| Summary: | Although alpha asymmetry has been found to correlate with depression, there is some inconsistency across the wider literature, suggesting the influence of other factors. Some of these may be the presence of peripheral inflammation, age, and sex of participants. To test the interaction of these factors in terms of the association between alpha asymmetry and depression in a community sample, in this study, data were collected on resting frontal alpha asymmetry (FAA) under eyes closed and eyes open conditions, serum C-reactive protein (CRP), age, and self-rated depression in a sample of 44 males and 56 females aged from 18 to 75 years (<i>M</i> = 32.5 yr, SD = 14.1 yr). Using regression models, the results indicated a complex set of associations. FAA values across the FP2-FP1 sites predicted depression in the eyes open condition, but not for any other pairing of sites. Increases in CRP concentration predicted increases in depression for women but not for men. CRP predicted FAA across two frontal sites (F8-F7) under the eyes open condition only. As CRP increased, FAA favoured the left hemisphere for that pair of frontal sites, a result found more strongly for males. Age did not influence these associations. By reflecting a complex, multi-factor interaction, these findings may tentatively provide some explanation for the inconsistency in the wider literature for the FAA–depression hypothesis.
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