metabolism, CACYBP was identified as a potential therapeutic target in lung adenocarcinoma

By integrating single-cell RNA-seq and bulk RNA-seq in sphingolipid metabolism, CACYBP was identified as a potential therapeutic target in lung adenocarcinoma

BackgroundLung adenocarcinoma (LUAD) is a heterogeneous disease with a dismal prognosis for advanced tumors. Immune-associated cells in the microenvironment substantially impact LUAD formation and progression, which has gained increased attention in recent decades. Sphingolipids have a profound impa...

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Bibliographic Details
Main Authors: Pengpeng Zhang, Shengbin Pei, Zeitian Gong, Yanlong Feng, Xiao Zhang, Fang Yang, Wei Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Immunology
Subjects:
lung adenocarcinoma
sphingolipid
CACYBP
tumor immune microenvironment
immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1115272/full

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