Coagulation challenges in pregnancy: from thrombophilia involvement and management to the utility of thrombin generation monitoring
Despite numerous studies, there is no general agreement on an ideal biomarker for estimating thrombotic risk in pregnant women. However, it is accepted that the analysis of thrombin generation assesses the coagulation state more accurately compared to the classical tests used to investigate it. Incr...
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| Format: | Article |
| Language: | English |
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IMR Press
2020-12-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
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| Online Access: | https://www.imrpress.com/journal/CEOG/47/6/10.31083/j.ceog.2020.06.5499 |
| _version_ | 1818552908376965120 |
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| author | R. Mihăilă |
| author_facet | R. Mihăilă |
| author_sort | R. Mihăilă |
| collection | DOAJ |
| description | Despite numerous studies, there is no general agreement on an ideal biomarker for estimating thrombotic risk in pregnant women. However, it is accepted that the analysis of thrombin generation assesses the coagulation state more accurately compared to the classical tests used to investigate it. Increasing evidence has found that thrombin generation is correlated with overall plasma hypercoagulability, which is involved in the occurrence of major obstetrical syndromes, including preeclampsia, intrauterine growth restriction or recurrent abortions. It is difficult to investigate the thrombophilic mutations which, once discovered, are not able to quantify the thrombotic risk. The standardization of thrombin generation assay could allow a quantification of the individual thrombotic risk, which has a high variability, and would facilitate multicenter studies to establish the utility of thrombin generation monitoring for the prophylactic anticoagulant treatment in order to reduce pregnancy-related complications. |
| first_indexed | 2024-12-12T09:19:14Z |
| format | Article |
| id | doaj.art-bd3da49a975f4d219d6be4c57bdf172e |
| institution | Directory Open Access Journal |
| issn | 0390-6663 |
| language | English |
| last_indexed | 2024-12-12T09:19:14Z |
| publishDate | 2020-12-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj.art-bd3da49a975f4d219d6be4c57bdf172e2022-12-22T00:29:17ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632020-12-0147681482010.31083/j.ceog.2020.06.5499S0390-6663(20)00113-XCoagulation challenges in pregnancy: from thrombophilia involvement and management to the utility of thrombin generation monitoringR. Mihăilă0Faculty of Medicine, “Lucian Blaga” University of Sibiu and Department of Hematology, CVASIC Laboratory, Emergency County Clinical Hospital Sibiu, RomaniaDespite numerous studies, there is no general agreement on an ideal biomarker for estimating thrombotic risk in pregnant women. However, it is accepted that the analysis of thrombin generation assesses the coagulation state more accurately compared to the classical tests used to investigate it. Increasing evidence has found that thrombin generation is correlated with overall plasma hypercoagulability, which is involved in the occurrence of major obstetrical syndromes, including preeclampsia, intrauterine growth restriction or recurrent abortions. It is difficult to investigate the thrombophilic mutations which, once discovered, are not able to quantify the thrombotic risk. The standardization of thrombin generation assay could allow a quantification of the individual thrombotic risk, which has a high variability, and would facilitate multicenter studies to establish the utility of thrombin generation monitoring for the prophylactic anticoagulant treatment in order to reduce pregnancy-related complications.https://www.imrpress.com/journal/CEOG/47/6/10.31083/j.ceog.2020.06.5499coagulationpregnancypreeclampsiathrombin generationthrombophiliathrombotic risk |
| spellingShingle | R. Mihăilă Coagulation challenges in pregnancy: from thrombophilia involvement and management to the utility of thrombin generation monitoring Clinical and Experimental Obstetrics & Gynecology coagulation pregnancy preeclampsia thrombin generation thrombophilia thrombotic risk |
| title | Coagulation challenges in pregnancy: from thrombophilia involvement and management to the utility of thrombin generation monitoring |
| title_full | Coagulation challenges in pregnancy: from thrombophilia involvement and management to the utility of thrombin generation monitoring |
| title_fullStr | Coagulation challenges in pregnancy: from thrombophilia involvement and management to the utility of thrombin generation monitoring |
| title_full_unstemmed | Coagulation challenges in pregnancy: from thrombophilia involvement and management to the utility of thrombin generation monitoring |
| title_short | Coagulation challenges in pregnancy: from thrombophilia involvement and management to the utility of thrombin generation monitoring |
| title_sort | coagulation challenges in pregnancy from thrombophilia involvement and management to the utility of thrombin generation monitoring |
| topic | coagulation pregnancy preeclampsia thrombin generation thrombophilia thrombotic risk |
| url | https://www.imrpress.com/journal/CEOG/47/6/10.31083/j.ceog.2020.06.5499 |
| work_keys_str_mv | AT rmihaila coagulationchallengesinpregnancyfromthrombophiliainvolvementandmanagementtotheutilityofthrombingenerationmonitoring |