Interplay between acute phase response and coagulation/fibrinolysis in chronic spontaneous urticaria
Abstract Background Chronic spontaneous urticaria (CSU) is associated with activation of systemic inflammatory response and coagulation/fibrinolysis. Aim To study whether there is a relationship between the acute phase response and coagulation/fibrinolysis in chronic spontaneous urticaria (CSU) pati...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2018-07-01
|
| Series: | Allergy, Asthma & Clinical Immunology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13223-018-0255-8 |
| _version_ | 1819040701907730432 |
|---|---|
| author | R. Grzanka A. Damasiewicz-Bodzek A. Kasperska-Zajac |
| author_facet | R. Grzanka A. Damasiewicz-Bodzek A. Kasperska-Zajac |
| author_sort | R. Grzanka |
| collection | DOAJ |
| description | Abstract Background Chronic spontaneous urticaria (CSU) is associated with activation of systemic inflammatory response and coagulation/fibrinolysis. Aim To study whether there is a relationship between the acute phase response and coagulation/fibrinolysis in chronic spontaneous urticaria (CSU) patients. Methods Serum concentrations of C-reactive protein (CRP) and interleukin 6 (IL-6), key markers of acute phase response and of D-dimer, a marker of fibrin turnover were investigated in 58 CSU patients assessed with the urticaria activity score (UAS) and the controls. Results Serum concentrations of IL-6, CRP, and D-dimer were significantly higher in CSU patients as compared with the controls. We found statistically significant correlations between D-dimers concentrations and the inflammatory markers: CRP and IL-6 as well as UAS. Conclusions Markers of inflammation (IL-6 and CRP) and of fibrinolysis (D-dimer) are related to each other in CSU, suggesting a possible cross-talk between inflammation and coagulation/fibrinolysis. It might be implicated in pathogenesis of the disease and may be associated with higher risks of cardiovascular diseases in CSU patients. |
| first_indexed | 2024-12-21T09:13:17Z |
| format | Article |
| id | doaj.art-bd431a08cdf541e7bf85a0b9f1f1c840 |
| institution | Directory Open Access Journal |
| issn | 1710-1492 |
| language | English |
| last_indexed | 2024-12-21T09:13:17Z |
| publishDate | 2018-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Allergy, Asthma & Clinical Immunology |
| spelling | doaj.art-bd431a08cdf541e7bf85a0b9f1f1c8402022-12-21T19:09:12ZengBMCAllergy, Asthma & Clinical Immunology1710-14922018-07-011411810.1186/s13223-018-0255-8Interplay between acute phase response and coagulation/fibrinolysis in chronic spontaneous urticariaR. Grzanka0A. Damasiewicz-Bodzek1A. Kasperska-Zajac2Department of Internal Diseases, Dermatology and Allergology, SMDZ in Zabrze, Medical University of Silesia in KatowiceDepartment of Chemistry, SMDZ in Zabrze, Medical University of Silesia in KatowiceDepartment of Internal Diseases, Dermatology and Allergology, SMDZ in Zabrze, Medical University of Silesia in KatowiceAbstract Background Chronic spontaneous urticaria (CSU) is associated with activation of systemic inflammatory response and coagulation/fibrinolysis. Aim To study whether there is a relationship between the acute phase response and coagulation/fibrinolysis in chronic spontaneous urticaria (CSU) patients. Methods Serum concentrations of C-reactive protein (CRP) and interleukin 6 (IL-6), key markers of acute phase response and of D-dimer, a marker of fibrin turnover were investigated in 58 CSU patients assessed with the urticaria activity score (UAS) and the controls. Results Serum concentrations of IL-6, CRP, and D-dimer were significantly higher in CSU patients as compared with the controls. We found statistically significant correlations between D-dimers concentrations and the inflammatory markers: CRP and IL-6 as well as UAS. Conclusions Markers of inflammation (IL-6 and CRP) and of fibrinolysis (D-dimer) are related to each other in CSU, suggesting a possible cross-talk between inflammation and coagulation/fibrinolysis. It might be implicated in pathogenesis of the disease and may be associated with higher risks of cardiovascular diseases in CSU patients.http://link.springer.com/article/10.1186/s13223-018-0255-8D-dimerCRPInflammationChronic spontaneous urticariaCoagulation/fibrinolysisAcute phase response |
| spellingShingle | R. Grzanka A. Damasiewicz-Bodzek A. Kasperska-Zajac Interplay between acute phase response and coagulation/fibrinolysis in chronic spontaneous urticaria Allergy, Asthma & Clinical Immunology D-dimer CRP Inflammation Chronic spontaneous urticaria Coagulation/fibrinolysis Acute phase response |
| title | Interplay between acute phase response and coagulation/fibrinolysis in chronic spontaneous urticaria |
| title_full | Interplay between acute phase response and coagulation/fibrinolysis in chronic spontaneous urticaria |
| title_fullStr | Interplay between acute phase response and coagulation/fibrinolysis in chronic spontaneous urticaria |
| title_full_unstemmed | Interplay between acute phase response and coagulation/fibrinolysis in chronic spontaneous urticaria |
| title_short | Interplay between acute phase response and coagulation/fibrinolysis in chronic spontaneous urticaria |
| title_sort | interplay between acute phase response and coagulation fibrinolysis in chronic spontaneous urticaria |
| topic | D-dimer CRP Inflammation Chronic spontaneous urticaria Coagulation/fibrinolysis Acute phase response |
| url | http://link.springer.com/article/10.1186/s13223-018-0255-8 |
| work_keys_str_mv | AT rgrzanka interplaybetweenacutephaseresponseandcoagulationfibrinolysisinchronicspontaneousurticaria AT adamasiewiczbodzek interplaybetweenacutephaseresponseandcoagulationfibrinolysisinchronicspontaneousurticaria AT akasperskazajac interplaybetweenacutephaseresponseandcoagulationfibrinolysisinchronicspontaneousurticaria |