Epidemiology, risk factors, species distribution, and antifungal susceptibility of candidemia among hospitalized patients with COVID-19
Background and Purpose: The pandemic of COVID-19 has caused a worldwide healthcrisis. Candidemia is a potentially lethal condition that has not yet been enough discussed in patients with COVID‐ 19. The current study aimed to investigate the prevalence of candidemia among Iranian COVID‐ 19 patients a...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Mazandaran University of Medical Sciences
2021-12-01
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| Series: | Current Medical Mycology |
| Subjects: | |
| Online Access: | http://cmm.mazums.ac.ir/article_140980_fc50bc1cc883ca488f82e7f22191e5ef.pdf |
| _version_ | 1828083639635673088 |
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| author | Hasti Kamali Sarvestani Shahram Mahmoudi Pegah Afarinesh khaki Saham Ansari Sara Ghaderkhani Davoud Roostaei Roshanak Daie Ghazvini Seyed Jamal Hashemi Zahra Rafat Alireza Abdollahi |
| author_facet | Hasti Kamali Sarvestani Shahram Mahmoudi Pegah Afarinesh khaki Saham Ansari Sara Ghaderkhani Davoud Roostaei Roshanak Daie Ghazvini Seyed Jamal Hashemi Zahra Rafat Alireza Abdollahi |
| author_sort | Hasti Kamali Sarvestani |
| collection | DOAJ |
| description | Background and Purpose: The pandemic of COVID-19 has caused a worldwide healthcrisis. Candidemia is a potentially lethal condition that has not yet been enough discussed in patients with COVID‐ 19. The current study aimed to investigate the prevalence of candidemia among Iranian COVID‐ 19 patients and characterize itscausative agents and the antifungal susceptibility pattern.Materials and Methods: The present cross-sectional survey was carried out fromMarch 2020 to March 2021 at Imam Khomeini Hospital, Tehran, Iran. Bloodspecimens were obtained from patients with confirmed coronavirus infection who alsohad criteria for candidemia and were examined for any Candida species by conventional and molecular techniques. Susceptibility of isolates to amphotericin B,voriconazole, itraconazole, fluconazole, caspofungin, and 5-flucytosine was testedusing the CLSI broth dilution technique.Results: In total, 153 patients with COVID-19 were included and candidemia wasconfirmed in 12 (7.8 %) of them. The majority of patients were ≥ 50 years of age (n=9)and female (n=8). Moreover, 6 out of the 12 patients were diabetic. The presence ofcentral venous catheters, broad-spectrum antibiotic therapy, ICU admission, andmechanical ventilation was observed in all patients. The C. albicans (n=7, 58.3 %) andC. dubliniensis (n=2, 16.7%) were the most common isolated species. Amphotericin Band 5-flucytosine were the most active drugs. Despite antifungal treatment, 4 out of 12patients (33.3 %) died.Conclusion: Due to the high mortality, the early diagnosis and proper treatment ofcandidemia are essential requirements for optimal clinical outcomes in COVID-19 patients. |
| first_indexed | 2024-04-11T04:11:05Z |
| format | Article |
| id | doaj.art-bd3f475301164080851f1aea1f3cd2ad |
| institution | Directory Open Access Journal |
| issn | 2423-3439 2423-3420 |
| language | English |
| last_indexed | 2024-04-11T04:11:05Z |
| publishDate | 2021-12-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Current Medical Mycology |
| spelling | doaj.art-bd3f475301164080851f1aea1f3cd2ad2023-01-01T06:33:11ZengMazandaran University of Medical SciencesCurrent Medical Mycology2423-34392423-34202021-12-0174121810.18502/cmm.7.4.8406140980Epidemiology, risk factors, species distribution, and antifungal susceptibility of candidemia among hospitalized patients with COVID-19Hasti Kamali Sarvestani0Shahram Mahmoudi1Pegah Afarinesh khaki2Saham Ansari3Sara Ghaderkhani4Davoud Roostaei5Roshanak Daie Ghazvini6Seyed Jamal Hashemi7Zahra Rafat8Alireza Abdollahi9Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, IranDepartment of Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences, Tehran, IranDepartment of Molecular Genetics, Faculty of