Histopathological Study of Liraglutide on Renal Deterioration Progression Induced by Doxorubicin
Podocyte injury is a major factor in many renal diseases leading to proteinuria that causes the risk of developing kidney deterioration. Glomerulosclerosis and tubulointerstitial fibrosis are the main histopathological feature as consequence of inflammation and apoptosis a result of long pe...
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| Format: | Article |
| Language: | English |
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College of Pharmacy / Mustansiriyah University
2019-12-01
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| Series: | Al-Mustansiriyah Journal of Pharmaceutical Sciences |
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| Online Access: | https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/641 |
| _version_ | 1797223948766674944 |
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| author | Hayder Hussein Luaibi Mustafa Ghazi Alabbassi Israa Burhan Raoof |
| author_facet | Hayder Hussein Luaibi Mustafa Ghazi Alabbassi Israa Burhan Raoof |
| author_sort | Hayder Hussein Luaibi |
| collection | DOAJ |
| description |
Podocyte injury is a major factor in many renal diseases leading to proteinuria that causes the risk of developing kidney deterioration. Glomerulosclerosis and tubulointerstitial fibrosis are the main histopathological feature as consequence of inflammation and apoptosis a result of
long period of tubular protein load. Liraglutide an incretin hormone (GLP-1) analogue has effective as glycemic control in patient with type 2 diabetes. In recent years, liraglutide appear protected mechanism against inflammation and apoptosis for many tissues through GLP-1 receptor (GLP-1R) activation unrelated with glycemic control. 36 animal Wister rats used in this experiment, first group include 12 rats set as control group received just the normal saline, while second group include 24 rats induced podocyte injury by doxorubicin single dose and third group treated either normal saline or liraglutide (200 µg /kg/day I.P) for 28 days. Histopathological study is used to assess the protected effect of liraglutide on podocyte injury induced in male rats through three main histopathological changes (glomerulosclerosis, tubular damage, inflammatory infiltration) by Hematoxylin and eosin staining. In this study treatment group(C) with liraglutide appeared significant decreased (P< 0.05) in glomerulosclerosis, tubulointerstitial, and inflammatory infiltration after 28 day of treatment. In conclusion, liraglutide is effective in reducing inflammation and apoptosis which associate with chronic renal development as well as renoprotection by glycemic control which is indirectly effect.
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| first_indexed | 2024-04-24T13:45:20Z |
| format | Article |
| id | doaj.art-bd47611a748d4a4d9524a78618784f1c |
| institution | Directory Open Access Journal |
| issn | 1815-0993 2959-183X |
| language | English |
| last_indexed | 2024-04-24T13:45:20Z |
| publishDate | 2019-12-01 |
| publisher | College of Pharmacy / Mustansiriyah University |
| record_format | Article |
| series | Al-Mustansiriyah Journal of Pharmaceutical Sciences |
| spelling | doaj.art-bd47611a748d4a4d9524a78618784f1c2024-04-04T06:57:52ZengCollege of Pharmacy / Mustansiriyah UniversityAl-Mustansiriyah Journal of Pharmaceutical Sciences1815-09932959-183X2019-12-0119410.32947/ajps.v19i4.641Histopathological Study of Liraglutide on Renal Deterioration Progression Induced by DoxorubicinHayder Hussein Luaibi0Mustafa Ghazi Alabbassi1Israa Burhan Raoof2Department of Clinical Laboratory Science, College of Pharmacy, Mustansiriyah University / IraqDepartment of Pharmacology and ToxicologyDepartment of Clinical Laboratory Science, College of Pharmacy, Mustansiriyah University / Iraq Podocyte injury is a major factor in many renal diseases leading to proteinuria that causes the risk of developing kidney deterioration. Glomerulosclerosis and tubulointerstitial fibrosis are the main histopathological feature as consequence of inflammation and apoptosis a result of long period of tubular protein load. Liraglutide an incretin hormone (GLP-1) analogue has effective as glycemic control in patient with type 2 diabetes. In recent years, liraglutide appear protected mechanism against inflammation and apoptosis for many tissues through GLP-1 receptor (GLP-1R) activation unrelated with glycemic control. 36 animal Wister rats used in this experiment, first group include 12 rats set as control group received just the normal saline, while second group include 24 rats induced podocyte injury by doxorubicin single dose and third group treated either normal saline or liraglutide (200 µg /kg/day I.P) for 28 days. Histopathological study is used to assess the protected effect of liraglutide on podocyte injury induced in male rats through three main histopathological changes (glomerulosclerosis, tubular damage, inflammatory infiltration) by Hematoxylin and eosin staining. In this study treatment group(C) with liraglutide appeared significant decreased (P< 0.05) in glomerulosclerosis, tubulointerstitial, and inflammatory infiltration after 28 day of treatment. In conclusion, liraglutide is effective in reducing inflammation and apoptosis which associate with chronic renal development as well as renoprotection by glycemic control which is indirectly effect. https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/641Glomerulosclerosis, liraglutide, podocyte injury, tubulointerstitial inflammation |
| spellingShingle | Hayder Hussein Luaibi Mustafa Ghazi Alabbassi Israa Burhan Raoof Histopathological Study of Liraglutide on Renal Deterioration Progression Induced by Doxorubicin Al-Mustansiriyah Journal of Pharmaceutical Sciences Glomerulosclerosis, liraglutide, podocyte injury, tubulointerstitial inflammation |
| title | Histopathological Study of Liraglutide on Renal Deterioration Progression Induced by Doxorubicin |
| title_full | Histopathological Study of Liraglutide on Renal Deterioration Progression Induced by Doxorubicin |
| title_fullStr | Histopathological Study of Liraglutide on Renal Deterioration Progression Induced by Doxorubicin |
| title_full_unstemmed | Histopathological Study of Liraglutide on Renal Deterioration Progression Induced by Doxorubicin |
| title_short | Histopathological Study of Liraglutide on Renal Deterioration Progression Induced by Doxorubicin |
| title_sort | histopathological study of liraglutide on renal deterioration progression induced by doxorubicin |
| topic | Glomerulosclerosis, liraglutide, podocyte injury, tubulointerstitial inflammation |
| url | https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/641 |
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