Validation of Knock-Out Caco-2 TC7 Cells as Models of Enterocytes of Patients with Familial Genetic Hypobetalipoproteinemias

Validation of Knock-Out Caco-2 TC7 Cells as Models of Enterocytes of Patients with Familial Genetic Hypobetalipoproteinemias

Abetalipoproteinemia (FHBL-SD1) and chylomicron retention disease (FHBL-SD3) are rare recessive disorders of lipoprotein metabolism due to mutations in <i>MTTP</i> and <i>SAR1B</i> genes, respectively, which lead to defective chylomicron formation and secretion. This results...

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Bibliographic Details
Main Authors: Claire Bordat, Donato Vairo, Charlotte Cuerq, Charlotte Halimi, Franck Peiretti, Armelle Penhoat, Aurélie Vieille-Marchiset, Teresa Gonzalez, Marie-Caroline Michalski, Marion Nowicki, Noël Peretti, Emmanuelle Reboul
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Nutrients
Subjects:
abetalipoproteinemia
bioavailability
CRISPR/Cas9
chylomicrons
chylomicron retention disease
familial hypobetalipoproteinemia
Online Access:https://www.mdpi.com/2072-6643/15/3/505

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