The Role of PI3K/AKT/mTOR Signaling in Hepatocellular Carcinoma Metabolism
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths in the world. Metabolic reprogramming is considered a new hallmark of cancer, but it remains unclearly described in HCC. The dysregulation of the PI3K/AKT/mTOR signaling pathway is common in HCC and is, therefore, a...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/3/2652 |
| _version_ | 1797624352752009216 |
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| author | Ling-Yu Tian Daniel J. Smit Manfred Jücker |
| author_facet | Ling-Yu Tian Daniel J. Smit Manfred Jücker |
| author_sort | Ling-Yu Tian |
| collection | DOAJ |
| description | Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths in the world. Metabolic reprogramming is considered a new hallmark of cancer, but it remains unclearly described in HCC. The dysregulation of the PI3K/AKT/mTOR signaling pathway is common in HCC and is, therefore, a topic of further research and the concern of developing a novel target for liver cancer therapy. In this review, we illustrate mechanisms by which this signaling network is accountable for regulating HCC cellular metabolism, including glucose metabolism, lipid metabolism, amino acid metabolism, pyrimidine metabolism, and oxidative metabolism, and summarize the ongoing clinical trials based on the inhibition of the PI3K/AKT/mTOR pathway in HCC. |
| first_indexed | 2024-03-11T09:41:11Z |
| format | Article |
| id | doaj.art-bd3d6008c4734153966840ce7fb057f3 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T09:41:11Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-bd3d6008c4734153966840ce7fb057f32023-11-16T17:00:26ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-01-01243265210.3390/ijms24032652The Role of PI3K/AKT/mTOR Signaling in Hepatocellular Carcinoma MetabolismLing-Yu Tian0Daniel J. Smit1Manfred Jücker2Institute of Biochemistry and Signal Transduction, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, GermanyInstitute of Biochemistry and Signal Transduction, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, GermanyInstitute of Biochemistry and Signal Transduction, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, GermanyHepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths in the world. Metabolic reprogramming is considered a new hallmark of cancer, but it remains unclearly described in HCC. The dysregulation of the PI3K/AKT/mTOR signaling pathway is common in HCC and is, therefore, a topic of further research and the concern of developing a novel target for liver cancer therapy. In this review, we illustrate mechanisms by which this signaling network is accountable for regulating HCC cellular metabolism, including glucose metabolism, lipid metabolism, amino acid metabolism, pyrimidine metabolism, and oxidative metabolism, and summarize the ongoing clinical trials based on the inhibition of the PI3K/AKT/mTOR pathway in HCC.https://www.mdpi.com/1422-0067/24/3/2652cancer therapyHCC treatmentglucose metabolismlipid metabolismamino acid metabolismpyrimidine metabolism |
| spellingShingle | Ling-Yu Tian Daniel J. Smit Manfred Jücker The Role of PI3K/AKT/mTOR Signaling in Hepatocellular Carcinoma Metabolism International Journal of Molecular Sciences cancer therapy HCC treatment glucose metabolism lipid metabolism amino acid metabolism pyrimidine metabolism |
| title | The Role of PI3K/AKT/mTOR Signaling in Hepatocellular Carcinoma Metabolism |
| title_full | The Role of PI3K/AKT/mTOR Signaling in Hepatocellular Carcinoma Metabolism |
| title_fullStr | The Role of PI3K/AKT/mTOR Signaling in Hepatocellular Carcinoma Metabolism |
| title_full_unstemmed | The Role of PI3K/AKT/mTOR Signaling in Hepatocellular Carcinoma Metabolism |
| title_short | The Role of PI3K/AKT/mTOR Signaling in Hepatocellular Carcinoma Metabolism |
| title_sort | role of pi3k akt mtor signaling in hepatocellular carcinoma metabolism |
| topic | cancer therapy HCC treatment glucose metabolism lipid metabolism amino acid metabolism pyrimidine metabolism |
| url | https://www.mdpi.com/1422-0067/24/3/2652 |
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