Comparison of clinical characteristics and prognosis between type I and type II endometrial cancer: a single-center retrospective study
Abstract Objectives To explore the differences in clinical characteristics, prognosis, and risk factors between type I and type II endometrial cancer (EC). Materials and methods We retrospectively collected EC patients diagnosed with type I or type II EC from 2009 to 2021 in the First Affiliated Hos...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Springer
2023-11-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-023-00820-1 |
| _version_ | 1797452194050473984 |
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| author | Yuanpei Wang Yi Sun Fangfang Sun Pin Han Rujia Fan Fang Ren |
| author_facet | Yuanpei Wang Yi Sun Fangfang Sun Pin Han Rujia Fan Fang Ren |
| author_sort | Yuanpei Wang |
| collection | DOAJ |
| description | Abstract Objectives To explore the differences in clinical characteristics, prognosis, and risk factors between type I and type II endometrial cancer (EC). Materials and methods We retrospectively collected EC patients diagnosed with type I or type II EC from 2009 to 2021 in the First Affiliated Hospital of Zhengzhou University. Results In total, 606 eligible EC patients (396 type I, and 210 type II) were included. Baseline analyses revealed that type II patients were older, had more advanced clinical stage, were more likely to receive chemoradiotherapy, and had higher incidence of myometrial infiltration, cervix involvement, lymph node metastasis and positive ascites cytology. Type II significantly favored poorer overall survival (OS) (HR = 9.10, 95%CI 4.79–17.28, P < 0.001) and progression-free survival (PFS) (HR = 6.07, 95%CI 2.75–13.37, P < 0.001) compared to type I. For all included EC, univariate and multivariate COX analyses revealed age, myometrial infiltration and pathological type were independent risk factors for OS and PFS. Subgroup analyses identified age, menopause, clinical stage, and lymph node metastasis as independent risk factors for type I regarding OS. While age, myometrial infiltration and chemoradiotherapy were identified as risk and protective factors for type II regrading OS. Age and cervix involvement were identified as independent risk factors for type I regarding PFS. Myometrial infiltration was identified as independent risk factor for type II regarding PFS. Conclusion Type II patients shared different clinical characteristics and worse prognosis compared to type I, and their independent risk and protective factors also varied. |
| first_indexed | 2024-03-09T15:05:16Z |
| format | Article |
| id | doaj.art-bd3e3b35f8764341af354f0dfa9f03d6 |
| institution | Directory Open Access Journal |
| issn | 2730-6011 |
| language | English |
| last_indexed | 2024-03-09T15:05:16Z |
| publishDate | 2023-11-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj.art-bd3e3b35f8764341af354f0dfa9f03d62023-11-26T13:43:22ZengSpringerDiscover Oncology2730-60112023-11-0114111310.1007/s12672-023-00820-1Comparison of clinical characteristics and prognosis between type I and type II endometrial cancer: a single-center retrospective studyYuanpei Wang0Yi Sun1Fangfang Sun2Pin Han3Rujia Fan4Fang Ren5Department of Obstetrics and Gynecology, First Affiliated Hospital of Zhengzhou UniversityDepartment of Obstetrics and Gynecology, First Affiliated Hospital of Zhengzhou UniversityDepartment of Obstetrics and Gynecology, First Affiliated Hospital of Zhengzhou UniversityDepartment of Obstetrics and Gynecology, Luoyang Maternal and Child Health Care HospitalDepartment of Obstetrics and Gynecology, Henan Province People’s Hospital, Zhengzhou UniversityDepartment of Obstetrics and Gynecology, First Affiliated Hospital of Zhengzhou UniversityAbstract Objectives To explore the differences in clinical characteristics, prognosis, and risk factors between type I and type II endometrial cancer (EC). Materials and methods We retrospectively collected EC patients diagnosed with type I or type II EC from 2009 to 2021 in the First Affiliated Hospital of Zhengzhou University. Results In total, 606 eligible EC patients (396 type I, and 210 type II) were included. Baseline analyses revealed that type II patients were older, had more advanced clinical stage, were more likely to receive chemoradiotherapy, and had higher incidence of myometrial infiltration, cervix involvement, lymph node metastasis and positive ascites cytology. Type II significantly favored poorer overall survival (OS) (HR = 9.10, 95%CI 4.79–17.28, P < 0.001) and progression-free survival (PFS) (HR = 6.07, 95%CI 2.75–13.37, P < 0.001) compared to type I. For all included EC, univariate and multivariate COX analyses revealed age, myometrial infiltration and pathological type were independent risk factors for OS and PFS. Subgroup analyses identified age, menopause, clinical stage, and lymph node metastasis as independent risk factors for type I regarding OS. While age, myometrial infiltration and chemoradiotherapy were identified as risk and protective factors for type II regrading OS. Age and cervix involvement were identified as independent risk factors for type I regarding PFS. Myometrial infiltration was identified as independent risk factor for type II regarding PFS. Conclusion Type II patients shared different clinical characteristics and worse prognosis compared to type I, and their independent risk and protective factors also varied.https://doi.org/10.1007/s12672-023-00820-1Endometrial cancerType IType IIClinical characteristicsPrognosis |
| spellingShingle | Yuanpei Wang Yi Sun Fangfang Sun Pin Han Rujia Fan Fang Ren Comparison of clinical characteristics and prognosis between type I and type II endometrial cancer: a single-center retrospective study Discover Oncology Endometrial cancer Type I Type II Clinical characteristics Prognosis |
| title | Comparison of clinical characteristics and prognosis between type I and type II endometrial cancer: a single-center retrospective study |
| title_full | Comparison of clinical characteristics and prognosis between type I and type II endometrial cancer: a single-center retrospective study |
| title_fullStr | Comparison of clinical characteristics and prognosis between type I and type II endometrial cancer: a single-center retrospective study |
| title_full_unstemmed | Comparison of clinical characteristics and prognosis between type I and type II endometrial cancer: a single-center retrospective study |
| title_short | Comparison of clinical characteristics and prognosis between type I and type II endometrial cancer: a single-center retrospective study |
| title_sort | comparison of clinical characteristics and prognosis between type i and type ii endometrial cancer a single center retrospective study |
| topic | Endometrial cancer Type I Type II Clinical characteristics Prognosis |
| url | https://doi.org/10.1007/s12672-023-00820-1 |
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