Hydrogen sulfide, nitric oxide, and neurodegenerative disorders
Abstract Hydrogen Sulfide (H2S) and Nitric Oxide (NO) have become recognized as important gaseous signaling molecules with enormous pharmacological effects, therapeutic value, and central physiological roles. NO is one of the most important regulators of the pathophysiological condition in central n...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-02-01
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| Series: | Translational Neurodegeneration |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s40035-018-0108-x |
| _version_ | 1819171708382216192 |
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| author | Sandesh Panthi Sumeet Manandhar Kripa Gautam |
| author_facet | Sandesh Panthi Sumeet Manandhar Kripa Gautam |
| author_sort | Sandesh Panthi |
| collection | DOAJ |
| description | Abstract Hydrogen Sulfide (H2S) and Nitric Oxide (NO) have become recognized as important gaseous signaling molecules with enormous pharmacological effects, therapeutic value, and central physiological roles. NO is one of the most important regulators of the pathophysiological condition in central nervous system (CNS). It is critical in the various functioning of the brain; however, beyond certain concentration/level, it is toxic. H2S was regarded as toxic gas with the smell like rotten egg. But, it is now regarded as emerging neuroprotectant and neuromodulator. Recently, the use of donors and inhibitors of these signaling molecules have helped us to identify their accurate and precise biological effects. The most abundant neurotransmitter of CNS (glutamate) is the initiator of the reaction that forms NO, and H2S is highly expressed in brain. These molecules are shedding light on the pathogenesis of various neurological disorders. This review is mainly focused on the importance of H2S and NO for normal functioning of CNS. |
| first_indexed | 2024-12-22T19:55:35Z |
| format | Article |
| id | doaj.art-bd3e49d4b28e4af1999a530b0a4f5a2c |
| institution | Directory Open Access Journal |
| issn | 2047-9158 |
| language | English |
| last_indexed | 2024-12-22T19:55:35Z |
| publishDate | 2018-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Translational Neurodegeneration |
| spelling | doaj.art-bd3e49d4b28e4af1999a530b0a4f5a2c2022-12-21T18:14:26ZengBMCTranslational Neurodegeneration2047-91582018-02-01711810.1186/s40035-018-0108-xHydrogen sulfide, nitric oxide, and neurodegenerative disordersSandesh Panthi0Sumeet Manandhar1Kripa Gautam2Otago School of Biomedical Sciences, University of OtagoDepartment of Pharmacy, Chosun UniversityChina Medical UniversityAbstract Hydrogen Sulfide (H2S) and Nitric Oxide (NO) have become recognized as important gaseous signaling molecules with enormous pharmacological effects, therapeutic value, and central physiological roles. NO is one of the most important regulators of the pathophysiological condition in central nervous system (CNS). It is critical in the various functioning of the brain; however, beyond certain concentration/level, it is toxic. H2S was regarded as toxic gas with the smell like rotten egg. But, it is now regarded as emerging neuroprotectant and neuromodulator. Recently, the use of donors and inhibitors of these signaling molecules have helped us to identify their accurate and precise biological effects. The most abundant neurotransmitter of CNS (glutamate) is the initiator of the reaction that forms NO, and H2S is highly expressed in brain. These molecules are shedding light on the pathogenesis of various neurological disorders. This review is mainly focused on the importance of H2S and NO for normal functioning of CNS.http://link.springer.com/article/10.1186/s40035-018-0108-xHydrogen sulfideNitric oxideCentral nervous systemGasotransmittersGaseous signaling moleculesNeurodegeneration |
| spellingShingle | Sandesh Panthi Sumeet Manandhar Kripa Gautam Hydrogen sulfide, nitric oxide, and neurodegenerative disorders Translational Neurodegeneration Hydrogen sulfide Nitric oxide Central nervous system Gasotransmitters Gaseous signaling molecules Neurodegeneration |
| title | Hydrogen sulfide, nitric oxide, and neurodegenerative disorders |
| title_full | Hydrogen sulfide, nitric oxide, and neurodegenerative disorders |
| title_fullStr | Hydrogen sulfide, nitric oxide, and neurodegenerative disorders |
| title_full_unstemmed | Hydrogen sulfide, nitric oxide, and neurodegenerative disorders |
| title_short | Hydrogen sulfide, nitric oxide, and neurodegenerative disorders |
| title_sort | hydrogen sulfide nitric oxide and neurodegenerative disorders |
| topic | Hydrogen sulfide Nitric oxide Central nervous system Gasotransmitters Gaseous signaling molecules Neurodegeneration |
| url | http://link.springer.com/article/10.1186/s40035-018-0108-x |
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