Natural biomolecules and derivatives as anticancer immunomodulatory agents
Despite advancements in chemotherapy, the issue of resistance and non-responsiveness to many chemotherapeutic drugs that are currently in clinical use still remains. Recently, cancer immunotherapy has gathered attention as a novel treatment against select cancers. Immunomodulation is also emerging a...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1070367/full |
| _version_ | 1797957481680338944 |
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| author | Stavroula Bernitsa Rotem Dayan Anastasis Stephanou Iva D. Tzvetanova Ioannis S. Patrikios |
| author_facet | Stavroula Bernitsa Rotem Dayan Anastasis Stephanou Iva D. Tzvetanova Ioannis S. Patrikios |
| author_sort | Stavroula Bernitsa |
| collection | DOAJ |
| description | Despite advancements in chemotherapy, the issue of resistance and non-responsiveness to many chemotherapeutic drugs that are currently in clinical use still remains. Recently, cancer immunotherapy has gathered attention as a novel treatment against select cancers. Immunomodulation is also emerging as an effective strategy to improve efficacy. Natural phytochemicals, with known anticancer properties, been reported to mediate their effects by modulating both traditional cancer pathways and immunity. The mechanism of phytochemical mediated-immunomodulatory activity may be attributed to the remodeling of the tumor immunosuppressive microenvironment and the sensitization of the immune system. This allows for improved recognition and targeting of cancer cells by the immune system and synergy with chemotherapeutics. In this review, we will discuss several well-known plant-derived biomolecules and examine their potential as immunomodulators, and therefore, as novel immunotherapies for cancer treatment. |
| first_indexed | 2024-04-11T00:05:47Z |
| format | Article |
| id | doaj.art-bd3d3a886a474a11b978e7e6fc05fb4d |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-11T00:05:47Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-bd3d3a886a474a11b978e7e6fc05fb4d2023-01-09T12:10:30ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-01-011310.3389/fimmu.2022.10703671070367Natural biomolecules and derivatives as anticancer immunomodulatory agentsStavroula BernitsaRotem DayanAnastasis StephanouIva D. TzvetanovaIoannis S. PatrikiosDespite advancements in chemotherapy, the issue of resistance and non-responsiveness to many chemotherapeutic drugs that are currently in clinical use still remains. Recently, cancer immunotherapy has gathered attention as a novel treatment against select cancers. Immunomodulation is also emerging as an effective strategy to improve efficacy. Natural phytochemicals, with known anticancer properties, been reported to mediate their effects by modulating both traditional cancer pathways and immunity. The mechanism of phytochemical mediated-immunomodulatory activity may be attributed to the remodeling of the tumor immunosuppressive microenvironment and the sensitization of the immune system. This allows for improved recognition and targeting of cancer cells by the immune system and synergy with chemotherapeutics. In this review, we will discuss several well-known plant-derived biomolecules and examine their potential as immunomodulators, and therefore, as novel immunotherapies for cancer treatment.https://www.frontiersin.org/articles/10.3389/fimmu.2022.1070367/fullanticancer phytochemicalsartemisinin derivativesberberinetriptolide derivativesgraviolaEGCG |
| spellingShingle | Stavroula Bernitsa Rotem Dayan Anastasis Stephanou Iva D. Tzvetanova Ioannis S. Patrikios Natural biomolecules and derivatives as anticancer immunomodulatory agents Frontiers in Immunology anticancer phytochemicals artemisinin derivatives berberine triptolide derivatives graviola EGCG |
| title | Natural biomolecules and derivatives as anticancer immunomodulatory agents |
| title_full | Natural biomolecules and derivatives as anticancer immunomodulatory agents |
| title_fullStr | Natural biomolecules and derivatives as anticancer immunomodulatory agents |
| title_full_unstemmed | Natural biomolecules and derivatives as anticancer immunomodulatory agents |
| title_short | Natural biomolecules and derivatives as anticancer immunomodulatory agents |
| title_sort | natural biomolecules and derivatives as anticancer immunomodulatory agents |
| topic | anticancer phytochemicals artemisinin derivatives berberine triptolide derivatives graviola EGCG |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1070367/full |
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