Advanced science and Technology, Islamic Azad University, Tehran, IranDepartment of Medical Parasitology and Mycology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Infectious Diseases, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, IranDepartment. of Pharmacology, School of Medicine, Guilan University of Medical Sciences, Rasht, IranDepartment of Infectious Diseases, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, IranDepartment of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, IranDepartment. of Medical Microbiology, School of Medicine, Guilan University of Medical Sciences, Rasht, IranDepartment of Pathology, Imam Hospital Complex, Tehran University of Medical Sciences Tehran, IranBackground and Purpose: The pandemic of COVID-19 has caused a worldwide healthcrisis. Candidemia is a potentially lethal condition that has not yet been enough discussed in patients with COVID‐ 19. The current study aimed to investigate the prevalence of candidemia among Iranian COVID‐ 19 patients and characterize itscausative agents and the antifungal susceptibility pattern.Materials and Methods: The present cross-sectional survey was carried out fromMarch 2020 to March 2021 at Imam Khomeini Hospital, Tehran, Iran. Bloodspecimens were obtained from patients with confirmed coronavirus infection who alsohad criteria for candidemia and were examined for any Candida species by conventional and molecular techniques. Susceptibility of isolates to amphotericin B,voriconazole, itraconazole, fluconazole, caspofungin, and 5-flucytosine was testedusing the CLSI broth dilution technique.Results: In total, 153 patients with COVID-19 were included and candidemia wasconfirmed in 12 (7.8 %) of them. The majority of patients were ≥ 50 years of age (n=9)and female (n=8). Moreover, 6 out of the 12 patients were diabetic. The presence ofcentral venous catheters, broad-spectrum antibiotic therapy, ICU admission, andmechanical ventilation was observed in all patients. The C. albicans (n=7, 58.3 %) andC. dubliniensis (n=2, 16.7%) were the most common isolated species. Amphotericin Band 5-flucytosine were the most active drugs. Despite antifungal treatment, 4 out of 12patients (33.3 %) died.Conclusion: Due to the high mortality, the early diagnosis and proper treatment ofcandidemia are essential requirements for optimal clinical outcomes in COVID-19 patients.http://cmm.mazums.ac.ir/article_140980_fc50bc1cc883ca488f82e7f22191e5ef.pdfcandidemiac. albicansc. dubliniensiscovid-19iran |
| spellingShingle | Hasti Kamali Sarvestani Shahram Mahmoudi Pegah Afarinesh khaki Saham Ansari Sara Ghaderkhani Davoud Roostaei Roshanak Daie Ghazvini Seyed Jamal Hashemi Zahra Rafat Alireza Abdollahi Epidemiology, risk factors, species distribution, and antifungal susceptibility of candidemia among hospitalized patients with COVID-19 Current Medical Mycology candidemia c. albicans c. dubliniensis covid-19 iran |
| title | Epidemiology, risk factors, species distribution, and antifungal susceptibility of candidemia among hospitalized patients with COVID-19 |
| title_full | Epidemiology, risk factors, species distribution, and antifungal susceptibility of candidemia among hospitalized patients with COVID-19 |
| title_fullStr | Epidemiology, risk factors, species distribution, and antifungal susceptibility of candidemia among hospitalized patients with COVID-19 |
| title_full_unstemmed | Epidemiology, risk factors, species distribution, and antifungal susceptibility of candidemia among hospitalized patients with COVID-19 |
| title_short | Epidemiology, risk factors, species distribution, and antifungal susceptibility of candidemia among hospitalized patients with COVID-19 |
| title_sort | epidemiology risk factors species distribution and antifungal susceptibility of candidemia among hospitalized patients with covid 19 |
| topic | candidemia c. albicans c. dubliniensis covid-19 iran |
| url | http://cmm.mazums.ac.ir/article_140980_fc50bc1cc883ca488f82e7f22191e5ef.pdf |
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